Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293765970> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4293765970 endingPage "24" @default.
- W4293765970 startingPage "18" @default.
- W4293765970 abstract "Tumor transformation of immunocompetent cells in patients with chronic lymphoproliferative diseases (CLPD) leads to the formation of secondary immune deficiency, which increases the prevalence of infectious complications. Whether the presence of hepatitis C virus (HCV) and the formation of chronic hepatitis (HCV) further weaken the immunoreactivity of the patient, remains poorly understood. The purpose of this work was to reveal the patterns of HCG formation in patients with CLPD with a detailed analysis of immune disorders associated with the chronicity of viral hepatitis C. Another aim of the study was to disclose the patterns of HCG formation in patients with CLP with a detailed analysis of immune disorders associated with the chronicity of viral hepatitis C. The comparative assessment of immunological and biochemical parameters was carried out in 110 patients with HCV (85 – chronic lymphocytic leukemia, 25 – non- Hodgkin lymphoma), with the presence of hepatitis C virus markers (n=20) and 90 patients negative for HCV. To identify intergroup differences, the method of nonparametric statistics was used: the Mann-Whitney criterion. Results. It was found that the group of HCV-infected patients is represented by younger persons compared to uninfected patients (median age – 44 years vs. 60 years, p=0.004). Analyzing the state of the immune system, we have revealed that regardless of the presence of chronic hepatitis C, all patients had a defect in both cellular and humoral immunity. The degree of immune deficiency did not have a direct dependence on viral liver damage. Moreover, in the presence of HCV infection, there was an increase in the microbicidal activity of neutrophils, as well as an increase in the expression of CD95+ on lymphoid cells. Cytokine levels during HCV contamination fluctuated in different directions. There was an increase in the level of ALT in the group of patients with HCV. Findings. The formation of immune deficiency in patients with CLPD is largely associated with the presence of oncopathology and practically does not depend on the presence of chronic hepatitis C." @default.
- W4293765970 created "2022-08-31" @default.
- W4293765970 creator A5047628270 @default.
- W4293765970 creator A5068638177 @default.
- W4293765970 creator A5074064468 @default.
- W4293765970 creator A5074736148 @default.
- W4293765970 date "2021-04-01" @default.
- W4293765970 modified "2023-10-14" @default.
- W4293765970 title "Features of the immune status in chronic hepatitis C in patients with lymphopriliferative diseases" @default.
- W4293765970 doi "https://doi.org/10.14427/jipai.2021.2.18" @default.
- W4293765970 hasPublicationYear "2021" @default.
- W4293765970 type Work @default.
- W4293765970 citedByCount "0" @default.
- W4293765970 crossrefType "journal-article" @default.
- W4293765970 hasAuthorship W4293765970A5047628270 @default.
- W4293765970 hasAuthorship W4293765970A5068638177 @default.
- W4293765970 hasAuthorship W4293765970A5074064468 @default.
- W4293765970 hasAuthorship W4293765970A5074736148 @default.
- W4293765970 hasBestOaLocation W42937659701 @default.
- W4293765970 hasConcept C137061746 @default.
- W4293765970 hasConcept C202751555 @default.
- W4293765970 hasConcept C203014093 @default.
- W4293765970 hasConcept C2522874641 @default.
- W4293765970 hasConcept C2776029263 @default.
- W4293765970 hasConcept C2776408679 @default.
- W4293765970 hasConcept C2776455275 @default.
- W4293765970 hasConcept C2776969849 @default.
- W4293765970 hasConcept C2776995267 @default.
- W4293765970 hasConcept C2777072776 @default.
- W4293765970 hasConcept C2779338263 @default.
- W4293765970 hasConcept C55493867 @default.
- W4293765970 hasConcept C71924100 @default.
- W4293765970 hasConcept C86803240 @default.
- W4293765970 hasConcept C8891405 @default.
- W4293765970 hasConceptScore W4293765970C137061746 @default.
- W4293765970 hasConceptScore W4293765970C202751555 @default.
- W4293765970 hasConceptScore W4293765970C203014093 @default.
- W4293765970 hasConceptScore W4293765970C2522874641 @default.
- W4293765970 hasConceptScore W4293765970C2776029263 @default.
- W4293765970 hasConceptScore W4293765970C2776408679 @default.
- W4293765970 hasConceptScore W4293765970C2776455275 @default.
- W4293765970 hasConceptScore W4293765970C2776969849 @default.
- W4293765970 hasConceptScore W4293765970C2776995267 @default.
- W4293765970 hasConceptScore W4293765970C2777072776 @default.
- W4293765970 hasConceptScore W4293765970C2779338263 @default.
- W4293765970 hasConceptScore W4293765970C55493867 @default.
- W4293765970 hasConceptScore W4293765970C71924100 @default.
- W4293765970 hasConceptScore W4293765970C86803240 @default.
- W4293765970 hasConceptScore W4293765970C8891405 @default.
- W4293765970 hasIssue "2" @default.
- W4293765970 hasLocation W42937659701 @default.
- W4293765970 hasOpenAccess W4293765970 @default.
- W4293765970 hasPrimaryLocation W42937659701 @default.
- W4293765970 hasRelatedWork W1499433260 @default.
- W4293765970 hasRelatedWork W1966056365 @default.
- W4293765970 hasRelatedWork W1987769824 @default.
- W4293765970 hasRelatedWork W2030238129 @default.
- W4293765970 hasRelatedWork W2034841682 @default.
- W4293765970 hasRelatedWork W2045903301 @default.
- W4293765970 hasRelatedWork W2066817493 @default.
- W4293765970 hasRelatedWork W4235919785 @default.
- W4293765970 hasRelatedWork W4293765970 @default.
- W4293765970 hasRelatedWork W2019697373 @default.
- W4293765970 hasVolume "2021" @default.
- W4293765970 isParatext "false" @default.
- W4293765970 isRetracted "false" @default.
- W4293765970 workType "article" @default.