FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293676945> ?p ?o ?g. }

• W4293676945 abstract "Tumor acidity is one of the cancer hallmarks and is associated with metabolic reprogramming and the use of glycolysis, which results in a high intracellular lactic acid concentration. Cancer cells avoid acid stress major by the activation and expression of proton and lactate transporters and exchangers and have an inverted pH gradient (extracellular and intracellular pHs are acid and alkaline, respectively). The shift in the tumor acid-base balance promotes proliferation, apoptosis avoidance, invasiveness, metastatic potential, aggressiveness, immune evasion, and treatment resistance. For example, weak-base chemotherapeutic agents may have a substantially reduced cellular uptake capacity due to ion trapping. Lactic acid negatively affects the functions of activated effector T cells, stimulates regulatory T cells, and promotes them to express programmed cell death receptor 1. On the other hand, the inversion of pH gradient could be a cancer weakness that will allow the development of new promising therapies, such as tumor-targeted pH-sensitive antibodies and pH-responsible nanoparticle conjugates with anticancer drugs. The regulation of tumor pH levels by pharmacological inhibition of pH-responsible proteins (monocarboxylate transporters, H+-ATPase, etc.) and lactate dehydrogenase A is also a promising anticancer strategy. Another idea is the oral or parenteral use of buffer systems, such as sodium bicarbonate, to neutralize tumor acidity. Buffering therapy does not counteract standard treatment methods and can be used in combination to increase effectiveness. However, the mechanisms of the anticancer effect of buffering therapy are still unclear, and more research is needed. We have attempted to summarize the basic knowledge about tumor acidity." @default.
• W4293676945 created "2022-08-31" @default.
• W4293676945 creator A5005593542 @default.
• W4293676945 creator A5025269387 @default.
• W4293676945 creator A5028212152 @default.
• W4293676945 creator A5031362509 @default.
• W4293676945 creator A5034623551 @default.
• W4293676945 creator A5036477674 @default.
• W4293676945 date "2022-08-29" @default.
• W4293676945 modified "2023-10-06" @default.
• W4293676945 title "Tumor acidity: From hallmark of cancer to target of treatment" @default.
• W4293676945 cites W1006554241 @default.
• W4293676945 cites W10911041 @default.
• W4293676945 cites W110073676 @default.
• W4293676945 cites W1572739876 @default.
• W4293676945 cites W1777350112 @default.
• W4293676945 cites W185426278 @default.
• W4293676945 cites W1923704062 @default.
• W4293676945 cites W1969897672 @default.
• W4293676945 cites W1972415785 @default.
• W4293676945 cites W1973286318 @default.
• W4293676945 cites W1975566288 @default.
• W4293676945 cites W1981721404 @default.
• W4293676945 cites W1983016356 @default.
• W4293676945 cites W1987133757 @default.
• W4293676945 cites W1996365670 @default.
• W4293676945 cites W1996830477 @default.
• W4293676945 cites W1999596528 @default.
• W4293676945 cites W2003765315 @default.
• W4293676945 cites W2012276721 @default.
• W4293676945 cites W2014409119 @default.
• W4293676945 cites W2017525816 @default.
• W4293676945 cites W2026575376 @default.
• W4293676945 cites W2035566116 @default.
• W4293676945 cites W2046926103 @default.
• W4293676945 cites W2053069467 @default.
• W4293676945 cites W2054838472 @default.
• W4293676945 cites W2059476598 @default.
• W4293676945 cites W2059935962 @default.
• W4293676945 cites W2060878129 @default.
• W4293676945 cites W2068050569 @default.
• W4293676945 cites W2068651607 @default.
• W4293676945 cites W2072451938 @default.
• W4293676945 cites W2073948759 @default.
• W4293676945 cites W2091513759 @default.
• W4293676945 cites W2097259163 @default.
• W4293676945 cites W2099334532 @default.
• W4293676945 cites W2109690807 @default.
• W4293676945 cites W2131027878 @default.
• W4293676945 cites W2146037312 @default.
• W4293676945 cites W2148812205 @default.
• W4293676945 cites W2149078229 @default.
• W4293676945 cites W2155561695 @default.
• W4293676945 cites W2156687584 @default.
• W4293676945 cites W2165836181 @default.
• W4293676945 cites W2166196148 @default.
• W4293676945 cites W2171613038 @default.
• W4293676945 cites W2184384535 @default.
• W4293676945 cites W2195552103 @default.
• W4293676945 cites W2291579888 @default.
• W4293676945 cites W2324799017 @default.
• W4293676945 cites W2495987610 @default.
• W4293676945 cites W2519020116 @default.
• W4293676945 cites W2531977297 @default.
• W4293676945 cites W2557656272 @default.
• W4293676945 cites W2567427945 @default.
• W4293676945 cites W2569990565 @default.
• W4293676945 cites W2582740796 @default.
• W4293676945 cites W2587156779 @default.
• W4293676945 cites W2587438620 @default.
• W4293676945 cites W2592356044 @default.
• W4293676945 cites W2592912788 @default.
• W4293676945 cites W2599172995 @default.
• W4293676945 cites W2607062467 @default.
• W4293676945 cites W2620291133 @default.
• W4293676945 cites W2755677304 @default.
• W4293676945 cites W2760505998 @default.
• W4293676945 cites W2780534461 @default.
• W4293676945 cites W2790858728 @default.
• W4293676945 cites W2796600942 @default.
• W4293676945 cites W2796781998 @default.
• W4293676945 cites W2808592409 @default.
• W4293676945 cites W2883184447 @default.
• W4293676945 cites W2883266145 @default.
• W4293676945 cites W2884046288 @default.
• W4293676945 cites W2892613404 @default.
• W4293676945 cites W2897397780 @default.
• W4293676945 cites W2905085764 @default.
• W4293676945 cites W2906955107 @default.
• W4293676945 cites W2913301044 @default.
• W4293676945 cites W2921283714 @default.
• W4293676945 cites W2923596137 @default.
• W4293676945 cites W2947415066 @default.
• W4293676945 cites W2964104670 @default.
• W4293676945 cites W2964343410 @default.
• W4293676945 cites W2964459657 @default.
• W4293676945 cites W2965696960 @default.
• W4293676945 cites W2969312617 @default.
• W4293676945 cites W2969950932 @default.
• W4293676945 cites W2973298869 @default.

• next