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- W4293672008 abstract "Three new chlorinated compounds, including two propenylphenol derivatives, chlorophenol A and B ( 1 and 2 ), and one benzofuran derivative, chlorophenol C ( 3 ), together with 16 known compounds, were isolated from the mangrove endophytic fungus Amorosia sp. SCSIO 41026. 7-Chloro-3,4-dihydro-6,8-dihydroxy-3-methylisocoumarine ( 4 ) and 2,4-dichloro-3-hydroxy-5-methoxy-toluene ( 5 ) were obtained as new natural products. Their structures were elucidated by physicochemical properties and extensive spectroscopic analysis. Compounds 1 , 4 , 7 , 9 , 13 , 15 , 16 , and 19 possessed inhibitory effects against the excessive production of nitric oxide (NO) and pro-inflammatory cytokines in lipopolysaccharide (LPS)-challenged RAW264.7 macrophages without obvious cytotoxicity. Moreover, 5-chloro-6-hydroxymellein ( 13 ) further alleviated the pathological lung injury of LPS-administrated mice and protected RAW264.7 macrophages against LPS-induced inflammation through PI3K/AKT pathway in vivo . Our research laid the foundation for the application of compound 13 as a potential anti-inflammatory candidate." @default.
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- W4293672008 date "2022-08-29" @default.
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- W4293672008 title "Anti-inflammatory compounds from the mangrove endophytic fungus Amorosia sp. SCSIO 41026" @default.
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- W4293672008 doi "https://doi.org/10.3389/fmicb.2022.976399" @default.
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