FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293724332> ?p ?o ?g. }

• W4293724332 endingPage "9799" @default.
• W4293724332 startingPage "9799" @default.
• W4293724332 abstract "The type I interferon (IFN) response is one of the primary defense systems against various pathogens. Although rubella virus (RuV) infection is known to cause dysfunction of various organs and systems, including the central nervous system, little is known about how human neural cells evoke protective immunity against RuV infection, leading to controlling RuV replication. Using cultured human neural cells experimentally infected with RuV RA27/3 strain, we characterized the type I IFN immune response against the virus. RuV infected cultured human neural cell lines and induced IFN-β production, leading to the activation of signal transducer and activator of transcription 1 (STAT1) and the increased expression of IFN-stimulated genes (ISGs). Melanoma-differentiation-associated gene 5 (MDA5), one of the cytoplasmic retinoic acid-inducible gene I (RIG-I)-like receptors, is required for the RuV-triggered IFN-β mRNA induction in U373MG cells. We also showed that upregulation of RuV-triggered ISGs was attenuated by blocking IFN-α/β receptor subunit 2 (IFNAR2) using an IFNAR2-specific neutralizing antibody or by repressing mitochondrial antiviral signaling protein (MAVS) expression using MAVS-targeting short hairpin RNA (shRNA). Furthermore, treating RuV-infected cells with BX-795, a TANK-binding kinase 1 (TBK1)/I kappa B kinase ε (IKKε) inhibitor, robustly reduced STAT1 phosphorylation and expression of ISGs, enhancing viral gene expression and infectious virion production. Overall, our findings suggest that the RuV-triggered type I IFN-mediated antiviral response is essential in controlling RuV gene expression and viral replication in human neural cells." @default.
• W4293724332 created "2022-08-31" @default.
• W4293724332 creator A5022172164 @default.
• W4293724332 creator A5034516171 @default.
• W4293724332 creator A5036811980 @default.
• W4293724332 creator A5042879933 @default.
• W4293724332 creator A5060334039 @default.
• W4293724332 date "2022-08-29" @default.
• W4293724332 modified "2023-09-25" @default.
• W4293724332 title "Rubella Virus Triggers Type I Interferon Antiviral Response in Cultured Human Neural Cells: Involvement in the Control of Viral Gene Expression and Infectious Progeny Production" @default.
• W4293724332 cites W1964626485 @default.
• W4293724332 cites W1973646620 @default.
• W4293724332 cites W1974823957 @default.
• W4293724332 cites W1981229471 @default.
• W4293724332 cites W1982570980 @default.
• W4293724332 cites W1987009823 @default.
• W4293724332 cites W1989330640 @default.
• W4293724332 cites W1998624755 @default.
• W4293724332 cites W1999556384 @default.
• W4293724332 cites W2000871561 @default.
• W4293724332 cites W2004731666 @default.
• W4293724332 cites W2009835055 @default.
• W4293724332 cites W2018828712 @default.
• W4293724332 cites W2031913105 @default.
• W4293724332 cites W2035509260 @default.
• W4293724332 cites W2042433863 @default.
• W4293724332 cites W2051636160 @default.
• W4293724332 cites W2052046406 @default.
• W4293724332 cites W2061242286 @default.
• W4293724332 cites W2063310200 @default.
• W4293724332 cites W2067832301 @default.
• W4293724332 cites W2072572256 @default.
• W4293724332 cites W2081633479 @default.
• W4293724332 cites W2084880831 @default.
• W4293724332 cites W2093579074 @default.
• W4293724332 cites W2099533608 @default.
• W4293724332 cites W2101525702 @default.
• W4293724332 cites W2103347705 @default.
• W4293724332 cites W2104517224 @default.
• W4293724332 cites W2107513655 @default.
• W4293724332 cites W2117365211 @default.
• W4293724332 cites W2125566625 @default.
• W4293724332 cites W2127096990 @default.
• W4293724332 cites W2137303998 @default.
• W4293724332 cites W2140815975 @default.
• W4293724332 cites W2141137217 @default.
• W4293724332 cites W2144787399 @default.
• W4293724332 cites W2148214390 @default.
• W4293724332 cites W2157135427 @default.
• W4293724332 cites W2170849896 @default.
• W4293724332 cites W2188304977 @default.
• W4293724332 cites W2283295428 @default.
• W4293724332 cites W2795052338 @default.
• W4293724332 cites W2923545753 @default.
• W4293724332 cites W2936804536 @default.
• W4293724332 cites W2959449984 @default.
• W4293724332 cites W2970587095 @default.
• W4293724332 cites W3092511958 @default.
• W4293724332 cites W3129111142 @default.
• W4293724332 cites W3131756877 @default.
• W4293724332 cites W3145219860 @default.
• W4293724332 cites W3195506304 @default.
• W4293724332 cites W3206747612 @default.
• W4293724332 cites W4211204530 @default.
• W4293724332 cites W4220973428 @default.
• W4293724332 doi "https://doi.org/10.3390/ijms23179799" @default.
• W4293724332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36077193" @default.
• W4293724332 hasPublicationYear "2022" @default.
• W4293724332 type Work @default.
• W4293724332 citedByCount "2" @default.
• W4293724332 countsByYear W42937243322023 @default.
• W4293724332 crossrefType "journal-article" @default.
• W4293724332 hasAuthorship W4293724332A5022172164 @default.
• W4293724332 hasAuthorship W4293724332A5034516171 @default.
• W4293724332 hasAuthorship W4293724332A5036811980 @default.
• W4293724332 hasAuthorship W4293724332A5042879933 @default.
• W4293724332 hasAuthorship W4293724332A5060334039 @default.
• W4293724332 hasBestOaLocation W42937243321 @default.
• W4293724332 hasConcept C111289621 @default.
• W4293724332 hasConcept C136449434 @default.
• W4293724332 hasConcept C140704245 @default.
• W4293724332 hasConcept C159047783 @default.
• W4293724332 hasConcept C173396325 @default.
• W4293724332 hasConcept C190232843 @default.
• W4293724332 hasConcept C203014093 @default.
• W4293724332 hasConcept C2522874641 @default.
• W4293724332 hasConcept C2776178377 @default.
• W4293724332 hasConcept C2776954689 @default.
• W4293724332 hasConcept C2777003663 @default.
• W4293724332 hasConcept C54355233 @default.
• W4293724332 hasConcept C81885089 @default.
• W4293724332 hasConcept C86803240 @default.
• W4293724332 hasConcept C8891405 @default.
• W4293724332 hasConceptScore W4293724332C111289621 @default.
• W4293724332 hasConceptScore W4293724332C136449434 @default.
• W4293724332 hasConceptScore W4293724332C140704245 @default.
• W4293724332 hasConceptScore W4293724332C159047783 @default.
• W4293724332 hasConceptScore W4293724332C173396325 @default.

• next