FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293765524> ?p ?o ?g. }

• W4293765524 endingPage "1220" @default.
• W4293765524 startingPage "1218" @default.
• W4293765524 abstract "Recently, a case has been made for the safety, tolerability and clinical utility of accelerated protocol for tDCS (acctDCS) (greater number of sessions over a shorter duration) in schizophrenia [[1]Mondino M. Poulet E. Brunelin J. Moving to accelerated protocols of tDCS in schizophrenia: a case report.Brain Stimul. 2021; 14: 822-824Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar]. In this case report, we describe neurophysiological changes with acctDCS in (a) corollary discharge profile that is relevant to auditory hallucination (AH) pathophysiology and is a reliable indicator of tDCS treatment response [[2]Bose A. et al.Effect of fronto-temporal transcranial direct current stimulation on corollary discharge in schizophrenia: a randomized, double-blind, sham-controlled mediation analysis study.Schizophr Res. 2019; 204: 411-412Crossref PubMed Scopus (11) Google Scholar], and (b) prediction error signalling and short-term auditory neuroplasticity utilising a robust roving MMN (rMMN) paradigm [[3]McCleery A. et al.Hallucinations, neuroplasticity, and prediction errors in schizophrenia.Scand J Psychol. 2018; 59: 41-48Crossref PubMed Scopus (11) Google Scholar]. Ms S, a 33 years-old-female patient, presented to us with a six years history of second and third-person auditory hallucinations, alongside significant persecutory, referential, religious, and grandiose delusions. Psychopathology examination elicited derailment, tangentiality, word approximations and sometimes neologism in speech. Poor compliance to oral olanzapine during the first three years of illness prompted treatment with depot injection of olanzapine of 300mg/month for three years. Due to recent non-adherence with resultant worsening of symptoms, the dose of olanzapine injection was increased to 405mg/month for the previous two months; nonetheless, the patient persisted in being symptomatic. At baseline, Positive and Negative Syndrome Scale (PANSS) score was 137 (Positive Scale = 32; Negative Scale = 39; General psychopathology Scale = 66; Supplementary Table 1), and Auditory Hallucination Rating Scale (AHRS) score was 34. Because of significantly distressing symptoms requiring faster clinical improvement, the patient was treated with add-on acctDCS. AcctDCS protocol involved 10 sessions of 2mA direct current stimulation 20 minutes each over two consecutive days; 5 sessions/day with a 20-min inter-session interval using 7x5-cm electrodes covered with saline-soaked sponges; anode: left prefrontal; cathode: left temporo-parietal junction [[1]Mondino M. Poulet E. Brunelin J. Moving to accelerated protocols of tDCS in schizophrenia: a case report.Brain Stimul. 2021; 14: 822-824Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar]. The montage was kept constant across sessions, side effects were systematically monitored using a comprehensive checklist [[4]Brunoni A.R. et al.A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation.Int J Neuropsychopharmacol. 2011; 14: 1133-1145Crossref PubMed Scopus (700) Google Scholar]. Corollary discharge profile and short-term auditory plasticity were examined before and after acctDCS–using Corollary Discharge (CD) [[5]Ford J.M. Roach B.J. Mathalon D.H. Assessing corollary discharge in humans using noninvasive neurophysiological methods.Nat Protoc. 2010; 5: 1160-1168Crossref PubMed Scopus (56) Google Scholar] and Roving MMN (rMMN) [[6]McCleery A. et al.Parsing components of auditory predictive coding in schizophrenia using a roving standard mismatch negativity paradigm.Psychol Med. 2019; 49: 1195-1206Crossref PubMed Scopus (16) Google Scholar] event-related potential (ERP) paradigms as per the previous descriptions. The clinical outcome was assessed using AHRS and PANSS scales. The patient tolerated the sessions well, reported no side effects and indicated a significant (44%) reduction in AH severity (AHRS = 19). But, given persistent higher overall psychopathology (PANSS = 112), another three days (15 sessions) of acctDCS (2nd course) was administered following which further decline was noted in AH severity (AHRS = 17; 50% reduction from baseline). There was a gap of two days between the 1st and 2nd course of acctDCS sessions. Overall, 25 tDCS sessions (5-sessions/day) were given to the patient. Both ERP paradigms were repeated after 25 sessions. AcctDCS sessions were well-tolerated. At the start of the sessions, current appreciation was noted as a mild pricking sensation for a few sessions. An incremental response was noted in clinical symptoms from the 1st to the 2nd course of acctDCS, with a rapid reduction in AH in the first course but progressive improvement in negative and general psychopathology scores by the end of the 2nd course. (Supplementary Table 1). Both CD and rMMN profiles were aberrant at baseline (Fig. 1). CD is the ability of an organism to discount the sensory consequences of self-generated action [[5]Ford J.M. Roach B.J. Mathalon D.H. Assessing corollary discharge in humans using noninvasive neurophysiological methods.Nat Protoc. 2010; 5: 1160-1168Crossref PubMed Scopus (56) Google Scholar]. For auditory CD to be adequate, the Talk N100 amplitude should be attenuated (more + ve), indicating less responsiveness of the auditory cortex towards actively self-generated sounds. The Listen N100 amplitude should be robust (more -ve), indicating adequate arousal of the auditory cortex to passive speech sounds. At baseline, Talk and Listen N100 amplitudes were similar [Fig. 1(a). Talk = 0.58μV; Listen = 0.11μV] indicating neurophysiological activity linked to severe AH. Following the acctDCS-1st Course, the correction in the CD profile was prominent [Fig. 1(b). Talk = 2.04μV; Listen = −7.93μV]. This improvement persisted, albeit with lesser magnitude, after the acctDCS-2nd Course [Fig. 1(c). Talk = 0.22μV; Listen = −2.27μV]. The observed change in the CD profile indicates a correction of CD deficiency linked to the improvement of AH [[2]Bose A. et al.Effect of fronto-temporal transcranial direct current stimulation on corollary discharge in schizophrenia: a randomized, double-blind, sham-controlled mediation analysis study.Schizophr Res. 2019; 204: 411-412Crossref PubMed Scopus (11) Google Scholar]. rMMN is a nuanced measure of prediction error. In the rMMN paradigm, the deviant tone becomes the new standard over the course of stimuli presentation. The strength of prediction error signalling via the deviant stimuli varies as a function of the length of the standard stimuli's strain preceding it. rMMN paradigm allows examination of 1) repetition positivity (RP)–the strength of standard stimulus's memory trace that increases with repetition; 2) deviant negativity (DN)–the strength of prediction error signalling; and MMN that is derived from DN–RP [6]. The magnitude of prediction error signalling is higher when the train of preceding standard stimuli is longer. Stimuli differing in duration or frequency are presented in sets of 3, 8 and 33. Therefore, the expected MMN profile is MMN33>MMN8>MMN3 in the order of decreasing negativity of N1 amplitude. At baseline, the patient's rMMN profile notably deviated from the MMN33>MMN8>MMN3 pattern [Fig. 1(d)]. Following acctDCS-1st course, the correct pattern was established [Fig. 1(e)]. After the acctDCS-2nd Course, there was an enhancement of all MMN amplitudes (amplitudes became more -ve), indicating stronger prediction error signalling [Fig. 1(f)]. Correction of rMMN profile possibly reflects the ability of acctDCS to address deficient prediction error signalling and concomitant aberrant salience in schizophrenia. The present case study supports the safety, tolerability, and potential clinical utility of extended acctDCS (25 sessions over 5 days) for treating severe AH and psychopathology in schizophrenia. As indicated by the correction of CD and rMMN, acctDCS is capable of rapid neuroplasticity modulation that likely underscores the clinical benefit. Redressal of CD and rMMN profiles may have facilitated more accurate auditory signal processing leading to a reduction in AH and internal misrepresentations of environmental stimuli, paving the way for overall improvement in psychopathology. The incremental clinical and pathophysiological response noted over two courses of acctDCS could be a latent/delayed effect of the 1st course, and additional benefits of extended sessions need to be systematically studied. Future studies should compare the effect of acctDCS to standard tDCS for clinical benefit and potential for neuroplasticity modulation. This work is supported by the Department of Biotechnology (DBT) - Wellcome Trust India Alliance grants to GV (IA/CRC/19/1/610005) & AB (IA/CPHE/19/1/504591)." @default.
• W4293765524 created "2022-08-31" @default.
• W4293765524 creator A5027691262 @default.
• W4293765524 creator A5029501907 @default.
• W4293765524 creator A5030183183 @default.
• W4293765524 creator A5036438433 @default.
• W4293765524 creator A5043740765 @default.
• W4293765524 creator A5063679515 @default.
• W4293765524 creator A5067776807 @default.
• W4293765524 date "2022-09-01" @default.
• W4293765524 modified "2023-10-15" @default.
• W4293765524 title "Accelerated tDCS improves corollary discharge deficit & prediction error signalling in schizophrenia: A case report" @default.
• W4293765524 cites W2088992917 @default.
• W4293765524 cites W2163099466 @default.
• W4293765524 cites W2792321642 @default.
• W4293765524 cites W2885427412 @default.
• W4293765524 cites W2908547723 @default.
• W4293765524 cites W3160518708 @default.
• W4293765524 doi "https://doi.org/10.1016/j.brs.2022.08.014" @default.
• W4293765524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36041705" @default.
• W4293765524 hasPublicationYear "2022" @default.
• W4293765524 type Work @default.
• W4293765524 citedByCount "1" @default.
• W4293765524 countsByYear W42937655242023 @default.
• W4293765524 crossrefType "journal-article" @default.
• W4293765524 hasAuthorship W4293765524A5027691262 @default.
• W4293765524 hasAuthorship W4293765524A5029501907 @default.
• W4293765524 hasAuthorship W4293765524A5030183183 @default.
• W4293765524 hasAuthorship W4293765524A5036438433 @default.
• W4293765524 hasAuthorship W4293765524A5043740765 @default.
• W4293765524 hasAuthorship W4293765524A5063679515 @default.
• W4293765524 hasAuthorship W4293765524A5067776807 @default.
• W4293765524 hasBestOaLocation W42937655241 @default.
• W4293765524 hasConcept C105795698 @default.
• W4293765524 hasConcept C118552586 @default.
• W4293765524 hasConcept C144237770 @default.
• W4293765524 hasConcept C15744967 @default.
• W4293765524 hasConcept C167085575 @default.
• W4293765524 hasConcept C169760540 @default.
• W4293765524 hasConcept C202444582 @default.
• W4293765524 hasConcept C2776412080 @default.
• W4293765524 hasConcept C2780012671 @default.
• W4293765524 hasConcept C33923547 @default.
• W4293765524 hasConcept C39743133 @default.
• W4293765524 hasConceptScore W4293765524C105795698 @default.
• W4293765524 hasConceptScore W4293765524C118552586 @default.
• W4293765524 hasConceptScore W4293765524C144237770 @default.
• W4293765524 hasConceptScore W4293765524C15744967 @default.
• W4293765524 hasConceptScore W4293765524C167085575 @default.
• W4293765524 hasConceptScore W4293765524C169760540 @default.
• W4293765524 hasConceptScore W4293765524C202444582 @default.
• W4293765524 hasConceptScore W4293765524C2776412080 @default.
• W4293765524 hasConceptScore W4293765524C2780012671 @default.
• W4293765524 hasConceptScore W4293765524C33923547 @default.
• W4293765524 hasConceptScore W4293765524C39743133 @default.
• W4293765524 hasFunder F4320320717 @default.
• W4293765524 hasFunder F4320320720 @default.
• W4293765524 hasFunder F4320322030 @default.
• W4293765524 hasFunder F4320322120 @default.
• W4293765524 hasFunder F4320325580 @default.
• W4293765524 hasIssue "5" @default.
• W4293765524 hasLocation W42937655241 @default.
• W4293765524 hasLocation W42937655242 @default.
• W4293765524 hasLocation W42937655243 @default.
• W4293765524 hasOpenAccess W4293765524 @default.
• W4293765524 hasPrimaryLocation W42937655241 @default.
• W4293765524 hasRelatedWork W2006955019 @default.
• W4293765524 hasRelatedWork W2034651412 @default.
• W4293765524 hasRelatedWork W2047416352 @default.
• W4293765524 hasRelatedWork W2068181401 @default.
• W4293765524 hasRelatedWork W2094037592 @default.
• W4293765524 hasRelatedWork W2135848692 @default.
• W4293765524 hasRelatedWork W2148733684 @default.
• W4293765524 hasRelatedWork W2505324626 @default.
• W4293765524 hasRelatedWork W2951173090 @default.
• W4293765524 hasRelatedWork W4383860563 @default.
• W4293765524 hasVolume "15" @default.
• W4293765524 isParatext "false" @default.
• W4293765524 isRetracted "false" @default.
• W4293765524 workType "article" @default.