FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293633566> ?p ?o ?g. }

• W4293633566 endingPage "8258" @default.
• W4293633566 startingPage "8246" @default.
• W4293633566 abstract "The differential expression and association of cytoplasmic β-subunits with pore-forming α-subunits may contribute significantly to the complexity and heterogeneity of voltage-gated K + channels in excitable cells. Here we examined the association and colocalization of two mammalian β-subunits, Kvβ1 and Kvβ2, with the K + channel α-subunits Kv1.1, Kv1.2, Kv1.4, Kv1.6, and Kv2.1 in adult rat brain. Reciprocal coimmunoprecipitation experiments using subunit-specific antibodies indicated that Kvβ1 and Kvβ2 associate with all the Kv1 α-subunits examined, and with each other, but not with Kv2.1. A much larger portion of the total brain pool of Kv1-containing channel complexes was found associated with Kvβ2 than with Kvβ1. Single- and multiple-label immunohistochemical staining indicated that Kvβ1 codistributes extensively with Kv1.1 and Kv1.4 in cortical interneurons, in the hippocampal perforant path and mossy fiber pathways, and in the globus pallidus and substantia nigra. Kvβ2 codistributes extensively with Kv1.1 and Kv1.2 in all brain regions examined and was strikingly colocalized with these α-subunits in the juxtaparanodal region of nodes of Ranvier as well as in the axons and terminals of cerebellar basket cells. Taken together, these data provide a direct demonstration that Kvβ1 and Kvβ2 associate and colocalize with Kv1 α-subunits in native tissues and provide a biochemical and neuroanatomical basis for the differential contribution of Kv1 α- and β-subunits to electrophysiologically diverse neuronal K + currents." @default.
• W4293633566 created "2022-08-30" @default.
• W4293633566 creator A5017138778 @default.
• W4293633566 creator A5025499463 @default.
• W4293633566 creator A5027311743 @default.
• W4293633566 creator A5036622262 @default.
• W4293633566 creator A5047555131 @default.
• W4293633566 creator A5057172471 @default.
• W4293633566 date "1997-11-01" @default.
• W4293633566 modified "2023-10-12" @default.
• W4293633566 title "Association and Colocalization of the Kvβ1 and Kvβ2 β-Subunits with Kv1 α-Subunits in Mammalian Brain K⁺Channel Complexes" @default.
• W4293633566 cites W110124829 @default.
• W4293633566 cites W1542367756 @default.
• W4293633566 cites W1600171386 @default.
• W4293633566 cites W1646051950 @default.
• W4293633566 cites W1885378673 @default.
• W4293633566 cites W1935182457 @default.
• W4293633566 cites W1963652804 @default.
• W4293633566 cites W1965767576 @default.
• W4293633566 cites W1969018539 @default.
• W4293633566 cites W1969442520 @default.
• W4293633566 cites W1979103094 @default.
• W4293633566 cites W1981797636 @default.
• W4293633566 cites W1983102912 @default.
• W4293633566 cites W1987182471 @default.
• W4293633566 cites W1988904009 @default.
• W4293633566 cites W1995130710 @default.
• W4293633566 cites W2009697737 @default.
• W4293633566 cites W2019280851 @default.
• W4293633566 cites W2019426327 @default.
• W4293633566 cites W2027808289 @default.
• W4293633566 cites W2038894306 @default.
• W4293633566 cites W2045140134 @default.
• W4293633566 cites W2053695860 @default.
• W4293633566 cites W2059957319 @default.
• W4293633566 cites W2061268549 @default.
• W4293633566 cites W2062423323 @default.
• W4293633566 cites W2062502476 @default.
• W4293633566 cites W2067091061 @default.
• W4293633566 cites W2068732182 @default.
• W4293633566 cites W2072972683 @default.
• W4293633566 cites W2079859799 @default.
• W4293633566 cites W2083088703 @default.
• W4293633566 cites W2086172025 @default.
• W4293633566 cites W2087219553 @default.
• W4293633566 cites W2092442184 @default.
• W4293633566 cites W2094529776 @default.
• W4293633566 cites W2095520922 @default.
• W4293633566 cites W2132703716 @default.
• W4293633566 cites W2155979828 @default.
• W4293633566 cites W2164227385 @default.
• W4293633566 cites W2504414049 @default.
• W4293633566 cites W334027006 @default.
• W4293633566 cites W4299417065 @default.
• W4293633566 doi "https://doi.org/10.1523/jneurosci.17-21-08246.1997" @default.
• W4293633566 hasPublicationYear "1997" @default.
• W4293633566 type Work @default.
• W4293633566 citedByCount "245" @default.
• W4293633566 countsByYear W42936335662012 @default.
• W4293633566 countsByYear W42936335662013 @default.
• W4293633566 countsByYear W42936335662014 @default.
• W4293633566 countsByYear W42936335662015 @default.
• W4293633566 countsByYear W42936335662016 @default.
• W4293633566 countsByYear W42936335662017 @default.
• W4293633566 countsByYear W42936335662018 @default.
• W4293633566 countsByYear W42936335662019 @default.
• W4293633566 countsByYear W42936335662020 @default.
• W4293633566 countsByYear W42936335662021 @default.
• W4293633566 countsByYear W42936335662022 @default.
• W4293633566 countsByYear W42936335662023 @default.
• W4293633566 crossrefType "journal-article" @default.
• W4293633566 hasAuthorship W4293633566A5017138778 @default.
• W4293633566 hasAuthorship W4293633566A5025499463 @default.
• W4293633566 hasAuthorship W4293633566A5027311743 @default.
• W4293633566 hasAuthorship W4293633566A5036622262 @default.
• W4293633566 hasAuthorship W4293633566A5047555131 @default.
• W4293633566 hasAuthorship W4293633566A5057172471 @default.
• W4293633566 hasBestOaLocation W42936335661 @default.
• W4293633566 hasConcept C104292427 @default.
• W4293633566 hasConcept C104317684 @default.
• W4293633566 hasConcept C12554922 @default.
• W4293633566 hasConcept C148762608 @default.
• W4293633566 hasConcept C169760540 @default.
• W4293633566 hasConcept C185592680 @default.
• W4293633566 hasConcept C40209533 @default.
• W4293633566 hasConcept C55493867 @default.
• W4293633566 hasConcept C71829478 @default.
• W4293633566 hasConcept C86803240 @default.
• W4293633566 hasConcept C95444343 @default.
• W4293633566 hasConceptScore W4293633566C104292427 @default.
• W4293633566 hasConceptScore W4293633566C104317684 @default.
• W4293633566 hasConceptScore W4293633566C12554922 @default.
• W4293633566 hasConceptScore W4293633566C148762608 @default.
• W4293633566 hasConceptScore W4293633566C169760540 @default.
• W4293633566 hasConceptScore W4293633566C185592680 @default.
• W4293633566 hasConceptScore W4293633566C40209533 @default.
• W4293633566 hasConceptScore W4293633566C55493867 @default.
• W4293633566 hasConceptScore W4293633566C71829478 @default.

• next