Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293724043> ?p ?o ?g. }
- W4293724043 endingPage "9788" @default.
- W4293724043 startingPage "9788" @default.
- W4293724043 abstract "Paraprobiotics, inactivated microbial cells, regulate immune system and exhibit antioxidant and anti-inflammatory activities in patients with weakened immunity or the elderly. This study evaluated the anti-tumor effects of heat-killed Bifidobacterium and Lactobacillus on human gastric cancer MKN1 cells in vitro and in vivo in xenograft animal models. First, cytotoxicity and apoptosis in MKN1 cells of 11 different heat-killed Bifidobacterium or Lactobacillus strains were examined using the MTT assay or flow cytometry, respectively. Then, BALB/c nude mice xenograft animal models were implanted with human gastric cancer MKN1 cells and orally administered a selected single or a mixture of heat-killed bacterial strains to investigate their inhibitory effect on tumor growth. In addition, the expression of p-Akt, p53, Bax, Bak, cleaved caspase-9, -3, and PARP in the tumor tissues was analyzed using Western blotting assay or immunohistochemistry staining. The results show that heat-killed B. bifidum MG731 (MG731), L. reuteri MG5346 (MG5346), and L. rhamnosus MG5200 (MG5200) induced relatively greater apoptosis than other strains in MKN1 cells. Oral administration of a single dose or a mixture of MG731, MG5346, or MG5200 significantly delayed tumor growth, and MG731 had the most effective anti-tumor effect in the xenograft model. Protein expression of p-Akt, p53, Bax, cleaved caspase-3 and -9, and PARP in tumors derived from the xenograft model correlated with the results of the immunohistochemistry staining." @default.
- W4293724043 created "2022-08-31" @default.
- W4293724043 creator A5001100010 @default.
- W4293724043 creator A5010214504 @default.
- W4293724043 creator A5055313124 @default.
- W4293724043 creator A5083651391 @default.
- W4293724043 creator A5089053629 @default.
- W4293724043 date "2022-08-29" @default.
- W4293724043 modified "2023-10-16" @default.
- W4293724043 title "Anti-Tumor Effect of Heat-Killed Bifidobacterium bifidum on Human Gastric Cancer through Akt-p53-Dependent Mitochondrial Apoptosis in Xenograft Models" @default.
- W4293724043 cites W117394747 @default.
- W4293724043 cites W1967985127 @default.
- W4293724043 cites W1983210183 @default.
- W4293724043 cites W1984143791 @default.
- W4293724043 cites W1995117660 @default.
- W4293724043 cites W2037545733 @default.
- W4293724043 cites W2037613441 @default.
- W4293724043 cites W2041631543 @default.
- W4293724043 cites W2046914784 @default.
- W4293724043 cites W2060185417 @default.
- W4293724043 cites W2103445534 @default.
- W4293724043 cites W2119304949 @default.
- W4293724043 cites W2134176478 @default.
- W4293724043 cites W2138466194 @default.
- W4293724043 cites W2138784722 @default.
- W4293724043 cites W2171843410 @default.
- W4293724043 cites W2227234059 @default.
- W4293724043 cites W2339460657 @default.
- W4293724043 cites W2491844534 @default.
- W4293724043 cites W2516156628 @default.
- W4293724043 cites W2586778891 @default.
- W4293724043 cites W2612161536 @default.
- W4293724043 cites W2772366909 @default.
- W4293724043 cites W2789303991 @default.
- W4293724043 cites W2790256881 @default.
- W4293724043 cites W2793972506 @default.
- W4293724043 cites W2910775131 @default.
- W4293724043 cites W2946487898 @default.
- W4293724043 cites W2948210547 @default.
- W4293724043 cites W2955577995 @default.
- W4293724043 cites W2971713670 @default.
- W4293724043 cites W2974408176 @default.
- W4293724043 cites W3000057015 @default.
- W4293724043 cites W3013551363 @default.
- W4293724043 cites W3014462210 @default.
- W4293724043 cites W3015420049 @default.
- W4293724043 cites W3024495812 @default.
- W4293724043 cites W3024730957 @default.
- W4293724043 cites W3059301501 @default.
- W4293724043 cites W3083390178 @default.
- W4293724043 cites W3119409060 @default.
- W4293724043 cites W3125007765 @default.
- W4293724043 cites W3133556215 @default.
- W4293724043 cites W3142049344 @default.
- W4293724043 cites W3156655472 @default.
- W4293724043 cites W3159981733 @default.
- W4293724043 cites W4205616186 @default.
- W4293724043 cites W4214572067 @default.
- W4293724043 cites W4224267469 @default.
- W4293724043 cites W4285744646 @default.
- W4293724043 doi "https://doi.org/10.3390/ijms23179788" @default.
- W4293724043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36077182" @default.
- W4293724043 hasPublicationYear "2022" @default.
- W4293724043 type Work @default.
- W4293724043 citedByCount "4" @default.
- W4293724043 countsByYear W42937240432023 @default.
- W4293724043 crossrefType "journal-article" @default.
- W4293724043 hasAuthorship W4293724043A5001100010 @default.
- W4293724043 hasAuthorship W4293724043A5010214504 @default.
- W4293724043 hasAuthorship W4293724043A5055313124 @default.
- W4293724043 hasAuthorship W4293724043A5083651391 @default.
- W4293724043 hasAuthorship W4293724043A5089053629 @default.
- W4293724043 hasBestOaLocation W42937240431 @default.
- W4293724043 hasConcept C100544194 @default.
- W4293724043 hasConcept C121608353 @default.
- W4293724043 hasConcept C153911025 @default.
- W4293724043 hasConcept C185592680 @default.
- W4293724043 hasConcept C190283241 @default.
- W4293724043 hasConcept C203014093 @default.
- W4293724043 hasConcept C204232928 @default.
- W4293724043 hasConcept C2776651480 @default.
- W4293724043 hasConcept C2778641530 @default.
- W4293724043 hasConcept C2780206646 @default.
- W4293724043 hasConcept C2780305828 @default.
- W4293724043 hasConcept C2780783641 @default.
- W4293724043 hasConcept C502942594 @default.
- W4293724043 hasConcept C54355233 @default.
- W4293724043 hasConcept C553184892 @default.
- W4293724043 hasConcept C55493867 @default.
- W4293724043 hasConcept C75217442 @default.
- W4293724043 hasConcept C86803240 @default.
- W4293724043 hasConcept C96232424 @default.
- W4293724043 hasConceptScore W4293724043C100544194 @default.
- W4293724043 hasConceptScore W4293724043C121608353 @default.
- W4293724043 hasConceptScore W4293724043C153911025 @default.
- W4293724043 hasConceptScore W4293724043C185592680 @default.
- W4293724043 hasConceptScore W4293724043C190283241 @default.
- W4293724043 hasConceptScore W4293724043C203014093 @default.