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• W4293776327 abstract "Background and Aims: Atrial fibrillation (AF) is the frequent arrhythmia found in clinical practice and. s associated with atrial structural changes that may have an inflammatory basis. Whereas the pleiotropic effect of statines, we aimed to assess the influence of high intensity statins on recurrence AF after successful cardioversion.Methods: 126 patients with non-valvular persistent AF (mean age 64.6 ± 9.7) where enrolled in this study and followed up during 24 weeks. .The echocardiography examination and 24-hour ambulatory Holter monitoring ECG were registered in each patient. Blood samples were tested on the serum levels of hs-CRP and IL-6. All patients were divided in to two groups. The first group was treated by Atorvastatin 40mg or Rosuvastatine 10mg; the second group has administrated placebo (P). Prophylactic drug therapy with Amiodarone (200-300 mg daily) was administered to all patients.Results: The obtained results have shown that the basis data of hs-CRP and of IL-6 levels in patients with persistent AF were increased (0.82±0.32 mg/dL and 22±11 pg/ml accordingly). After 24 weeks treatment in first group these indices were significantly reduced (0.48±0.11 mg/dL, p < 0.001 and 12.1±4.9 pg/ml, p<0.001 accordingly vs. second group with P; 0.76± 0.32 mg/dL, 18.1± 3.9 pg/ml,). The follow-up during 24 weeks has shown that primary end-point in first group reduces AF recurrence to 4.6% compared 19% in the placebo group.Conclusions: High intensity statins have been effective in the prevention of AF recurrence after successful cardioversion. Background and Aims: Atrial fibrillation (AF) is the frequent arrhythmia found in clinical practice and. s associated with atrial structural changes that may have an inflammatory basis. Whereas the pleiotropic effect of statines, we aimed to assess the influence of high intensity statins on recurrence AF after successful cardioversion. Methods: 126 patients with non-valvular persistent AF (mean age 64.6 ± 9.7) where enrolled in this study and followed up during 24 weeks. .The echocardiography examination and 24-hour ambulatory Holter monitoring ECG were registered in each patient. Blood samples were tested on the serum levels of hs-CRP and IL-6. All patients were divided in to two groups. The first group was treated by Atorvastatin 40mg or Rosuvastatine 10mg; the second group has administrated placebo (P). Prophylactic drug therapy with Amiodarone (200-300 mg daily) was administered to all patients. Results: The obtained results have shown that the basis data of hs-CRP and of IL-6 levels in patients with persistent AF were increased (0.82±0.32 mg/dL and 22±11 pg/ml accordingly). After 24 weeks treatment in first group these indices were significantly reduced (0.48±0.11 mg/dL, p < 0.001 and 12.1±4.9 pg/ml, p<0.001 accordingly vs. second group with P; 0.76± 0.32 mg/dL, 18.1± 3.9 pg/ml,). The follow-up during 24 weeks has shown that primary end-point in first group reduces AF recurrence to 4.6% compared 19% in the placebo group. Conclusions: High intensity statins have been effective in the prevention of AF recurrence after successful cardioversion." @default.
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• W4293776327 date "2022-08-01" @default.
• W4293776327 modified "2023-09-25" @default.
• W4293776327 title "The impact of high intensity statins long treatment for recurrence of atrial fibrillation after successful cardioversion" @default.
• W4293776327 doi "https://doi.org/10.1016/j.atherosclerosis.2022.06.883" @default.
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