Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293660930> ?p ?o ?g. }
- W4293660930 endingPage "1158" @default.
- W4293660930 startingPage "1147" @default.
- W4293660930 abstract "Introduction Carbonic anhydrase (CA) arose significant interest as a potential new target for Chagas disease since its discovery in Trypanosoma cruzi in 2013. Benznidazole and Nifurtimox have been used for Chagas disease treatment for 60 years despite all efforts done for obtaining more efficient treatments, acting in the acute and chronic phases of illness, with fewer side effects and resistance induction.Areas covered We discuss the positive and negative aspects of T. cruzi CA (TcCA) studies as a target for developing new drugs. The current research discoveries and the classes of TcCA inhibitors are reviewed. The sulfonamides and their derivatives are the main inhibitor classes, but hydroxamates and the thiols, were investigated too. These compounds inhibited the growth of the evolutive forms of the parasite. A comparative analysis was done with CAs from other Trypanosomatids and protozoans.Expert opinion The search for new targets and drugs is a significant challenge worldwide, and TcCA is a potential candidate for developing new drugs. Several studied inhibitors were active against Trypanosoma cruzi, but their penetration and toxicity problems emerged. New approaches are in progress to obtain inhibitors with desired properties, allowing further steps such as tests using an adequate animal model and subsequent developments for the preclinical testing." @default.
- W4293660930 created "2022-08-31" @default.
- W4293660930 creator A5018378636 @default.
- W4293660930 creator A5046236889 @default.
- W4293660930 creator A5075665675 @default.
- W4293660930 creator A5079612262 @default.
- W4293660930 date "2022-08-29" @default.
- W4293660930 modified "2023-09-27" @default.
- W4293660930 title "Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?" @default.
- W4293660930 cites W1774799325 @default.
- W4293660930 cites W1783811381 @default.
- W4293660930 cites W1797364982 @default.
- W4293660930 cites W1923974573 @default.
- W4293660930 cites W1988812376 @default.
- W4293660930 cites W1995570889 @default.
- W4293660930 cites W2011974303 @default.
- W4293660930 cites W2028274066 @default.
- W4293660930 cites W2035013654 @default.
- W4293660930 cites W2047178318 @default.
- W4293660930 cites W2048127789 @default.
- W4293660930 cites W2058004521 @default.
- W4293660930 cites W2060923909 @default.
- W4293660930 cites W2064216947 @default.
- W4293660930 cites W2067822500 @default.
- W4293660930 cites W2073387023 @default.
- W4293660930 cites W2079991727 @default.
- W4293660930 cites W2085313140 @default.
- W4293660930 cites W2099116299 @default.
- W4293660930 cites W2100474633 @default.
- W4293660930 cites W2186736649 @default.
- W4293660930 cites W2281953264 @default.
- W4293660930 cites W2315506771 @default.
- W4293660930 cites W2406987241 @default.
- W4293660930 cites W2471456962 @default.
- W4293660930 cites W2482680239 @default.
- W4293660930 cites W2540663276 @default.
- W4293660930 cites W2582608315 @default.
- W4293660930 cites W2771348893 @default.
- W4293660930 cites W2794818075 @default.
- W4293660930 cites W2800489265 @default.
- W4293660930 cites W2801725931 @default.
- W4293660930 cites W2881337652 @default.
- W4293660930 cites W2887621482 @default.
- W4293660930 cites W2895329286 @default.
- W4293660930 cites W2902176740 @default.
- W4293660930 cites W2905431774 @default.
- W4293660930 cites W2910128758 @default.
- W4293660930 cites W2912110377 @default.
- W4293660930 cites W2914860519 @default.
- W4293660930 cites W2951789869 @default.
- W4293660930 cites W2954792327 @default.
- W4293660930 cites W2963919351 @default.
- W4293660930 cites W2964560330 @default.
- W4293660930 cites W2970964422 @default.
- W4293660930 cites W2972330637 @default.
- W4293660930 cites W2980436508 @default.
- W4293660930 cites W2982318062 @default.
- W4293660930 cites W2985820939 @default.
- W4293660930 cites W2986778637 @default.
- W4293660930 cites W3011522952 @default.
- W4293660930 cites W3013664667 @default.
- W4293660930 cites W3014500359 @default.
- W4293660930 cites W3015536237 @default.
- W4293660930 cites W3017340976 @default.
- W4293660930 cites W3017933870 @default.
- W4293660930 cites W3021207418 @default.
- W4293660930 cites W3033841507 @default.
- W4293660930 cites W3037550322 @default.
- W4293660930 cites W3044751445 @default.
- W4293660930 cites W3079552435 @default.
- W4293660930 cites W3090601841 @default.
- W4293660930 cites W3091793668 @default.
- W4293660930 cites W3092330715 @default.
- W4293660930 cites W3092632901 @default.
- W4293660930 cites W3092990449 @default.
- W4293660930 cites W3093322442 @default.
- W4293660930 cites W3110066267 @default.
- W4293660930 cites W3133227992 @default.
- W4293660930 cites W3139181776 @default.
- W4293660930 cites W3146191650 @default.
- W4293660930 cites W3152518361 @default.
- W4293660930 cites W3159979301 @default.
- W4293660930 cites W3163437223 @default.
- W4293660930 cites W3181283967 @default.
- W4293660930 cites W3182753038 @default.
- W4293660930 cites W3185123847 @default.
- W4293660930 cites W3205857313 @default.
- W4293660930 cites W4200487745 @default.
- W4293660930 cites W4205134789 @default.
- W4293660930 cites W4205500321 @default.
- W4293660930 cites W4206494142 @default.
- W4293660930 cites W4206545452 @default.
- W4293660930 cites W4206633401 @default.
- W4293660930 cites W4206839018 @default.
- W4293660930 cites W4207085679 @default.
- W4293660930 cites W4210659249 @default.
- W4293660930 cites W4210881432 @default.
- W4293660930 cites W4210970445 @default.