FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293770158> ?p ?o ?g. }

• W4293770158 endingPage "3529" @default.
• W4293770158 startingPage "3529" @default.
• W4293770158 abstract "Mucoadhesive polymers have an essential role in drug localization and target-specific actions in oral delivery systems. The current work aims to develop and characterize a new mucoadhesive polysaccharide polymer (thiolated xanthan gum-TXG and S-Protected thiolated xanthan gum-STX) that was further utilized for the preparation of repaglinide mucoadhesive tablets. The thiolation of xanthan gum was carried out by ester formation through the reaction of the hydroxyl group of xanthan gum and the carboxyl group of thioglycolic acid. Synthesis of TXG was optimized using central composite design, and TXG prepared using 5.303 moles/L of TGA and 6.075 g/L of xanthan gum can accomplish the prerequisites of the optimized formulation. Consequently, TXG was further combined with aromatic 2-mercapto-nicotinic acid to synthesize STX. TXG and STX were further studied for Fourier-transform infrared spectroscopy, rheological investigations, and Ellman’s assay (to quantify the number of thiol/disulfide groups). A substantial rise in the viscosity of STX might be due to increased interactions of macromolecules liable for improving the mucosal adhesion strength of thiolated gum. STX was proven safe with the support of cytotoxic study data. Mucoadhesive formulations of repaglinide-containing STX showed the highest ex vivo mucoadhesion strength (12.78 g-RSX-1 and 17.57 g- RSX-2) and residence time (>16 h). The improved cross-linkage and cohesive nature of the matrix in the thiolated and S-protected thiolated formulations was responsible for the controlled release of repaglinide over 16 h. The pharmacokinetic study revealed the greater AUC (area under the curve) and long half-life with the RSX-2 formulation, confirming that formulations based on S-protected thiomers can be favorable drug systems for enhancing the bioavailability of low-solubility drugs." @default.
• W4293770158 created "2022-08-31" @default.
• W4293770158 creator A5014040048 @default.
• W4293770158 creator A5014649653 @default.
• W4293770158 creator A5023418233 @default.
• W4293770158 creator A5047076621 @default.
• W4293770158 creator A5051650957 @default.
• W4293770158 creator A5055467082 @default.
• W4293770158 creator A5057407322 @default.
• W4293770158 creator A5058926847 @default.
• W4293770158 creator A5063060227 @default.
• W4293770158 creator A5069803002 @default.
• W4293770158 creator A5081241625 @default.
• W4293770158 date "2022-08-28" @default.
• W4293770158 modified "2023-09-23" @default.
• W4293770158 title "Development of Novel S-Protective Thiolated-Based Mucoadhesive Tablets for Repaglinide: Pharmacokinetic Study" @default.
• W4293770158 cites W1979371226 @default.
• W4293770158 cites W1991397838 @default.
• W4293770158 cites W2012841500 @default.
• W4293770158 cites W2022707450 @default.
• W4293770158 cites W2023756774 @default.
• W4293770158 cites W2030821888 @default.
• W4293770158 cites W2037510773 @default.
• W4293770158 cites W2042414613 @default.
• W4293770158 cites W2065788763 @default.
• W4293770158 cites W2071059761 @default.
• W4293770158 cites W2079350482 @default.
• W4293770158 cites W2092043103 @default.
• W4293770158 cites W2092284116 @default.
• W4293770158 cites W2092919531 @default.
• W4293770158 cites W2103500142 @default.
• W4293770158 cites W2145223587 @default.
• W4293770158 cites W2149939512 @default.
• W4293770158 cites W2151536458 @default.
• W4293770158 cites W2158325944 @default.
• W4293770158 cites W2170591745 @default.
• W4293770158 cites W2191673434 @default.
• W4293770158 cites W2216174252 @default.
• W4293770158 cites W2329594443 @default.
• W4293770158 cites W2532093096 @default.
• W4293770158 cites W2570380080 @default.
• W4293770158 cites W2594668002 @default.
• W4293770158 cites W2594689717 @default.
• W4293770158 cites W2607125422 @default.
• W4293770158 cites W2611699806 @default.
• W4293770158 cites W2625669596 @default.
• W4293770158 cites W2738425619 @default.
• W4293770158 cites W2763299148 @default.
• W4293770158 cites W2789687015 @default.
• W4293770158 cites W2803548129 @default.
• W4293770158 cites W2886887355 @default.
• W4293770158 cites W2892585740 @default.
• W4293770158 cites W2907014796 @default.
• W4293770158 cites W2952353367 @default.
• W4293770158 cites W2964648755 @default.
• W4293770158 cites W2987087471 @default.
• W4293770158 cites W2987777199 @default.
• W4293770158 cites W3010036893 @default.
• W4293770158 cites W3015383652 @default.
• W4293770158 cites W3017796067 @default.
• W4293770158 cites W3028593088 @default.
• W4293770158 cites W3048437024 @default.
• W4293770158 cites W3127698784 @default.
• W4293770158 cites W3134932075 @default.
• W4293770158 cites W3164387035 @default.
• W4293770158 cites W3186811788 @default.
• W4293770158 cites W3215921600 @default.
• W4293770158 cites W396030138 @default.
• W4293770158 cites W4285585228 @default.
• W4293770158 doi "https://doi.org/10.3390/polym14173529" @default.
• W4293770158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36080604" @default.
• W4293770158 hasPublicationYear "2022" @default.
• W4293770158 type Work @default.
• W4293770158 citedByCount "6" @default.
• W4293770158 countsByYear W42937701582022 @default.
• W4293770158 countsByYear W42937701582023 @default.
• W4293770158 crossrefType "journal-article" @default.
• W4293770158 hasAuthorship W4293770158A5014040048 @default.
• W4293770158 hasAuthorship W4293770158A5014649653 @default.
• W4293770158 hasAuthorship W4293770158A5023418233 @default.
• W4293770158 hasAuthorship W4293770158A5047076621 @default.
• W4293770158 hasAuthorship W4293770158A5051650957 @default.
• W4293770158 hasAuthorship W4293770158A5055467082 @default.
• W4293770158 hasAuthorship W4293770158A5057407322 @default.
• W4293770158 hasAuthorship W4293770158A5058926847 @default.
• W4293770158 hasAuthorship W4293770158A5063060227 @default.
• W4293770158 hasAuthorship W4293770158A5069803002 @default.
• W4293770158 hasAuthorship W4293770158A5081241625 @default.
• W4293770158 hasBestOaLocation W42937701581 @default.
• W4293770158 hasConcept C134018914 @default.
• W4293770158 hasConcept C13965031 @default.
• W4293770158 hasConcept C159985019 @default.
• W4293770158 hasConcept C178790620 @default.
• W4293770158 hasConcept C185592680 @default.
• W4293770158 hasConcept C192562407 @default.
• W4293770158 hasConcept C200990466 @default.
• W4293770158 hasConcept C2776634624 @default.
• W4293770158 hasConcept C2777180221 @default.

• next