Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293685854> ?p ?o ?g. }
- W4293685854 endingPage "1723" @default.
- W4293685854 startingPage "1723" @default.
- W4293685854 abstract "The present study explored chemical constituents of Scutellaria edelbergii essential oils (SEEO) for the first time, extracted through hydro-distillation, and screened them against the microbes and free radicals scavenging effect, pain-relieving, and anti-inflammatory potential employing standard techniques. The SEEO ingredients were noticed via Gas Chromatography-Mass-Spectrometry (GC-MS) analysis and presented fifty-two bioactive compounds contributed (89.52%) with dominant volatile constituent; 3-oxomanoyl oxide (10.09%), 24-norursa-3,12-diene (8.05%), and methyl 7-abieten-18-oate (7.02%). The MTT assay via 96 well-plate and agar-well diffusion techniques against various microbes was determined for minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), IC50, and zone of inhibitions (ZOIs). The SEEO indicated considerable antimicrobial significance against tested bacterial strains viz. Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterococcus faecalis and the fungal strains Fusarium oxysporum and Candida albicans. The free radicals scavenging potential was noticed to be significant in 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) as compared to 2,2'-azino-bis-3-ethylbenzotiazolin-6-sulfonic acid (ABTS) assays with IC50 = 125.0 ± 0.19 µg/mL and IC50 = 153.0 ± 0.31 µg/mL correspondingly; similarly, the antioxidant standard in the DPPH assay was found efficient as compared to ABTS assay. The SEEO also offered an appreciable analgesic significance and presented 54.71% in comparison with standard aspirin, 64.49% reduction in writhes, and an anti-inflammatory potential of 64.13%, as compared to the standard diclofenac sodium inhibition of 71.72%. The SEEO contain bioactive volatile ingredients with antimicrobial, free radical scavenging, pain, and inflammation relieving potentials. Computational analysis validated the anti-inflammatory potential of selected hit methyl 7-abieten-18-oate as a COX-2 enzyme inhibitor. Docking results were very good in terms of docked score (-7.8704 kcal/mol) and binding interactions with the functional residues; furthermore, MD simulation for 100 ns has presented a correlation with docking results with minor fluctuations. In silico, ADMET characteristics supported that methyl 7-abieten-18-oate could be recommended for further investigations in clinical tests and could prove its medicinal status as an anti-inflammatory drug." @default.
- W4293685854 created "2022-08-31" @default.
- W4293685854 creator A5011481214 @default.
- W4293685854 creator A5017302276 @default.
- W4293685854 creator A5020068379 @default.
- W4293685854 creator A5032828510 @default.
- W4293685854 creator A5058658437 @default.
- W4293685854 creator A5066533709 @default.
- W4293685854 creator A5068102297 @default.
- W4293685854 creator A5077327143 @default.
- W4293685854 creator A5085725299 @default.
- W4293685854 date "2022-08-30" @default.
- W4293685854 modified "2023-10-14" @default.
- W4293685854 title "Bridging the Chemical Profile and Biomedical Effects of Scutellaria edelbergii Essential Oils" @default.
- W4293685854 cites W118179289 @default.
- W4293685854 cites W1971849220 @default.
- W4293685854 cites W1977121713 @default.
- W4293685854 cites W1981737096 @default.
- W4293685854 cites W1999278457 @default.
- W4293685854 cites W2001360738 @default.
- W4293685854 cites W2010714231 @default.
- W4293685854 cites W2020862594 @default.
- W4293685854 cites W2029667189 @default.
- W4293685854 cites W2035433275 @default.
- W4293685854 cites W2045324044 @default.
- W4293685854 cites W2049874595 @default.
- W4293685854 cites W2055853635 @default.
- W4293685854 cites W2056427031 @default.
- W4293685854 cites W2061597342 @default.
- W4293685854 cites W2067462243 @default.
- W4293685854 cites W2067643341 @default.
- W4293685854 cites W2068524720 @default.
- W4293685854 cites W2069789444 @default.
- W4293685854 cites W2070819609 @default.
- W4293685854 cites W2071436828 @default.
- W4293685854 cites W2072259978 @default.
- W4293685854 cites W2078588075 @default.
- W4293685854 cites W2085179505 @default.
- W4293685854 cites W2085663480 @default.
- W4293685854 cites W2086203950 @default.
- W4293685854 cites W2092061024 @default.
- W4293685854 cites W2100561975 @default.
- W4293685854 cites W2103034037 @default.
- W4293685854 cites W2105467245 @default.
- W4293685854 cites W2105649494 @default.
- W4293685854 cites W2125038303 @default.
- W4293685854 cites W2126891371 @default.
- W4293685854 cites W2130541969 @default.
- W4293685854 cites W2148436780 @default.
- W4293685854 cites W2163049795 @default.
- W4293685854 cites W2214680641 @default.
- W4293685854 cites W2222008697 @default.
- W4293685854 cites W2249943228 @default.
- W4293685854 cites W2332712348 @default.
- W4293685854 cites W2334738845 @default.
- W4293685854 cites W2346500153 @default.
- W4293685854 cites W2375821550 @default.
- W4293685854 cites W2402440074 @default.
- W4293685854 cites W2413385786 @default.
- W4293685854 cites W2439052303 @default.
- W4293685854 cites W2495586743 @default.
- W4293685854 cites W2509687399 @default.
- W4293685854 cites W2513674150 @default.
- W4293685854 cites W2521444171 @default.
- W4293685854 cites W2587777980 @default.
- W4293685854 cites W2597205870 @default.
- W4293685854 cites W2604160326 @default.
- W4293685854 cites W2772840077 @default.
- W4293685854 cites W2789365548 @default.
- W4293685854 cites W2801121249 @default.
- W4293685854 cites W2802635816 @default.
- W4293685854 cites W2804365393 @default.
- W4293685854 cites W2808828563 @default.
- W4293685854 cites W2830971043 @default.
- W4293685854 cites W2890372942 @default.
- W4293685854 cites W2900006635 @default.
- W4293685854 cites W2910544253 @default.
- W4293685854 cites W2913932956 @default.
- W4293685854 cites W2917236973 @default.
- W4293685854 cites W2917777672 @default.
- W4293685854 cites W2918326742 @default.
- W4293685854 cites W2922051353 @default.
- W4293685854 cites W2929580203 @default.
- W4293685854 cites W2931820060 @default.
- W4293685854 cites W2931877963 @default.
- W4293685854 cites W2946982669 @default.
- W4293685854 cites W2948002831 @default.
- W4293685854 cites W2952293379 @default.
- W4293685854 cites W2965191897 @default.
- W4293685854 cites W2995234410 @default.
- W4293685854 cites W2996384999 @default.
- W4293685854 cites W3002746393 @default.
- W4293685854 cites W3002850055 @default.
- W4293685854 cites W3035260101 @default.
- W4293685854 cites W3047497797 @default.
- W4293685854 cites W3069883202 @default.
- W4293685854 cites W3084816337 @default.
- W4293685854 cites W3087004338 @default.