FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293761036> ?p ?o ?g. }

• W4293761036 endingPage "5488" @default.
• W4293761036 startingPage "5488" @default.
• W4293761036 abstract "Ischemic stroke triggers a whole cascade of pathological changes in the brain, one of which is postischemic inflammation. Since in such cases thrombolytic therapy is often not possible, methods that modulate inflammation and affect microglia become particularly interesting. We synthesized 3-(2-oxo-4-phenylpyrrolidin-1-yl)propane-1-sulfonate calcium(II) (Compound 4) and studied its anti-inflammatory activity in in vitro and in vivo models of inflammation and ischemia. Macrophage cell line RAW 264.7 was treated with lipopolysaccharides (LPS) and Compound 4 at various dosages to study the cytokine profile using real-time PCR and cytometric bead array (CBA). Stroke in rats was simulated by the middle cerebral artery occlusion method (MCAO). Several tests were performed to characterize the neurological deficit and locomotor activity of the rats, and afterwards, postmortem, the number of astrocytes was counted using immunohistochemistry. Compound 4 in in vitro tests dose-dependently reduced the expression of interleukin-1β (IL1β), and inducible nitric oxide synthase (iNOS) genes in cell culture and increased the concentration of cytokines: interleukin-2, 4, 6 (IL-2, IL-4, and IL-6). In vivo Compound 4 increased the orienting-exploratory behavior, and reduced neurological and motor deficit. The number of astrocytes that promote and support inflammation was lower in the group treated with Compound 4. The stroke volume measured by magnetic resonance imaging (MRI) showed no difference. We have shown that Compound 4 demonstrates anti-inflammatory activity by increasing the synthesis of anti-inflammatory and reducing pro-inflammatory cytokines, and positively affects the neurological deficit in rats. Thus, Compound 4 has a high therapeutic potential in the management of patients after a stroke and requires further study of its neuroprotective properties." @default.
• W4293761036 created "2022-08-31" @default.
• W4293761036 creator A5002895667 @default.
• W4293761036 creator A5004472812 @default.
• W4293761036 creator A5014422483 @default.
• W4293761036 creator A5019346295 @default.
• W4293761036 creator A5028525534 @default.
• W4293761036 creator A5031849483 @default.
• W4293761036 creator A5033637458 @default.
• W4293761036 creator A5056768555 @default.
• W4293761036 creator A5057327992 @default.
• W4293761036 creator A5058126602 @default.
• W4293761036 creator A5074313018 @default.
• W4293761036 creator A5079361111 @default.
• W4293761036 creator A5087369314 @default.
• W4293761036 creator A5087398537 @default.
• W4293761036 date "2022-08-26" @default.
• W4293761036 modified "2023-10-01" @default.
• W4293761036 title "The Effect of a New N-hetero Cycle Derivative on Behavior and Inflammation against the Background of Ischemic Stroke" @default.
• W4293761036 cites W1616163715 @default.
• W4293761036 cites W1917016997 @default.
• W4293761036 cites W1985557482 @default.
• W4293761036 cites W2000225733 @default.
• W4293761036 cites W2001542176 @default.
• W4293761036 cites W2024898599 @default.
• W4293761036 cites W2043644834 @default.
• W4293761036 cites W2059969895 @default.
• W4293761036 cites W2061144937 @default.
• W4293761036 cites W2074661552 @default.
• W4293761036 cites W2083004303 @default.
• W4293761036 cites W2124549591 @default.
• W4293761036 cites W2134729461 @default.
• W4293761036 cites W2147786049 @default.
• W4293761036 cites W2158667888 @default.
• W4293761036 cites W2160592638 @default.
• W4293761036 cites W2228927093 @default.
• W4293761036 cites W2512238452 @default.
• W4293761036 cites W2513420276 @default.
• W4293761036 cites W2748481656 @default.
• W4293761036 cites W2770455465 @default.
• W4293761036 cites W2793810469 @default.
• W4293761036 cites W2895115930 @default.
• W4293761036 cites W2898806645 @default.
• W4293761036 cites W2901382912 @default.
• W4293761036 cites W2906480617 @default.
• W4293761036 cites W2932848164 @default.
• W4293761036 cites W2946400547 @default.
• W4293761036 cites W2965183460 @default.
• W4293761036 cites W2969627715 @default.
• W4293761036 cites W3015536534 @default.
• W4293761036 cites W3042785217 @default.
• W4293761036 cites W3135994198 @default.
• W4293761036 cites W3160743591 @default.
• W4293761036 cites W3206225974 @default.
• W4293761036 cites W3213004408 @default.
• W4293761036 cites W4200608597 @default.
• W4293761036 cites W4283015702 @default.
• W4293761036 doi "https://doi.org/10.3390/molecules27175488" @default.
• W4293761036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36080256" @default.
• W4293761036 hasPublicationYear "2022" @default.
• W4293761036 type Work @default.
• W4293761036 citedByCount "2" @default.
• W4293761036 countsByYear W42937610362022 @default.
• W4293761036 countsByYear W42937610362023 @default.
• W4293761036 crossrefType "journal-article" @default.
• W4293761036 hasAuthorship W4293761036A5002895667 @default.
• W4293761036 hasAuthorship W4293761036A5004472812 @default.
• W4293761036 hasAuthorship W4293761036A5014422483 @default.
• W4293761036 hasAuthorship W4293761036A5019346295 @default.
• W4293761036 hasAuthorship W4293761036A5028525534 @default.
• W4293761036 hasAuthorship W4293761036A5031849483 @default.
• W4293761036 hasAuthorship W4293761036A5033637458 @default.
• W4293761036 hasAuthorship W4293761036A5056768555 @default.
• W4293761036 hasAuthorship W4293761036A5057327992 @default.
• W4293761036 hasAuthorship W4293761036A5058126602 @default.
• W4293761036 hasAuthorship W4293761036A5074313018 @default.
• W4293761036 hasAuthorship W4293761036A5079361111 @default.
• W4293761036 hasAuthorship W4293761036A5087369314 @default.
• W4293761036 hasAuthorship W4293761036A5087398537 @default.
• W4293761036 hasBestOaLocation W42937610361 @default.
• W4293761036 hasConcept C126322002 @default.
• W4293761036 hasConcept C127413603 @default.
• W4293761036 hasConcept C142724271 @default.
• W4293761036 hasConcept C150903083 @default.
• W4293761036 hasConcept C203014093 @default.
• W4293761036 hasConcept C207001950 @default.
• W4293761036 hasConcept C2776914184 @default.
• W4293761036 hasConcept C2777622882 @default.
• W4293761036 hasConcept C2778690821 @default.
• W4293761036 hasConcept C2779830541 @default.
• W4293761036 hasConcept C2780645631 @default.
• W4293761036 hasConcept C519581460 @default.
• W4293761036 hasConcept C71924100 @default.
• W4293761036 hasConcept C78519656 @default.
• W4293761036 hasConcept C86803240 @default.
• W4293761036 hasConcept C98274493 @default.
• W4293761036 hasConceptScore W4293761036C126322002 @default.
• W4293761036 hasConceptScore W4293761036C127413603 @default.

• next