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- W4293732142 abstract "Nucleation is the rate-determining step in the kinetics of many self-assembly processes. However, the importance of nucleation in the kinetics of DNA-origami self-assembly, which involves both the binding of staple strands and the folding of the scaffold strand, is unclear. Here, using Monte Carlo simulations of a lattice model of DNA origami, we find that some, but not all, designs can have a nucleation barrier and that this barrier disappears at lower temperatures, rationalizing the success of isothermal assembly. We show that the height of the nucleation barrier depends primarily on the coaxial stacking of staples that are adjacent on the same helix, a parameter that can be modified with staple design. Creating a nucleation barrier to DNA-origami assembly could be useful in optimizing assembly times and yields, while eliminating the barrier may allow for fast molecular sensors that can assemble/disassemble without hysteresis in response to changes in the environment." @default.
- W4293732142 created "2022-08-31" @default.
- W4293732142 creator A5027924966 @default.
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- W4293732142 date "2022-08-29" @default.
- W4293732142 modified "2023-09-26" @default.
- W4293732142 title "Simulations of DNA-Origami Self-Assembly Reveal Design-Dependent Nucleation Barriers" @default.
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- W4293732142 doi "https://doi.org/10.1021/acs.nanolett.2c01372" @default.
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