FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293726411> ?p ?o ?g. }

• W4293726411 endingPage "1870" @default.
• W4293726411 startingPage "1870" @default.
• W4293726411 abstract "Monkeypox disease (MPX) is currently considered a global threat after COVID-19. European Medicines Agency (EMA) approved Tecovirimat in capsule dosage form (200 mg) as the first treatment for MPX in January 2022. This article highlights Tecovirimat's development and patent literature review and is believed to benefit the scientists working on developing MPX treatments. The literature for Tecovirimat was gathered from the website of SIGA Technologies (developer of Tecovirimat), regulatory agencies (EMA, United States Food and Drug Administration (USFDA), and Health Canada), PubMed, and freely accessible clinical/patent databases. Tecovirimat was first recognized as an anti-orthopoxvirus molecule in 2002 and developed by SIGA Technologies. The USFDA and Health Canada have also recently approved Tecovirimat to treat smallpox in 2018 and 2021, respectively. The efficacy of Tecovirimat was verified in infected non-human primates (monkeys) and rabbits under the USFDA's Animal Rule. Most clinical studies have been done on Tecovirimat's safety and pharmacokinetic parameters. The patent literature has revealed inventions related to the capsule, injection, suspension, crystalline forms, amorphous form, and drug combinations (Tecovirimat + cidofovir) and process for preparing Tecovirimat. The authors foresee the off-label use of Tecovirimat in the USA and Canada for MPX and other orthopoxvirus infections. The authors also trust that there is immense scope for developing new Tecovirimat-based treatments (new drug combinations with other antivirals) for orthopoxvirus and other viral diseases. Drug interaction studies and drug resistance studies on Tecovirimat are also recommended. Tecovirimat is believed to handle the current MPX outbreak and is a new hope of biosecurity against smallpox or orthopoxvirus-related bioterrorism attack." @default.
• W4293726411 created "2022-08-31" @default.
• W4293726411 creator A5005355709 @default.
• W4293726411 creator A5014013848 @default.
• W4293726411 creator A5022886964 @default.
• W4293726411 creator A5025988395 @default.
• W4293726411 creator A5033653339 @default.
• W4293726411 creator A5041421375 @default.
• W4293726411 creator A5047650720 @default.
• W4293726411 creator A5050758554 @default.
• W4293726411 creator A5064594316 @default.
• W4293726411 creator A5086120964 @default.
• W4293726411 creator A5086472775 @default.
• W4293726411 creator A5089627009 @default.
• W4293726411 date "2022-08-25" @default.
• W4293726411 modified "2023-10-14" @default.
• W4293726411 title "A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox Outbreak" @default.
• W4293726411 cites W1997782497 @default.
• W4293726411 cites W1998347956 @default.
• W4293726411 cites W2003461004 @default.
• W4293726411 cites W2022657624 @default.
• W4293726411 cites W2089500834 @default.
• W4293726411 cites W2109305863 @default.
• W4293726411 cites W2110922235 @default.
• W4293726411 cites W2114782042 @default.
• W4293726411 cites W2136561168 @default.
• W4293726411 cites W2564477152 @default.
• W4293726411 cites W2809783981 @default.
• W4293726411 cites W2886583550 @default.
• W4293726411 cites W2891488137 @default.
• W4293726411 cites W2898594983 @default.
• W4293726411 cites W2939369815 @default.
• W4293726411 cites W3083508002 @default.
• W4293726411 cites W3133762373 @default.
• W4293726411 cites W3165135430 @default.
• W4293726411 cites W3184507190 @default.
• W4293726411 cites W4214742985 @default.
• W4293726411 cites W4220980279 @default.
• W4293726411 cites W4224949934 @default.
• W4293726411 cites W4225142604 @default.
• W4293726411 cites W4281477179 @default.
• W4293726411 cites W4281675858 @default.
• W4293726411 cites W4281692909 @default.
• W4293726411 cites W4281748058 @default.
• W4293726411 cites W4282827221 @default.
• W4293726411 cites W4282917161 @default.
• W4293726411 doi "https://doi.org/10.3390/v14091870" @default.
• W4293726411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36146675" @default.
• W4293726411 hasPublicationYear "2022" @default.
• W4293726411 type Work @default.
• W4293726411 citedByCount "15" @default.
• W4293726411 countsByYear W42937264112022 @default.
• W4293726411 countsByYear W42937264112023 @default.
• W4293726411 crossrefType "journal-article" @default.
• W4293726411 hasAuthorship W4293726411A5005355709 @default.
• W4293726411 hasAuthorship W4293726411A5014013848 @default.
• W4293726411 hasAuthorship W4293726411A5022886964 @default.
• W4293726411 hasAuthorship W4293726411A5025988395 @default.
• W4293726411 hasAuthorship W4293726411A5033653339 @default.
• W4293726411 hasAuthorship W4293726411A5041421375 @default.
• W4293726411 hasAuthorship W4293726411A5047650720 @default.
• W4293726411 hasAuthorship W4293726411A5050758554 @default.
• W4293726411 hasAuthorship W4293726411A5064594316 @default.
• W4293726411 hasAuthorship W4293726411A5086120964 @default.
• W4293726411 hasAuthorship W4293726411A5086472775 @default.
• W4293726411 hasAuthorship W4293726411A5089627009 @default.
• W4293726411 hasBestOaLocation W42937264111 @default.
• W4293726411 hasConcept C104317684 @default.
• W4293726411 hasConcept C138816342 @default.
• W4293726411 hasConcept C142724271 @default.
• W4293726411 hasConcept C159047783 @default.
• W4293726411 hasConcept C2778011067 @default.
• W4293726411 hasConcept C2779094796 @default.
• W4293726411 hasConcept C2781356689 @default.
• W4293726411 hasConcept C40767141 @default.
• W4293726411 hasConcept C55493867 @default.
• W4293726411 hasConcept C71924100 @default.
• W4293726411 hasConcept C86803240 @default.
• W4293726411 hasConceptScore W4293726411C104317684 @default.
• W4293726411 hasConceptScore W4293726411C138816342 @default.
• W4293726411 hasConceptScore W4293726411C142724271 @default.
• W4293726411 hasConceptScore W4293726411C159047783 @default.
• W4293726411 hasConceptScore W4293726411C2778011067 @default.
• W4293726411 hasConceptScore W4293726411C2779094796 @default.
• W4293726411 hasConceptScore W4293726411C2781356689 @default.
• W4293726411 hasConceptScore W4293726411C40767141 @default.
• W4293726411 hasConceptScore W4293726411C55493867 @default.
• W4293726411 hasConceptScore W4293726411C71924100 @default.
• W4293726411 hasConceptScore W4293726411C86803240 @default.
• W4293726411 hasIssue "9" @default.
• W4293726411 hasLocation W42937264111 @default.
• W4293726411 hasLocation W42937264112 @default.
• W4293726411 hasLocation W42937264113 @default.
• W4293726411 hasLocation W42937264114 @default.
• W4293726411 hasOpenAccess W4293726411 @default.
• W4293726411 hasPrimaryLocation W42937264111 @default.
• W4293726411 hasRelatedWork W1725441838 @default.
• W4293726411 hasRelatedWork W1904440676 @default.

• next