FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293676879> ?p ?o ?g. }

• W4293676879 endingPage "9760" @default.
• W4293676879 startingPage "9760" @default.
• W4293676879 abstract "The combination of cross-linked hyaluronate (cHA) and corticosteroid showed more rapid pain or functional improvement in knee osteoarthritis and adhesive capsulitis. However, rare evidence of this combination in treating tendinopathy has been reported. We hypothesized that the specific formulations of cHA and dexamethasone (DEX) conferred amelioration of tendinopathy via anti-apoptosis and anti-senescence. In this controlled laboratory study, primary tenocytes from the human tendinopathic long head of biceps were treated with three cHA formulations (cHA:linealized HA = 80:20, 50:50, and 20:80) + DEX with or without IL-1β stimulation. Cell viability, inflammatory cytokines, tendon-related proliferation markers, matrix metalloproteinases (MMPs), senescent markers, and apoptosis were examined. The in vivo therapeutic effects of the selected cHA + DEX combinations were evaluated in a collagenase-induced rat patellar tendinopathy model. The expression levels of inflammatory mediators, including IL-1β, IL-6, COX-2, MMP-1, and MMP-3 were significantly reduced in all cHA + DEX-treated tenocytes (p < 0.05, all). The cHA (50:50) + DEX and cHA (20:80) + DEX combinations protected tenocytes from cytotoxicity, senescence, and apoptosis induced by DEX in either IL-1β stimulation or none. Furthermore, the two combinations significantly improved the rat experimental tendinopathy by reducing ultrasound feature scores and histological scores as well as the levels of apoptosis, senescence, and senescence-associated secretory phenotypes (p < 0.05, all). We identified two specific cHA formulations (cHA (50:50) and cHA (20:80)) + DEX that could ameliorate tendinopathy through anti-senescence and -apoptosis without cytotoxicity. This study provides a possible approach to treating tendinopathy using the combination of two well-known agents." @default.
• W4293676879 created "2022-08-31" @default.
• W4293676879 creator A5013196995 @default.
• W4293676879 creator A5017050331 @default.
• W4293676879 creator A5017094052 @default.
• W4293676879 creator A5024320813 @default.
• W4293676879 creator A5030860372 @default.
• W4293676879 creator A5034931508 @default.
• W4293676879 creator A5042681614 @default.
• W4293676879 creator A5071277800 @default.
• W4293676879 date "2022-08-28" @default.
• W4293676879 modified "2023-10-05" @default.
• W4293676879 title "Cross-Linked Hyaluronate and Corticosteroid Combination Ameliorate the Rat Experimental Tendinopathy through Anti-Senescent and -Apoptotic Effects" @default.
• W4293676879 cites W1921978279 @default.
• W4293676879 cites W1935296231 @default.
• W4293676879 cites W1974816050 @default.
• W4293676879 cites W1981094876 @default.
• W4293676879 cites W1986818994 @default.
• W4293676879 cites W1987931719 @default.
• W4293676879 cites W1990008900 @default.
• W4293676879 cites W1996545962 @default.
• W4293676879 cites W1999575574 @default.
• W4293676879 cites W2029710824 @default.
• W4293676879 cites W2041701211 @default.
• W4293676879 cites W2057254600 @default.
• W4293676879 cites W2084169429 @default.
• W4293676879 cites W2093492944 @default.
• W4293676879 cites W2108273756 @default.
• W4293676879 cites W2110231121 @default.
• W4293676879 cites W2111571032 @default.
• W4293676879 cites W2112026959 @default.
• W4293676879 cites W2119216845 @default.
• W4293676879 cites W2125809337 @default.
• W4293676879 cites W2125855766 @default.
• W4293676879 cites W2126835745 @default.
• W4293676879 cites W2134451088 @default.
• W4293676879 cites W2136936492 @default.
• W4293676879 cites W2142472895 @default.
• W4293676879 cites W2162229546 @default.
• W4293676879 cites W2162700482 @default.
• W4293676879 cites W2163350304 @default.
• W4293676879 cites W2170697272 @default.
• W4293676879 cites W2515696648 @default.
• W4293676879 cites W2574631460 @default.
• W4293676879 cites W2608899726 @default.
• W4293676879 cites W2619088832 @default.
• W4293676879 cites W2619901099 @default.
• W4293676879 cites W2725136454 @default.
• W4293676879 cites W2745798089 @default.
• W4293676879 cites W2884949164 @default.
• W4293676879 cites W2885093393 @default.
• W4293676879 cites W2912186723 @default.
• W4293676879 cites W2986614333 @default.
• W4293676879 cites W3033560689 @default.
• W4293676879 cites W3045653404 @default.
• W4293676879 cites W3120626955 @default.
• W4293676879 cites W3158922010 @default.
• W4293676879 cites W3175554285 @default.
• W4293676879 cites W3199117170 @default.
• W4293676879 cites W411258228 @default.
• W4293676879 cites W4200477841 @default.
• W4293676879 cites W4212828501 @default.
• W4293676879 cites W4226127615 @default.
• W4293676879 cites W4281751005 @default.
• W4293676879 doi "https://doi.org/10.3390/ijms23179760" @default.
• W4293676879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36077161" @default.
• W4293676879 hasPublicationYear "2022" @default.
• W4293676879 type Work @default.
• W4293676879 citedByCount "1" @default.
• W4293676879 countsByYear W42936768792023 @default.
• W4293676879 crossrefType "journal-article" @default.
• W4293676879 hasAuthorship W4293676879A5013196995 @default.
• W4293676879 hasAuthorship W4293676879A5017050331 @default.
• W4293676879 hasAuthorship W4293676879A5017094052 @default.
• W4293676879 hasAuthorship W4293676879A5024320813 @default.
• W4293676879 hasAuthorship W4293676879A5030860372 @default.
• W4293676879 hasAuthorship W4293676879A5034931508 @default.
• W4293676879 hasAuthorship W4293676879A5042681614 @default.
• W4293676879 hasAuthorship W4293676879A5071277800 @default.
• W4293676879 hasBestOaLocation W42936768791 @default.
• W4293676879 hasConcept C109523444 @default.
• W4293676879 hasConcept C126322002 @default.
• W4293676879 hasConcept C134018914 @default.
• W4293676879 hasConcept C142724271 @default.
• W4293676879 hasConcept C164027704 @default.
• W4293676879 hasConcept C185592680 @default.
• W4293676879 hasConcept C190283241 @default.
• W4293676879 hasConcept C204787440 @default.
• W4293676879 hasConcept C2776164576 @default.
• W4293676879 hasConcept C2776914184 @default.
• W4293676879 hasConcept C2778911562 @default.
• W4293676879 hasConcept C2780105995 @default.
• W4293676879 hasConcept C522857546 @default.
• W4293676879 hasConcept C55493867 @default.
• W4293676879 hasConcept C71924100 @default.
• W4293676879 hasConcept C98274493 @default.
• W4293676879 hasConceptScore W4293676879C109523444 @default.
• W4293676879 hasConceptScore W4293676879C126322002 @default.

• next