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- W4293703906 abstract "The antidepressant fluoxetine (FLX) has gained increasing attention due to its frequent detection in aquatic environments and negative effects on non-target organisms. However, knowledge on the ecotoxicological effects of FLX and its removal by microalgae is still limited. In this study, the ecotoxicological effects of FLX (10 −1000 μg/L) were assessed using batch cultures of the freshwater microalgae Chlorella pyrenoidosa for 10 days based on changes in growth, antioxidant response, and photosynthetic process. The removal efficiency, removal mechanism, and degradation pathway of FLX by C. pyrenoidosa were also investigated. The results showed that the growth of C. pyrenoidosa was inhibited by FLX with a 4 d EC50 of 0.464 mg/L. Additionally, FLX significantly inhibited photosynthesis and caused oxidative stress on day 4. However, C. pyrenoidosa can produce resistance and acclimatize to FLX, as reflected by the declining growth inhibition rate, recovered photosynthetic efficiency, and disappearance of oxidative stress on day 10. Despite the toxicity of FLX, C. pyrenoidosa showed 41.2%− 100% removal of FLX after 10 days of exposure. Biodegradation was the primary removal mechanism, accounting for 88.2%− 92.8% of the total removal of FLX. A total of five metabolites were found in the degradation processes of FLX, which showed less toxicity than FLX. The main degradation pathways were proposed as demethylation, O-dealkylation, hydroxylation, and N-acylation. Our results not only highlight the potential application of microalgae in FLX purification, but also provide insight into the fate and ecological risk of FLX in aquatic environments." @default.
- W4293703906 created "2022-08-31" @default.
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- W4293703906 date "2022-10-01" @default.
- W4293703906 modified "2023-10-15" @default.
- W4293703906 title "Ecotoxicological effects of the antidepressant fluoxetine and its removal by the typical freshwater microalgae Chlorella pyrenoidosa" @default.
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- W4293703906 doi "https://doi.org/10.1016/j.ecoenv.2022.114045" @default.
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