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- W4293677056 abstract "The selective macroautophagy/autophagy pathway is an important pathway of protein degradation, regulating signal transduction pathways via selective degradation of certain signaling complexes. TBK1 functions as a key protein in innate immunity or metabolic-associated fatty liver disease (MAFLD); however, the degradation of TBK1 has not been fully investigated. Recently, we have found that HNF1A functions as a novel cargo receptor to bridge TBK1 and MAP1LC3/LC3, hence promoting the degradation of TBK1 and regulating antiviral innate immunity and MAFLD." @default.
- W4293677056 created "2022-08-31" @default.
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- W4293677056 date "2022-08-11" @default.
- W4293677056 modified "2023-10-14" @default.
- W4293677056 title "HNF1A regulates the crosstalk between innate immune responses and MAFLD by mediating autophagic degradation of TBK1" @default.
- W4293677056 cites W4281762271 @default.
- W4293677056 doi "https://doi.org/10.1080/15548627.2022.2110728" @default.
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