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• W4293676890 startingPage "4140" @default.
• W4293676890 abstract "In the past few decades, molecular characterization of thyroid cancer has made significant progress and is able to identify thyroid-cancer-related molecular markers that can then be applied clinically for improved decision making. The aim of this review is to provide a general overview about the molecular markers (mutations and alterations) of thyroid cancers, present several molecular tests, and discuss the clinical applications of identifying these markers supported by the clinical experience of several high-volume thyroid cancer specialists at the McGill university hospitals in Montreal, Canada. Our group experience showed that molecular testing can reclassify more than half of the patients with indeterminate thyroid nodules (Bethesda III and IV) into benign and spare these patients from unnecessary diagnostic surgery. Furthermore, it can help optimize the initial management in thyroid cancers with no evidence of high risk of recurrence of disease preoperatively. While routine molecular testing is not firmly established for thyroid FNA specimens that are suspicious or positive for malignancy (Bethesda V and VI), knowledge of a thyroid nodule's molecular risk group profile in such cases, together with its clinical and radiologic features, can help select the optimal surgical options (lobectomy versus upfront total thyroidectomy and central neck dissection), as demonstrated by our studies." @default.
• W4293676890 created "2022-08-31" @default.
• W4293676890 creator A5010329835 @default.
• W4293676890 creator A5020025409 @default.
• W4293676890 creator A5038199525 @default.
• W4293676890 creator A5047948502 @default.
• W4293676890 date "2022-08-26" @default.
• W4293676890 modified "2023-10-06" @default.
• W4293676890 title "Molecular Testing for Thyroid Nodules: The Experience at McGill University Teaching Hospitals in Canada" @default.
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