Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293733689> ?p ?o ?g. }
- W4293733689 abstract "ABSTRACT During development, Hox genes are activated in a time sequence following their relative positions on their clusters, leading to the proper identities of structures along the rostral to caudal axis. To understand the mechanism operating this Hox timer, we used ES-cells derived stembryos and show that the core of the process involves the start of transcription at the 3’ part of the cluster, following Wnt signaling, and the concomitant loading of cohesin complexes on the transcribed DNA segments, i.e., with an asymmetric distribution along the gene cluster. Chromatin extrusion then occurs with successively more posterior CTCF sites acting as transient insulators, thus generating a progressive time-delay in the activation of more 5’-located genes due to long-range contacts with a flanking TAD. Mutant stembryos support this model and reveal that the iterated presence of evolutionary conserved and regularly spaced intergenic CTCF sites control the precision and the pace of this temporal mechanism." @default.
- W4293733689 created "2022-08-31" @default.
- W4293733689 creator A5005224351 @default.
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- W4293733689 date "2022-08-29" @default.
- W4293733689 modified "2023-10-03" @default.
- W4293733689 title "Sequential And Directional Insulation By Conserved CTCF Sites Underlies The <i>Hox</i> Timer In Pseudo-Embryos" @default.
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- W4293733689 doi "https://doi.org/10.1101/2022.08.29.505673" @default.
- W4293733689 hasPublicationYear "2022" @default.
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