FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293676974> ?p ?o ?g. }

• W4293676974 abstract "Anxiety-like symptoms are common symptoms of methamphetamine (METH) users, especially in the acute withdrawal period, which is an important factor for the high relapse rate during METH acute withdrawal. Exercise has been demonstrated to relieve anxiety-like symptoms during METH withdrawal, but the underlying mechanisms of this anti-anxiety effect are still unclear. Activated microglia and abnormal neuroinflammation play an important role in the pathogenesis of anxiety-like symptoms after METH withdrawal. Moreover, peripheral immune factors were also significantly associated with anxiety symptoms. However, the effects of treadmill exercise on microglial function and neuroinflammation in the striatum and hippocampus during acute METH withdrawal have not been reported. In the current study, we found severe peripheral immune dysfunction in METH users during acute withdrawal, which may in part contribute to anxiety symptoms during METH acute withdrawal. We also showed that 2 weeks of METH exposure induced anxiety-like symptoms in the acute withdrawal period. Additionally, METH exposure resulted in increased microglial activation and proinflammatory cytokines released in the mouse striatum and hippocampus during acute withdrawal. We next evaluated the effects of treadmill exercise in countering anxiety-like symptoms induced by METH acute withdrawal. The results showed that anxiety-like symptoms induced by acute METH withdrawal were attenuated by coadministration of treadmill exercise. In addition, treadmill exercise counteracted METH-induced microglial activation in the mouse striatum and various subregions of the hippocampus. Furthermore, treadmill exercise also reversed the increase in proinflammatory cytokines induced by acute METH withdrawal in the mouse striatum, hippocampus and serum. Our findings suggest that the anti-anxiety effect of treadmill exercise may be mediated by reducing microglial activation and regulating central and peripheral inflammatory responses." @default.
• W4293676974 created "2022-08-31" @default.
• W4293676974 creator A5004828094 @default.
• W4293676974 creator A5009279111 @default.
• W4293676974 creator A5014068004 @default.
• W4293676974 creator A5022540352 @default.
• W4293676974 creator A5026542057 @default.
• W4293676974 creator A5027009536 @default.
• W4293676974 creator A5032965493 @default.
• W4293676974 creator A5034177782 @default.
• W4293676974 creator A5044367029 @default.
• W4293676974 creator A5046966257 @default.
• W4293676974 creator A5067153841 @default.
• W4293676974 date "2022-08-29" @default.
• W4293676974 modified "2023-10-16" @default.
• W4293676974 title "Exercise modulates central and peripheral inflammatory responses and ameliorates methamphetamine-induced anxiety-like symptoms in mice" @default.
• W4293676974 cites W1544235619 @default.
• W4293676974 cites W1552025788 @default.
• W4293676974 cites W1879399529 @default.
• W4293676974 cites W1943082353 @default.
• W4293676974 cites W1990752558 @default.
• W4293676974 cites W1997396304 @default.
• W4293676974 cites W2007383758 @default.
• W4293676974 cites W2022547601 @default.
• W4293676974 cites W2025500109 @default.
• W4293676974 cites W2028869668 @default.
• W4293676974 cites W2038071695 @default.
• W4293676974 cites W2044115042 @default.
• W4293676974 cites W2051359369 @default.
• W4293676974 cites W2056425055 @default.
• W4293676974 cites W2072839634 @default.
• W4293676974 cites W2087374400 @default.
• W4293676974 cites W2090470620 @default.
• W4293676974 cites W2098139332 @default.
• W4293676974 cites W2108050717 @default.
• W4293676974 cites W2131651350 @default.
• W4293676974 cites W2143578877 @default.
• W4293676974 cites W2144023489 @default.
• W4293676974 cites W2152958471 @default.
• W4293676974 cites W2160588949 @default.
• W4293676974 cites W2225546673 @default.
• W4293676974 cites W2270599390 @default.
• W4293676974 cites W2281194714 @default.
• W4293676974 cites W2314634699 @default.
• W4293676974 cites W2324899490 @default.
• W4293676974 cites W2336534940 @default.
• W4293676974 cites W2340376303 @default.
• W4293676974 cites W2517777642 @default.
• W4293676974 cites W2585086069 @default.
• W4293676974 cites W2595385282 @default.
• W4293676974 cites W2595992673 @default.
• W4293676974 cites W2607062688 @default.
• W4293676974 cites W2611744536 @default.
• W4293676974 cites W2746944596 @default.
• W4293676974 cites W2753874878 @default.
• W4293676974 cites W2754689594 @default.
• W4293676974 cites W2769885030 @default.
• W4293676974 cites W2770913451 @default.
• W4293676974 cites W2771531160 @default.
• W4293676974 cites W2771852048 @default.
• W4293676974 cites W2778916101 @default.
• W4293676974 cites W2787368117 @default.
• W4293676974 cites W2793809687 @default.
• W4293676974 cites W2794281609 @default.
• W4293676974 cites W2806300791 @default.
• W4293676974 cites W2891889239 @default.
• W4293676974 cites W2899031631 @default.
• W4293676974 cites W2899596906 @default.
• W4293676974 cites W2903597015 @default.
• W4293676974 cites W2905379358 @default.
• W4293676974 cites W2909562247 @default.
• W4293676974 cites W2917730612 @default.
• W4293676974 cites W2921809577 @default.
• W4293676974 cites W2924301109 @default.
• W4293676974 cites W2936191024 @default.
• W4293676974 cites W2950484331 @default.
• W4293676974 cites W2959690091 @default.
• W4293676974 cites W2964988784 @default.
• W4293676974 cites W2970005463 @default.
• W4293676974 cites W2974028180 @default.
• W4293676974 cites W2981417447 @default.
• W4293676974 cites W2984358033 @default.
• W4293676974 cites W2984667098 @default.
• W4293676974 cites W2991459881 @default.
• W4293676974 cites W2994335873 @default.
• W4293676974 cites W2995842198 @default.
• W4293676974 cites W2997197327 @default.
• W4293676974 cites W2998258463 @default.
• W4293676974 cites W3003860245 @default.
• W4293676974 cites W3006072217 @default.
• W4293676974 cites W3010013465 @default.
• W4293676974 cites W3016206154 @default.
• W4293676974 cites W3016878624 @default.
• W4293676974 cites W3018951806 @default.
• W4293676974 cites W3036134455 @default.
• W4293676974 cites W3040179572 @default.
• W4293676974 cites W3045766713 @default.
• W4293676974 cites W3080862190 @default.
• W4293676974 cites W3087168745 @default.
• W4293676974 cites W3096345730 @default.

• next