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• W4293749420 endingPage "14837" @default.
• W4293749420 startingPage "14827" @default.
• W4293749420 abstract "Sialic acid (SA) is overexpressed on cell membranes of tumor cells, and increased serum SA concentration has been observed in tumor-bearing patients. Herein, a series of lanthanide-containing bimetallic complexes (TDA-M-Lns) for targeting SA were prepared via coordination among luminescent lanthanide ions (Ln3+ = Tb3+, Eu3+, Dy3+, or Sm3+), metal ion quenchers (M2+ = Cu2+ or Co2+), and the organic ligand 2,2'-thiodiacetic acid (TDA). SA can competitively coordinate with Ln3+, resulting in the signal-on of the Ln3+. Therefore, the TDA-M-Lns can be simply used for cost-saving detection of SA in the blood samples. Among the TDA-M-Lns, TDA-Co-Eu showed the highest sensitivity to detect SA in the blood of tumor-bearing mice. Furthermore, the TDA-Co-Eu was successfully used to target SA and deposit Eu3+ on the surfaces of tumor cells for the inhibition of tumor cell growth and migration. The therapeutic effect of TDA-Co-Eu on a Balb/c mouse liver tumor model was evaluated. It was proved that TDA-Co-Eu can be applied for SA detection as well as for inhibiting tumor growth." @default.
• W4293749420 created "2022-08-31" @default.
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• W4293749420 date "2022-08-18" @default.
• W4293749420 modified "2023-10-15" @default.
• W4293749420 title "Lanthanide Complexes for Tumor Diagnosis and Therapy by Targeting Sialic Acid" @default.
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• W4293749420 doi "https://doi.org/10.1021/acsnano.2c05715" @default.
• W4293749420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35981089" @default.
• W4293749420 hasPublicationYear "2022" @default.
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