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• W4293677319 abstract "Abstract Background Antibodies against myelin-oligodendrocyte-glycoprotein (MOG-Abs) associated disease (MOGAD) has been recognized as a disease entity. Optic neuritis (ON) is the most common symptom in MOGAD. To demonstrate the differences in retinal microvascular characteristics between patients with MOGAD-ON and aquaporin-4 antibody (AQP4-Ab) positive ON. Methods In a prospective study, optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) were used to measure retinal and microvascular parameters. Results Twenty-six MOGAD-ON eyes, 40 AQP4-ON eyes, and 60 control eyes were included in the study. The thickness of RNFL and GCC in MOGAD-ON eyes was significantly lower than that of HC ( p < 0.001, respectively), but comparable to AQP4-ON eyes. The vessel density in retina capillary plexus (RCP) was reduced significantly in MOGAD-ON than that in AQP4-ON ( p < 0.05, respectively). The visual accuracy was positively correlated with vessel density of superficial RCP in MOG-ON ( p = 0.001) and positively correlated with the thickness of the inner retina layer in AQP4-ON ( p < 0.001). Conclusion The retinal neuro-axonal damages between MOGAD-ON and AQP4-ON were comparable. Unlike AQP4-ON eyes, microvascular densities were significantly reduced in MOGAD-ON and were positively correlated with the deterioration of visual acuity in MOGAD-ON. Trial registration Clinical and Imaging Patterns of Neuroinflammation Diseases in China (CLUE, NCT: 04106830)." @default.
• W4293677319 created "2022-08-31" @default.
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• W4293677319 date "2022-08-27" @default.
• W4293677319 modified "2023-10-08" @default.
• W4293677319 title "The difference of the retinal structural and microvascular characteristics in patients with MOGAD-ON and AQP4-ON" @default.
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• W4293677319 doi "https://doi.org/10.1186/s12883-022-02848-2" @default.
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