Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293744131> ?p ?o ?g. }
- W4293744131 endingPage "101628" @default.
- W4293744131 startingPage "101628" @default.
- W4293744131 abstract "The use of inorganic nanomaterials to tackle and exploit the intrinsic chemical nature of the tumor microenvironment (TME) has emerged as a promising strategy in cancer therapy. Manganese oxide nanoparticles (MnxOy) offer unique advantages in terms of redox properties and specificity towards the TME scenario: low O2 concentrations, mildly acidic pH and high oxidative stress; environmental conditions that often lead to a reduction in the efficacy of cancer treatments. MnxOy-based nanoplatforms have recently demonstrated exciting properties as inorganic nanocatalysts to operate under TME constraints. Alternatively, Mn-nanocatalysts have also displayed synergistic anticancer response in combination with other active co-adjuvant elements (drugs, enzymes or nanomaterials). The aim of this review is to provide new insights on the main functionalities of Mn-based nanomaterials applied to cancer therapy. We analyze its capacity as oxygen supplier in hypoxic scenarios, its role to induce the selective depletion of glutathione (GSH) to maximize cell stress or its capacity to promote starvation therapy via glucose oxidation. We aim at providing an insightful view of the operating mechanisms behind each of these critical processes and highlight the versatility and catalytic richness of Mn-based nanoparticles in this developing field. We also provide a general and comprehensive analysis of the Mn fate when trafficking through the intracellular levels." @default.
- W4293744131 created "2022-08-31" @default.
- W4293744131 creator A5065972127 @default.
- W4293744131 creator A5079033791 @default.
- W4293744131 creator A5089436555 @default.
- W4293744131 date "2022-12-01" @default.
- W4293744131 modified "2023-10-12" @default.
- W4293744131 title "Manganese oxide nano-platforms in cancer therapy: Recent advances on the development of synergistic strategies targeting the tumor microenvironment" @default.
- W4293744131 cites W1480357432 @default.
- W4293744131 cites W1507021713 @default.
- W4293744131 cites W1538902372 @default.
- W4293744131 cites W1667606852 @default.
- W4293744131 cites W1949636578 @default.
- W4293744131 cites W1957283931 @default.
- W4293744131 cites W1975129370 @default.
- W4293744131 cites W1976652877 @default.
- W4293744131 cites W1983228601 @default.
- W4293744131 cites W1984383995 @default.
- W4293744131 cites W1997479687 @default.
- W4293744131 cites W2004354097 @default.
- W4293744131 cites W2007185373 @default.
- W4293744131 cites W2010335080 @default.
- W4293744131 cites W2010407977 @default.
- W4293744131 cites W2014058353 @default.
- W4293744131 cites W2026776474 @default.
- W4293744131 cites W2038636572 @default.
- W4293744131 cites W2049453516 @default.
- W4293744131 cites W2051708290 @default.
- W4293744131 cites W2058183968 @default.
- W4293744131 cites W2058461613 @default.
- W4293744131 cites W2066411725 @default.
- W4293744131 cites W2067127926 @default.
- W4293744131 cites W2071255536 @default.
- W4293744131 cites W2078394930 @default.
- W4293744131 cites W2088532808 @default.
- W4293744131 cites W2089576393 @default.
- W4293744131 cites W2092434707 @default.
- W4293744131 cites W2096258216 @default.
- W4293744131 cites W2097259163 @default.
- W4293744131 cites W2102451023 @default.
- W4293744131 cites W2115504979 @default.
- W4293744131 cites W2116567644 @default.
- W4293744131 cites W2118471749 @default.
- W4293744131 cites W2121526477 @default.
- W4293744131 cites W2129302190 @default.
- W4293744131 cites W2129778797 @default.
- W4293744131 cites W2130547709 @default.
- W4293744131 cites W2135284562 @default.
- W4293744131 cites W2142644858 @default.
- W4293744131 cites W2149360266 @default.
- W4293744131 cites W2156265559 @default.
- W4293744131 cites W2161431747 @default.
- W4293744131 cites W2165836181 @default.
- W4293744131 cites W2168083201 @default.
- W4293744131 cites W2170913114 @default.
- W4293744131 cites W2189968318 @default.
- W4293744131 cites W2221725862 @default.
- W4293744131 cites W2223535266 @default.
- W4293744131 cites W2236457000 @default.
- W4293744131 cites W2265419075 @default.
- W4293744131 cites W2300006817 @default.
- W4293744131 cites W2305745682 @default.
- W4293744131 cites W2309208903 @default.
- W4293744131 cites W2401893904 @default.
- W4293744131 cites W2413193118 @default.
- W4293744131 cites W2418560736 @default.
- W4293744131 cites W2489121689 @default.
- W4293744131 cites W2504396398 @default.
- W4293744131 cites W2537847790 @default.
- W4293744131 cites W2555200685 @default.
- W4293744131 cites W2560612571 @default.
- W4293744131 cites W2597618526 @default.
- W4293744131 cites W2612358593 @default.
- W4293744131 cites W2614585289 @default.
- W4293744131 cites W2615993918 @default.
- W4293744131 cites W2626318019 @default.
- W4293744131 cites W2737866071 @default.
- W4293744131 cites W2755562689 @default.
- W4293744131 cites W2756282825 @default.
- W4293744131 cites W2764028271 @default.
- W4293744131 cites W2769217722 @default.
- W4293744131 cites W2772326466 @default.
- W4293744131 cites W2779282509 @default.
- W4293744131 cites W2782493592 @default.
- W4293744131 cites W2790380857 @default.
- W4293744131 cites W2793503277 @default.
- W4293744131 cites W2793742898 @default.
- W4293744131 cites W2793815895 @default.
- W4293744131 cites W2794877002 @default.
- W4293744131 cites W2796106907 @default.
- W4293744131 cites W2796962120 @default.
- W4293744131 cites W2798209291 @default.
- W4293744131 cites W2802706546 @default.
- W4293744131 cites W2804377836 @default.
- W4293744131 cites W2805859772 @default.
- W4293744131 cites W2806940039 @default.
- W4293744131 cites W2883477868 @default.
- W4293744131 cites W2884605745 @default.