FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293769218> ?p ?o ?g. }

• W4293769218 abstract "Abstract Multiparental populations (MPPs) encompass greater genetic diversity than traditional experimental crosses of two inbred strains, enabling broader surveys of genetic variation underlying complex traits. Two such mouse MPPs are the Collaborative Cross (CC) inbred panel and the Diversity Outbred (DO) population, which are descended from the same eight inbred strains. Additionally, the F1 intercrosses of CC strains (CC-RIX) have been used and enable study designs with replicate outbred mice. Genetic analyses commonly used by researchers to investigate complex traits in these populations include characterizing how heritable a trait is, i . e ., its heritability, and mapping its underlying genetic loci, i . e ., its quantitative trait loci (QTLs). Here we evaluate the relative merits of these populations for these tasks through simulation, as well as provide recommendations for performing the quantitative genetic analyses. We find that sample populations that include replicate animals, as possible with the CC and CC-RIX, provide more efficient and precise estimates of heritability. We report QTL mapping power curves for the CC, CC-RIX, and DO across a range of QTL effect sizes and polygenic backgrounds for samples of 174 and 500 mice. The utility of replicate animals in the CC and CC-RIX for mapping QTLs rapidly decreased as traits became more polygenic. Only large sample populations of 500 DO mice were well-powered to detect smaller effect loci (7.5-10%) for highly complex traits (80% polygenic background). All results were generated with our R package musppr, which we developed to simulate data from these MPPs and evaluate genetic analyses from user-provided genotypes." @default.
• W4293769218 created "2022-08-31" @default.
• W4293769218 creator A5026731530 @default.
• W4293769218 date "2022-08-26" @default.
• W4293769218 modified "2023-10-13" @default.
• W4293769218 title "Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population" @default.
• W4293769218 cites W1807892535 @default.
• W4293769218 cites W1900943334 @default.
• W4293769218 cites W1927774076 @default.
• W4293769218 cites W1939671230 @default.
• W4293769218 cites W1970726947 @default.
• W4293769218 cites W1989804913 @default.
• W4293769218 cites W1999935373 @default.
• W4293769218 cites W2000084758 @default.
• W4293769218 cites W2002106319 @default.
• W4293769218 cites W2004882302 @default.
• W4293769218 cites W2022325653 @default.
• W4293769218 cites W2034608799 @default.
• W4293769218 cites W2037812929 @default.
• W4293769218 cites W2059073891 @default.
• W4293769218 cites W2073140713 @default.
• W4293769218 cites W2073445330 @default.
• W4293769218 cites W2090075367 @default.
• W4293769218 cites W2096522979 @default.
• W4293769218 cites W2101010807 @default.
• W4293769218 cites W2112551996 @default.
• W4293769218 cites W2115634760 @default.
• W4293769218 cites W2123159591 @default.
• W4293769218 cites W2127072693 @default.
• W4293769218 cites W2127091950 @default.
• W4293769218 cites W2127684760 @default.
• W4293769218 cites W2127783517 @default.
• W4293769218 cites W2129588663 @default.
• W4293769218 cites W2154522026 @default.
• W4293769218 cites W2155286781 @default.
• W4293769218 cites W2163285329 @default.
• W4293769218 cites W2167315684 @default.
• W4293769218 cites W2168433590 @default.
• W4293769218 cites W2171314628 @default.
• W4293769218 cites W2314463797 @default.
• W4293769218 cites W2342116893 @default.
• W4293769218 cites W2414852797 @default.
• W4293769218 cites W2434017435 @default.
• W4293769218 cites W2560612434 @default.
• W4293769218 cites W2561035469 @default.
• W4293769218 cites W2582553117 @default.
• W4293769218 cites W2621775737 @default.
• W4293769218 cites W2622834178 @default.
• W4293769218 cites W2624657184 @default.
• W4293769218 cites W2767240870 @default.
• W4293769218 cites W2771013630 @default.
• W4293769218 cites W2791536572 @default.
• W4293769218 cites W2795379115 @default.
• W4293769218 cites W2896686759 @default.
• W4293769218 cites W2949271737 @default.
• W4293769218 cites W2949417290 @default.
• W4293769218 cites W2950395494 @default.
• W4293769218 cites W2963589105 @default.
• W4293769218 cites W2972520149 @default.
• W4293769218 cites W2991065352 @default.
• W4293769218 cites W3002931708 @default.
• W4293769218 cites W3025843910 @default.
• W4293769218 cites W3048837873 @default.
• W4293769218 cites W3081987135 @default.
• W4293769218 cites W3087677418 @default.
• W4293769218 cites W3091010978 @default.
• W4293769218 cites W3092660784 @default.
• W4293769218 cites W3094502714 @default.
• W4293769218 cites W3129189054 @default.
• W4293769218 cites W3134023604 @default.
• W4293769218 cites W3135053797 @default.
• W4293769218 cites W3135185578 @default.
• W4293769218 cites W3153439172 @default.
• W4293769218 cites W3170118250 @default.
• W4293769218 cites W3192744661 @default.
• W4293769218 cites W3194699305 @default.
• W4293769218 cites W3196379321 @default.
• W4293769218 cites W4220957049 @default.
• W4293769218 cites W4224228027 @default.
• W4293769218 cites W4226049367 @default.
• W4293769218 cites W4230914450 @default.
• W4293769218 cites W4280622077 @default.
• W4293769218 cites W4281874920 @default.
• W4293769218 cites W4285007783 @default.
• W4293769218 cites W4312595931 @default.
• W4293769218 cites W778206086 @default.
• W4293769218 doi "https://doi.org/10.1101/2022.08.26.505416" @default.
• W4293769218 hasPublicationYear "2022" @default.
• W4293769218 type Work @default.
• W4293769218 citedByCount "0" @default.
• W4293769218 crossrefType "posted-content" @default.
• W4293769218 hasAuthorship W4293769218A5026731530 @default.
• W4293769218 hasBestOaLocation W42937692181 @default.
• W4293769218 hasConcept C104317684 @default.
• W4293769218 hasConcept C105795698 @default.
• W4293769218 hasConcept C106934330 @default.
• W4293769218 hasConcept C144024400 @default.
• W4293769218 hasConcept C149923435 @default.
• W4293769218 hasConcept C161890455 @default.
• W4293769218 hasConcept C199360897 @default.

• next