FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293659613> ?p ?o ?g. }

• W4293659613 endingPage "2676" @default.
• W4293659613 startingPage "2676" @default.
• W4293659613 abstract "Nitric oxide (NO) is the critical regulator of VEGFR2-induced angiogenesis. Neither VEGF-A over-expression nor L-Arginine (NO-precursor) supplementation has been effective in helping patients with Peripheral Artery Disease (PAD) in clinical trials. One incompletely studied reason may be due to the presence of the less characterized anti-angiogenic VEGF-A (VEGF165b) isoform. We have recently shown that VEGF165b inhibits ischemic angiogenesis by blocking VEGFR1, not VEGFR2 activation. Here we wanted to determine whether VEGF165b inhibition using a monoclonal isoform-specific antibody against VEGF165b vs. control, improved perfusion recovery in preclinical PAD models that have impaired VEGFR2-NO signaling, including (1) type-2 diabetic model, (2) endothelial Nitric oxide synthase-knock out mice, and (3) Myoglobin transgenic mice that have impaired NO bioavailability. In all PAD models, VEGF165b inhibition vs. control enhanced perfusion recovery, increased microvascular density in the ischemic limb, and activated VEGFR1-STAT3 signaling. In vitro, VEGF165b inhibition vs. control enhanced a VEGFR1-dependent endothelial survival/proliferation and angiogenic capacity. These data demonstrate that VEGF165b inhibition induces VEGFR1-STAT3 activation, which does not require increased NO to induce therapeutic angiogenesis in PAD. These results may have implications for advancing therapies for patients with PAD where the VEGFR2-eNOS-NO pathway is impaired." @default.
• W4293659613 created "2022-08-31" @default.
• W4293659613 creator A5003638498 @default.
• W4293659613 creator A5022456171 @default.
• W4293659613 creator A5028117094 @default.
• W4293659613 date "2022-08-28" @default.
• W4293659613 modified "2023-10-14" @default.
• W4293659613 title "Targeting Anti-Angiogenic VEGF165b–VEGFR1 Signaling Promotes Nitric Oxide Independent Therapeutic Angiogenesis in Preclinical Peripheral Artery Disease Models" @default.
• W4293659613 cites W1479731182 @default.
• W4293659613 cites W1521886374 @default.
• W4293659613 cites W1524688066 @default.
• W4293659613 cites W1964948935 @default.
• W4293659613 cites W1968719918 @default.
• W4293659613 cites W1973631566 @default.
• W4293659613 cites W1976221241 @default.
• W4293659613 cites W1989551267 @default.
• W4293659613 cites W1995212065 @default.
• W4293659613 cites W1996644167 @default.
• W4293659613 cites W1997254182 @default.
• W4293659613 cites W1997797780 @default.
• W4293659613 cites W2018347789 @default.
• W4293659613 cites W2021237582 @default.
• W4293659613 cites W2025818897 @default.
• W4293659613 cites W2027856668 @default.
• W4293659613 cites W2034073329 @default.
• W4293659613 cites W2037967237 @default.
• W4293659613 cites W2041817351 @default.
• W4293659613 cites W2049734127 @default.
• W4293659613 cites W2063218096 @default.
• W4293659613 cites W2067020920 @default.
• W4293659613 cites W2073337933 @default.
• W4293659613 cites W2077925758 @default.
• W4293659613 cites W2100425244 @default.
• W4293659613 cites W2117525838 @default.
• W4293659613 cites W2120571947 @default.
• W4293659613 cites W2121129782 @default.
• W4293659613 cites W2124216205 @default.
• W4293659613 cites W2126603547 @default.
• W4293659613 cites W2129081519 @default.
• W4293659613 cites W2142116183 @default.
• W4293659613 cites W2145490597 @default.
• W4293659613 cites W2145779577 @default.
• W4293659613 cites W2146729798 @default.
• W4293659613 cites W2153461920 @default.
• W4293659613 cites W2153726078 @default.
• W4293659613 cites W2159918536 @default.
• W4293659613 cites W2164971856 @default.
• W4293659613 cites W2166005447 @default.
• W4293659613 cites W2501502342 @default.
• W4293659613 cites W2554073053 @default.
• W4293659613 cites W2563544597 @default.
• W4293659613 cites W2599007055 @default.
• W4293659613 cites W2614578122 @default.
• W4293659613 cites W2765507064 @default.
• W4293659613 cites W2767338841 @default.
• W4293659613 cites W2793659838 @default.
• W4293659613 cites W2903371348 @default.
• W4293659613 cites W2911673875 @default.
• W4293659613 cites W2972280427 @default.
• W4293659613 cites W3037958843 @default.
• W4293659613 cites W3172446261 @default.
• W4293659613 cites W4239660878 @default.
• W4293659613 cites W4251999364 @default.
• W4293659613 doi "https://doi.org/10.3390/cells11172676" @default.
• W4293659613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36078086" @default.
• W4293659613 hasPublicationYear "2022" @default.
• W4293659613 type Work @default.
• W4293659613 citedByCount "4" @default.
• W4293659613 countsByYear W42936596132023 @default.
• W4293659613 crossrefType "journal-article" @default.
• W4293659613 hasAuthorship W4293659613A5003638498 @default.
• W4293659613 hasAuthorship W4293659613A5022456171 @default.
• W4293659613 hasAuthorship W4293659613A5028117094 @default.
• W4293659613 hasBestOaLocation W42936596131 @default.
• W4293659613 hasConcept C126322002 @default.
• W4293659613 hasConcept C134018914 @default.
• W4293659613 hasConcept C185592680 @default.
• W4293659613 hasConcept C2777408375 @default.
• W4293659613 hasConcept C2777622882 @default.
• W4293659613 hasConcept C2778271429 @default.
• W4293659613 hasConcept C2778326061 @default.
• W4293659613 hasConcept C2778923194 @default.
• W4293659613 hasConcept C2780394083 @default.
• W4293659613 hasConcept C2908688039 @default.
• W4293659613 hasConcept C502942594 @default.
• W4293659613 hasConcept C519581460 @default.
• W4293659613 hasConcept C55493867 @default.
• W4293659613 hasConcept C62478195 @default.
• W4293659613 hasConcept C71924100 @default.
• W4293659613 hasConcept C98274493 @default.
• W4293659613 hasConceptScore W4293659613C126322002 @default.
• W4293659613 hasConceptScore W4293659613C134018914 @default.
• W4293659613 hasConceptScore W4293659613C185592680 @default.
• W4293659613 hasConceptScore W4293659613C2777408375 @default.
• W4293659613 hasConceptScore W4293659613C2777622882 @default.
• W4293659613 hasConceptScore W4293659613C2778271429 @default.
• W4293659613 hasConceptScore W4293659613C2778326061 @default.
• W4293659613 hasConceptScore W4293659613C2778923194 @default.

• next