Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293728714> ?p ?o ?g. }
- W4293728714 abstract "Current evidence highlights the critical role of the gut-kidney axis in the pathogenesis of IgA nephropathy (IgAN). However, few attempts have been made to explore targeted intestinal immunity therapy. This research aims to develop an oral intestine targeting medication based on extracellular vesicles (EVs) and investigate its therapeutic efficacy in IgAN. EVs were isolated from orange juice and electroporated with dexamethasone sodium phosphate (DexP). After oral administration, EVs-DexP was picked up by lymphocytes in the submucosal area of ileocecum. EVs-DexP outperformed DexP not only in suppressing lymphocyte stimulation in vitro but also in alleviating renal pathological lesions in the IgAN mouse model. Clinical improvement was accompanied by a reducing IgA secreted by the intestine and a decreasing IgA + B220 + lymphocytes in Peyer’s patches. The present study develops a cost-effective, biofriendly EVs-based glucocorticoid strategy for IgAN." @default.
- W4293728714 created "2022-08-31" @default.
- W4293728714 creator A5000366782 @default.
- W4293728714 creator A5007658109 @default.
- W4293728714 creator A5009232538 @default.
- W4293728714 creator A5012858566 @default.
- W4293728714 creator A5030732785 @default.
- W4293728714 creator A5057150859 @default.
- W4293728714 creator A5070956574 @default.
- W4293728714 date "2022-08-31" @default.
- W4293728714 modified "2023-10-18" @default.
- W4293728714 title "Orange-derived and dexamethasone-encapsulated extracellular vesicles reduced proteinuria and alleviated pathological lesions in IgA nephropathy by targeting intestinal lymphocytes" @default.
- W4293728714 cites W1773874353 @default.
- W4293728714 cites W2079362912 @default.
- W4293728714 cites W2101794801 @default.
- W4293728714 cites W2102664661 @default.
- W4293728714 cites W2105251923 @default.
- W4293728714 cites W2110826783 @default.
- W4293728714 cites W2113765407 @default.
- W4293728714 cites W2119503603 @default.
- W4293728714 cites W2123819852 @default.
- W4293728714 cites W2134173784 @default.
- W4293728714 cites W2141675485 @default.
- W4293728714 cites W2151231994 @default.
- W4293728714 cites W2159666276 @default.
- W4293728714 cites W2165054263 @default.
- W4293728714 cites W2171525876 @default.
- W4293728714 cites W2178935826 @default.
- W4293728714 cites W2212745154 @default.
- W4293728714 cites W2296194067 @default.
- W4293728714 cites W2340580991 @default.
- W4293728714 cites W2433359959 @default.
- W4293728714 cites W2508982637 @default.
- W4293728714 cites W2546983796 @default.
- W4293728714 cites W2557141247 @default.
- W4293728714 cites W2588236705 @default.
- W4293728714 cites W2591683990 @default.
- W4293728714 cites W2600347335 @default.
- W4293728714 cites W2741457765 @default.
- W4293728714 cites W2948893547 @default.
- W4293728714 cites W3005104290 @default.
- W4293728714 cites W3032673817 @default.
- W4293728714 doi "https://doi.org/10.3389/fimmu.2022.900963" @default.
- W4293728714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36119039" @default.
- W4293728714 hasPublicationYear "2022" @default.
- W4293728714 type Work @default.
- W4293728714 citedByCount "4" @default.
- W4293728714 countsByYear W42937287142022 @default.
- W4293728714 countsByYear W42937287142023 @default.
- W4293728714 crossrefType "journal-article" @default.
- W4293728714 hasAuthorship W4293728714A5000366782 @default.
- W4293728714 hasAuthorship W4293728714A5007658109 @default.
- W4293728714 hasAuthorship W4293728714A5009232538 @default.
- W4293728714 hasAuthorship W4293728714A5012858566 @default.
- W4293728714 hasAuthorship W4293728714A5030732785 @default.
- W4293728714 hasAuthorship W4293728714A5057150859 @default.
- W4293728714 hasAuthorship W4293728714A5070956574 @default.
- W4293728714 hasBestOaLocation W42937287141 @default.
- W4293728714 hasConcept C104317684 @default.
- W4293728714 hasConcept C126322002 @default.
- W4293728714 hasConcept C134018914 @default.
- W4293728714 hasConcept C142724271 @default.
- W4293728714 hasConcept C145059251 @default.
- W4293728714 hasConcept C203014093 @default.
- W4293728714 hasConcept C20518536 @default.
- W4293728714 hasConcept C207886595 @default.
- W4293728714 hasConcept C2780091579 @default.
- W4293728714 hasConcept C2780368995 @default.
- W4293728714 hasConcept C2780401358 @default.
- W4293728714 hasConcept C2781184683 @default.
- W4293728714 hasConcept C2908689518 @default.
- W4293728714 hasConcept C55493867 @default.
- W4293728714 hasConcept C555293320 @default.
- W4293728714 hasConcept C71924100 @default.
- W4293728714 hasConcept C86803240 @default.
- W4293728714 hasConceptScore W4293728714C104317684 @default.
- W4293728714 hasConceptScore W4293728714C126322002 @default.
- W4293728714 hasConceptScore W4293728714C134018914 @default.
- W4293728714 hasConceptScore W4293728714C142724271 @default.
- W4293728714 hasConceptScore W4293728714C145059251 @default.
- W4293728714 hasConceptScore W4293728714C203014093 @default.
- W4293728714 hasConceptScore W4293728714C20518536 @default.
- W4293728714 hasConceptScore W4293728714C207886595 @default.
- W4293728714 hasConceptScore W4293728714C2780091579 @default.
- W4293728714 hasConceptScore W4293728714C2780368995 @default.
- W4293728714 hasConceptScore W4293728714C2780401358 @default.
- W4293728714 hasConceptScore W4293728714C2781184683 @default.
- W4293728714 hasConceptScore W4293728714C2908689518 @default.
- W4293728714 hasConceptScore W4293728714C55493867 @default.
- W4293728714 hasConceptScore W4293728714C555293320 @default.
- W4293728714 hasConceptScore W4293728714C71924100 @default.
- W4293728714 hasConceptScore W4293728714C86803240 @default.
- W4293728714 hasFunder F4320321001 @default.
- W4293728714 hasLocation W42937287141 @default.
- W4293728714 hasLocation W42937287142 @default.
- W4293728714 hasLocation W42937287143 @default.
- W4293728714 hasOpenAccess W4293728714 @default.
- W4293728714 hasPrimaryLocation W42937287141 @default.
- W4293728714 hasRelatedWork W190387045 @default.
- W4293728714 hasRelatedWork W2360463358 @default.