Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293728835> ?p ?o ?g. }
- W4293728835 abstract "Abstract Long non-coding RNAs (lncRNAs) are involved in breast cancer pathogenesis through chromatin remodeling, transcriptional and post-transcriptional gene regulation. We report robust associations between lncRNA expression and breast cancer clinicopathological features in two population-based cohorts: SCAN-B and TCGA. Using co-expression analysis of lncRNAs with protein coding genes, we discovered three distinct clusters of lncRNAs. In silico cell type deconvolution coupled with single-cell RNA-seq analyses revealed that these three clusters were driven by cell type specific expression of lncRNAs. In one cluster lncRNAs were expressed by cancer cells and were mostly associated with the estrogen signaling pathways. In the two other clusters, lncRNAs were expressed either by immune cells or fibroblasts of the tumor microenvironment. To further investigate the cis-regulatory regions driving lncRNA expression in breast cancer, we identified subtype-specific transcription factor (TF) occupancy at lncRNA promoters. We also integrated lncRNA expression with DNA methylation data to identify long-range regulatory regions for lncRNA which were validated using ChiA-Pet-Pol2 loops. lncRNAs play an important role in shaping the gene regulatory landscape in breast cancer. We provide a detailed subtype and cell type-specific expression of lncRNA, which improves the understanding of underlying transcriptional regulation in breast cancer." @default.
- W4293728835 created "2022-08-31" @default.
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- W4293728835 date "2022-08-18" @default.
- W4293728835 modified "2023-09-30" @default.
- W4293728835 title "Subtype and cell type specific expression of lncRNAs provide insight into breast cancer" @default.
- W4293728835 cites W1519070462 @default.
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- W4293728835 cites W2011463791 @default.
- W4293728835 cites W2012935431 @default.
- W4293728835 cites W2015162003 @default.
- W4293728835 cites W2017844161 @default.
- W4293728835 cites W2029919331 @default.
- W4293728835 cites W2035077913 @default.
- W4293728835 cites W2044702943 @default.
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- W4293728835 cites W2096283457 @default.
- W4293728835 cites W2102619694 @default.
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- W4293728835 cites W2115528316 @default.
- W4293728835 cites W2125342106 @default.
- W4293728835 cites W2130410032 @default.
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- W4293728835 cites W2145025818 @default.
- W4293728835 cites W2146573461 @default.
- W4293728835 cites W2152144700 @default.
- W4293728835 cites W2153091158 @default.
- W4293728835 cites W2160333540 @default.
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- W4293728835 cites W2166037178 @default.
- W4293728835 cites W2184563578 @default.
- W4293728835 cites W2197124664 @default.
- W4293728835 cites W2214074259 @default.
- W4293728835 cites W2230320310 @default.
- W4293728835 cites W2323326409 @default.
- W4293728835 cites W2524206229 @default.
- W4293728835 cites W2560367415 @default.
- W4293728835 cites W2593488635 @default.
- W4293728835 cites W2601262142 @default.
- W4293728835 cites W2641818139 @default.
- W4293728835 cites W2742662638 @default.
- W4293728835 cites W2766526974 @default.
- W4293728835 cites W2767298835 @default.
- W4293728835 cites W2767743008 @default.
- W4293728835 cites W2788248735 @default.
- W4293728835 cites W2795441251 @default.
- W4293728835 cites W2800773898 @default.
- W4293728835 cites W2810287056 @default.
- W4293728835 cites W2885900705 @default.
- W4293728835 cites W2888500336 @default.
- W4293728835 cites W2895653425 @default.
- W4293728835 cites W2898215009 @default.
- W4293728835 cites W2898316705 @default.
- W4293728835 cites W2950595506 @default.
- W4293728835 cites W2950833407 @default.
- W4293728835 cites W2951699110 @default.
- W4293728835 cites W2952001873 @default.
- W4293728835 cites W2969520627 @default.
- W4293728835 cites W2974257601 @default.
- W4293728835 cites W2988716798 @default.
- W4293728835 cites W2989281952 @default.