Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293770130> ?p ?o ?g. }
- W4293770130 abstract "The expression of tissue-specific antigens (TSAs) in medullary thymic epithelial cells (mTECs) is believed to be responsible for the elimination of autoreactive T cells, a critical process in the maintenance of central immune tolerance. The transcription factor autoimmune regulator (Aire) and FEZ family zinc finger 2(Fezf2) play an essential role in driving the expression of TSAs in mTECs, while their deficiency in humans and mice causes a range of autoimmune manifestations, such as type 1 diabetes, Sjögren’s syndrome and rheumatoid arthritis. However, because of their regulatory mechanisms, the expression profile of TSAs and their relationship with special autoimmune diseases are still in dispute. In this review, we compare the roles of Aire and Fezf2 in regulating TSAs, with an emphasis on their molecular mechanisms in autoimmune diseases, which provides the foundation for devising improved diagnostic and therapeutic approaches for patients." @default.
- W4293770130 created "2022-08-31" @default.
- W4293770130 creator A5007793493 @default.
- W4293770130 creator A5020397032 @default.
- W4293770130 creator A5029335956 @default.
- W4293770130 creator A5067251286 @default.
- W4293770130 creator A5079491978 @default.
- W4293770130 date "2022-08-30" @default.
- W4293770130 modified "2023-10-16" @default.
- W4293770130 title "Aire and Fezf2, two regulators in medullary thymic epithelial cells, control autoimmune diseases by regulating TSAs: Partner or complementer?" @default.
- W4293770130 cites W1504375640 @default.
- W4293770130 cites W1558334142 @default.
- W4293770130 cites W1561092615 @default.
- W4293770130 cites W1561460904 @default.
- W4293770130 cites W1575239044 @default.
- W4293770130 cites W1592308846 @default.
- W4293770130 cites W1599916298 @default.
- W4293770130 cites W1844353938 @default.
- W4293770130 cites W1897084192 @default.
- W4293770130 cites W1948196874 @default.
- W4293770130 cites W1957982211 @default.
- W4293770130 cites W1977207493 @default.
- W4293770130 cites W1978668479 @default.
- W4293770130 cites W1982569530 @default.
- W4293770130 cites W1987482048 @default.
- W4293770130 cites W1989321724 @default.
- W4293770130 cites W1991475614 @default.
- W4293770130 cites W1999417890 @default.
- W4293770130 cites W2011254270 @default.
- W4293770130 cites W2013781601 @default.
- W4293770130 cites W2016375374 @default.
- W4293770130 cites W2016757852 @default.
- W4293770130 cites W2025929993 @default.
- W4293770130 cites W2027637975 @default.
- W4293770130 cites W2028222510 @default.
- W4293770130 cites W2033441651 @default.
- W4293770130 cites W2035188076 @default.
- W4293770130 cites W2035692793 @default.
- W4293770130 cites W2051479069 @default.
- W4293770130 cites W2064400534 @default.
- W4293770130 cites W2064437160 @default.
- W4293770130 cites W2064761981 @default.
- W4293770130 cites W2069545220 @default.
- W4293770130 cites W2075367960 @default.
- W4293770130 cites W2085567045 @default.
- W4293770130 cites W2090676538 @default.
- W4293770130 cites W2093069204 @default.
- W4293770130 cites W2094880341 @default.
- W4293770130 cites W2112066442 @default.
- W4293770130 cites W2114540703 @default.
- W4293770130 cites W2114944802 @default.
- W4293770130 cites W2115977441 @default.
- W4293770130 cites W2122722718 @default.
- W4293770130 cites W2128975028 @default.
- W4293770130 cites W2149026148 @default.
- W4293770130 cites W2154852694 @default.
- W4293770130 cites W2155964470 @default.
- W4293770130 cites W2157582906 @default.
- W4293770130 cites W2160127445 @default.
- W4293770130 cites W2162058869 @default.
- W4293770130 cites W2171080847 @default.
- W4293770130 cites W2274401507 @default.
- W4293770130 cites W2322270922 @default.
- W4293770130 cites W2338613830 @default.
- W4293770130 cites W2509583837 @default.
- W4293770130 cites W2527088177 @default.
- W4293770130 cites W2619872431 @default.
- W4293770130 cites W2735065502 @default.
- W4293770130 cites W2737785069 @default.
- W4293770130 cites W2753806050 @default.
- W4293770130 cites W2789003248 @default.
- W4293770130 cites W2791551292 @default.
- W4293770130 cites W2810217066 @default.
- W4293770130 cites W2892643460 @default.
- W4293770130 cites W2916020602 @default.
- W4293770130 cites W2945570498 @default.
- W4293770130 cites W3037980029 @default.
- W4293770130 cites W3119635134 @default.
- W4293770130 cites W4225562556 @default.
- W4293770130 cites W4229452915 @default.
- W4293770130 cites W4281716658 @default.
- W4293770130 doi "https://doi.org/10.3389/fimmu.2022.948259" @default.
- W4293770130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36110862" @default.
- W4293770130 hasPublicationYear "2022" @default.
- W4293770130 type Work @default.
- W4293770130 citedByCount "3" @default.
- W4293770130 countsByYear W42937701302022 @default.
- W4293770130 countsByYear W42937701302023 @default.
- W4293770130 crossrefType "journal-article" @default.
- W4293770130 hasAuthorship W4293770130A5007793493 @default.
- W4293770130 hasAuthorship W4293770130A5020397032 @default.
- W4293770130 hasAuthorship W4293770130A5029335956 @default.
- W4293770130 hasAuthorship W4293770130A5067251286 @default.
- W4293770130 hasAuthorship W4293770130A5079491978 @default.
- W4293770130 hasBestOaLocation W42937701301 @default.
- W4293770130 hasConcept C104317684 @default.
- W4293770130 hasConcept C134018914 @default.
- W4293770130 hasConcept C159654299 @default.
- W4293770130 hasConcept C203014093 @default.
- W4293770130 hasConcept C2776566471 @default.