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- W4293677743 abstract "Monkeypox is an emerging epidemic of concern. The disease is caused by the monkeypox virus and an increasing global incidence with a 2022 outbreak that has spread to Europe amid the COVID-19 pandemic. The new outbreak is associated with novel, previously undiscovered mutations and variants. Currently, the US Food and Drug Administration (FDA) approved poxvirus treatment involves the use of tecovirimat. However, there is otherwise limited pharmacopoeia and research interest in monkeypox. In this study, virtual screening and molecular dynamics were employed to explore the potential repurposing of multiple drugs previously approved by the FDA or other jurisdictions for other applications. Several drugs are predicted to tightly bind to viral proteins, which are crucial in viral replication, including molecules which show high potential for binding the monkeypox D13L capsid protein, whose inhibition has previously been demonstrated to suppress viral replication." @default.
- W4293677743 created "2022-08-31" @default.
- W4293677743 creator A5002912588 @default.
- W4293677743 creator A5071286986 @default.
- W4293677743 creator A5091696446 @default.
- W4293677743 date "2022-08-18" @default.
- W4293677743 modified "2023-10-15" @default.
- W4293677743 title "In Silico Repurposed Drugs against Monkeypox Virus" @default.
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- W4293677743 doi "https://doi.org/10.3390/molecules27165277" @default.
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