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• W4293740981 abstract "The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (RTKs) consists of EGFR, ErbB2, ErbB3, and ErbB4. These receptors play key roles in cell proliferation, angiogenesis, cell migration, and in some cases, tumor promotion. ErbB4 is a unique member of the EGFR family, implicated not only in pro-tumorigenic mechanisms, such as cell proliferation and migration, but also in anti-tumorigenic activities, including cell differentiation and apoptosis. ErbB4 is differentially expressed in a wide variety of tissues, and interestingly, as different isoforms that result in vastly different signalling outcomes. Most studies have either ignored the presence of these isoforms or used overexpression models that may mask the true function of ErbB4. ErbB4 is widely expressed throughout the body with significant expression in skeletal tissue, mammary glands, heart, and brain. Knockout models have demonstrated embryonic lethality due to disrupted heart and brain development. Despite high expression in the brain and a critical role in brain development, remarkably little is known about the potential signalling activity of ErbB4 in brain cancer.This review focuses on the unique biology of ErbB4 in the brain, and in particular, highlights brain cancer research findings. We end the review with a focus on high grade gliomas, primarily glioblastoma, a disease that has been shown to involve EGFR and its mutant forms. The role of the different ErbB4 isotypes in high grade gliomas is still unclear and future research will hopefully shed some light on this question." @default.
• W4293740981 created "2022-08-31" @default.
• W4293740981 creator A5004460402 @default.
• W4293740981 creator A5020954253 @default.
• W4293740981 creator A5035346778 @default.
• W4293740981 creator A5048987396 @default.
• W4293740981 date "2022-08-31" @default.
• W4293740981 modified "2023-10-14" @default.
• W4293740981 title "ErbB4 in the brain: Focus on high grade glioma" @default.
• W4293740981 cites W13460688 @default.
• W4293740981 cites W1511174464 @default.
• W4293740981 cites W1550092936 @default.
• W4293740981 cites W1550107279 @default.
• W4293740981 cites W1550686038 @default.
• W4293740981 cites W1562926557 @default.
• W4293740981 cites W1580361048 @default.
• W4293740981 cites W1784466036 @default.
• W4293740981 cites W1797642366 @default.
• W4293740981 cites W181910992 @default.
• W4293740981 cites W1963939757 @default.
• W4293740981 cites W1964238015 @default.
• W4293740981 cites W1966803171 @default.
• W4293740981 cites W1973310884 @default.
• W4293740981 cites W1977768257 @default.
• W4293740981 cites W1984259400 @default.
• W4293740981 cites W1985103551 @default.
• W4293740981 cites W1989297227 @default.
• W4293740981 cites W1997914540 @default.
• W4293740981 cites W2006257247 @default.
• W4293740981 cites W2010735491 @default.
• W4293740981 cites W2016010426 @default.
• W4293740981 cites W2016717347 @default.
• W4293740981 cites W2018169163 @default.
• W4293740981 cites W2020237866 @default.
• W4293740981 cites W2022816733 @default.
• W4293740981 cites W2023527463 @default.
• W4293740981 cites W2023578257 @default.
• W4293740981 cites W2023775321 @default.
• W4293740981 cites W2024348320 @default.
• W4293740981 cites W2025029856 @default.
• W4293740981 cites W2031755128 @default.
• W4293740981 cites W2032301755 @default.
• W4293740981 cites W2034887388 @default.
• W4293740981 cites W2036387229 @default.
• W4293740981 cites W2038661578 @default.
• W4293740981 cites W2040730218 @default.
• W4293740981 cites W2042229191 @default.
• W4293740981 cites W2043345702 @default.
• W4293740981 cites W2043467783 @default.
• W4293740981 cites W2048564205 @default.
• W4293740981 cites W2057570788 @default.
• W4293740981 cites W2058411038 @default.
• W4293740981 cites W2058836795 @default.
• W4293740981 cites W2059666547 @default.
• W4293740981 cites W2064313800 @default.
• W4293740981 cites W2070715397 @default.
• W4293740981 cites W2071033930 @default.
• W4293740981 cites W2071387897 @default.
• W4293740981 cites W2075059021 @default.
• W4293740981 cites W2075910859 @default.
• W4293740981 cites W2075935381 @default.
• W4293740981 cites W2076682664 @default.
• W4293740981 cites W2080399383 @default.
• W4293740981 cites W2082223583 @default.
• W4293740981 cites W2083669410 @default.
• W4293740981 cites W2083831897 @default.
• W4293740981 cites W2084529417 @default.
• W4293740981 cites W2086785010 @default.
• W4293740981 cites W2090556834 @default.
• W4293740981 cites W2092897704 @default.
• W4293740981 cites W2093440393 @default.
• W4293740981 cites W2094313894 @default.
• W4293740981 cites W2097333356 @default.
• W4293740981 cites W2100244818 @default.
• W4293740981 cites W2103634963 @default.
• W4293740981 cites W2109816625 @default.
• W4293740981 cites W2112369586 @default.
• W4293740981 cites W2115736838 @default.
• W4293740981 cites W2116790599 @default.
• W4293740981 cites W2118579930 @default.
• W4293740981 cites W2118907340 @default.
• W4293740981 cites W2121136307 @default.
• W4293740981 cites W2122788299 @default.
• W4293740981 cites W2122918415 @default.
• W4293740981 cites W2123206362 @default.
• W4293740981 cites W2123415105 @default.
• W4293740981 cites W2125705356 @default.
• W4293740981 cites W2128899175 @default.
• W4293740981 cites W2131192891 @default.
• W4293740981 cites W2135198700 @default.
• W4293740981 cites W2140840142 @default.
• W4293740981 cites W2142145420 @default.
• W4293740981 cites W2143208627 @default.
• W4293740981 cites W2143923065 @default.
• W4293740981 cites W2145033700 @default.
• W4293740981 cites W2145755261 @default.
• W4293740981 cites W2148364504 @default.
• W4293740981 cites W2161641617 @default.
• W4293740981 cites W2163405576 @default.
• W4293740981 cites W2166655074 @default.

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