Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293662858> ?p ?o ?g. }
- W4293662858 abstract "Nonalcoholic fatty liver disease (NAFLD), one of the risk factors for hepatitis, cirrhosis, and even hepatic carcinoma, has been a global public health problem. The polyphenol compound theaflavin-3,3'-digallate (TF3), mainly extracted from black tea, has been reported to produce an effect on hypoglycemic and antilipid deposition in vitro. In our study, we further investigated the function and novel mechanisms of TF3 in protecting NAFLD in vivo. By using leptin-deficient obese (ob/ob) mice with NAFLD symptoms, TF3 treatment prevented body weight and waistline gain, reduced lipid accumulation, and alleviated liver function injury, as well as decreased serum lipid levels and TG levels in livers in ob/ob mice, observing no side effects. Furthermore, the transcriptome sequencing of liver tissue showed that TF3 treatment corrected the expression profiles of livers in ob/ob mice compared with that of the model group. It is interesting to note that TF3 might regulate lipid metabolism via the Fads1/PPARδ/Fabp4 axis. In addition, 16S rRNA sequencing demonstrated that TF3 increased the abundance of Prevotellaceae_UCG-001, norank_f_Ruminococcaceae, and GCA-900066575 and significantly decreased that of Parvibacter. Taken together, the effect of TF3 on NAFLD might be related to lipid metabolism regulated by the Fads1/PPARδ/Fabp4 axis and gut microbiota. TF3 might be a promising candidate for NAFLD therapy." @default.
- W4293662858 created "2022-08-31" @default.
- W4293662858 creator A5000725293 @default.
- W4293662858 creator A5003642180 @default.
- W4293662858 creator A5011482849 @default.
- W4293662858 creator A5017246105 @default.
- W4293662858 creator A5025603599 @default.
- W4293662858 creator A5034359213 @default.
- W4293662858 creator A5046423093 @default.
- W4293662858 creator A5052024256 @default.
- W4293662858 creator A5058740290 @default.
- W4293662858 creator A5065938596 @default.
- W4293662858 creator A5072187407 @default.
- W4293662858 creator A5074088403 @default.
- W4293662858 creator A5085500621 @default.
- W4293662858 date "2022-08-29" @default.
- W4293662858 modified "2023-10-17" @default.
- W4293662858 title "Effect of theaflavin-3,3′-digallate on leptin-deficient induced nonalcoholic fatty liver disease might be related to lipid metabolism regulated by the Fads1/PPARδ/Fabp4 axis and gut microbiota" @default.
- W4293662858 cites W1923747726 @default.
- W4293662858 cites W1985850536 @default.
- W4293662858 cites W1994116239 @default.
- W4293662858 cites W2000430374 @default.
- W4293662858 cites W2009170813 @default.
- W4293662858 cites W2037735499 @default.
- W4293662858 cites W2049503512 @default.
- W4293662858 cites W2053187611 @default.
- W4293662858 cites W2062812115 @default.
- W4293662858 cites W2100380559 @default.
- W4293662858 cites W2113799074 @default.
- W4293662858 cites W2127007481 @default.
- W4293662858 cites W2138050321 @default.
- W4293662858 cites W2139593118 @default.
- W4293662858 cites W2147152358 @default.
- W4293662858 cites W2158220133 @default.
- W4293662858 cites W2234490520 @default.
- W4293662858 cites W2515285081 @default.
- W4293662858 cites W2536700216 @default.
- W4293662858 cites W2571212804 @default.
- W4293662858 cites W2734724639 @default.
- W4293662858 cites W2759997926 @default.
- W4293662858 cites W2765236538 @default.
- W4293662858 cites W2768855410 @default.
- W4293662858 cites W2777780841 @default.
- W4293662858 cites W2790460874 @default.
- W4293662858 cites W2912247027 @default.
- W4293662858 cites W2913071400 @default.
- W4293662858 cites W2918231756 @default.
- W4293662858 cites W2921943722 @default.
- W4293662858 cites W2931772474 @default.
- W4293662858 cites W2947277669 @default.
- W4293662858 cites W2959465866 @default.
- W4293662858 cites W2993083975 @default.
- W4293662858 cites W3004722943 @default.
- W4293662858 cites W3006028518 @default.
- W4293662858 cites W3006330966 @default.
- W4293662858 cites W3012976608 @default.
- W4293662858 cites W3015579983 @default.
- W4293662858 cites W3091510430 @default.
- W4293662858 cites W3097081051 @default.
- W4293662858 cites W3114543294 @default.
- W4293662858 cites W3167613151 @default.
- W4293662858 cites W3170527091 @default.
- W4293662858 cites W3179865180 @default.
- W4293662858 cites W3195317669 @default.
- W4293662858 cites W3198849253 @default.
- W4293662858 cites W3206500415 @default.
- W4293662858 cites W3208249635 @default.
- W4293662858 cites W3209802719 @default.
- W4293662858 cites W3210379090 @default.
- W4293662858 cites W4210729495 @default.
- W4293662858 cites W4210737376 @default.
- W4293662858 cites W4241721607 @default.
- W4293662858 cites W4281253696 @default.
- W4293662858 doi "https://doi.org/10.3389/fphar.2022.925264" @default.
- W4293662858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36105184" @default.
- W4293662858 hasPublicationYear "2022" @default.
- W4293662858 type Work @default.
- W4293662858 citedByCount "2" @default.
- W4293662858 countsByYear W42936628582023 @default.
- W4293662858 crossrefType "journal-article" @default.
- W4293662858 hasAuthorship W4293662858A5000725293 @default.
- W4293662858 hasAuthorship W4293662858A5003642180 @default.
- W4293662858 hasAuthorship W4293662858A5011482849 @default.
- W4293662858 hasAuthorship W4293662858A5017246105 @default.
- W4293662858 hasAuthorship W4293662858A5025603599 @default.
- W4293662858 hasAuthorship W4293662858A5034359213 @default.
- W4293662858 hasAuthorship W4293662858A5046423093 @default.
- W4293662858 hasAuthorship W4293662858A5052024256 @default.
- W4293662858 hasAuthorship W4293662858A5058740290 @default.
- W4293662858 hasAuthorship W4293662858A5065938596 @default.
- W4293662858 hasAuthorship W4293662858A5072187407 @default.
- W4293662858 hasAuthorship W4293662858A5074088403 @default.
- W4293662858 hasAuthorship W4293662858A5085500621 @default.
- W4293662858 hasBestOaLocation W42936628581 @default.
- W4293662858 hasConcept C126322002 @default.
- W4293662858 hasConcept C134018914 @default.
- W4293662858 hasConcept C185592680 @default.
- W4293662858 hasConcept C2776954865 @default.
- W4293662858 hasConcept C2778772119 @default.
- W4293662858 hasConcept C2779134260 @default.