Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293776340> ?p ?o ?g. }
- W4293776340 abstract "Abstract The site‐selective introduction of the difluoromethylene group into organic molecules has important applications in producing pharmaceuticals and agrochemicals. However, the general and efficient methods that can construct both C(sp 2 )−CF 2 R and C(sp 3 )−CF 2 R bonds remain challenging. Here, we disclose a new type of practical and bench‐stable difluoroalkylating reagent 3,3‐difluoroallyl sulfonium salt (DFAS) that can be practically prepared from inexpensive and bulk chemical feedstock 3,3,3‐trifluoropropene. This reagent allows highly regioselective gem ‐difluoroallylation of various organozinc reagents, including aryl, primary, secondary, and tertiary alkyl zinc reagents, via copper catalysis under mild reaction conditions with high efficiency. The reaction can also be extended to a series of substituted DFASs. Application of the approach leads to the short synthesis of complex analogs, showing the prospect of DFASs in medicinal chemistry." @default.
- W4293776340 created "2022-08-31" @default.
- W4293776340 creator A5014946456 @default.
- W4293776340 creator A5023573232 @default.
- W4293776340 creator A5033525635 @default.
- W4293776340 creator A5049812247 @default.
- W4293776340 creator A5052949479 @default.
- W4293776340 date "2022-09-12" @default.
- W4293776340 modified "2023-10-18" @default.
- W4293776340 title "3,3‐Difluoroallyl Sulfonium Salts: Practical and Bench‐Stable Reagents for Highly Regioselective <i>gem</i>‐Difluoroallylations" @default.
- W4293776340 cites W1980545483 @default.
- W4293776340 cites W1993396528 @default.
- W4293776340 cites W1994685053 @default.
- W4293776340 cites W2001086298 @default.
- W4293776340 cites W2009008810 @default.
- W4293776340 cites W2021208456 @default.
- W4293776340 cites W2030044757 @default.
- W4293776340 cites W2031566166 @default.
- W4293776340 cites W2033043158 @default.
- W4293776340 cites W2041838304 @default.
- W4293776340 cites W2064285218 @default.
- W4293776340 cites W2068912668 @default.
- W4293776340 cites W2074562411 @default.
- W4293776340 cites W2080380829 @default.
- W4293776340 cites W2097269537 @default.
- W4293776340 cites W2103458395 @default.
- W4293776340 cites W2135165187 @default.
- W4293776340 cites W2136864332 @default.
- W4293776340 cites W2141471401 @default.
- W4293776340 cites W2144869962 @default.
- W4293776340 cites W2145905191 @default.
- W4293776340 cites W2179043943 @default.
- W4293776340 cites W2316766720 @default.
- W4293776340 cites W2317369589 @default.
- W4293776340 cites W2318890568 @default.
- W4293776340 cites W2333129245 @default.
- W4293776340 cites W2334452370 @default.
- W4293776340 cites W2334721406 @default.
- W4293776340 cites W2422726141 @default.
- W4293776340 cites W2463830137 @default.
- W4293776340 cites W2514133714 @default.
- W4293776340 cites W2754868188 @default.
- W4293776340 cites W2785609333 @default.
- W4293776340 cites W2888745810 @default.
- W4293776340 cites W2896643225 @default.
- W4293776340 cites W2914850818 @default.
- W4293776340 cites W2950060685 @default.
- W4293776340 cites W2951586314 @default.
- W4293776340 cites W2952241351 @default.
- W4293776340 cites W2952917342 @default.
- W4293776340 cites W2956147480 @default.
- W4293776340 cites W2965256032 @default.
- W4293776340 cites W2996397106 @default.
- W4293776340 cites W3019266968 @default.
- W4293776340 cites W3035147027 @default.
- W4293776340 cites W3057402443 @default.
- W4293776340 cites W3123738238 @default.
- W4293776340 cites W3164117193 @default.
- W4293776340 cites W3199405481 @default.
- W4293776340 cites W4211185850 @default.
- W4293776340 cites W4214899275 @default.
- W4293776340 cites W4239740227 @default.
- W4293776340 cites W4253291214 @default.
- W4293776340 cites W4284994407 @default.
- W4293776340 cites W74164514 @default.
- W4293776340 doi "https://doi.org/10.1002/anie.202210103" @default.
- W4293776340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36042013" @default.
- W4293776340 hasPublicationYear "2022" @default.
- W4293776340 type Work @default.
- W4293776340 citedByCount "15" @default.
- W4293776340 countsByYear W42937763402022 @default.
- W4293776340 countsByYear W42937763402023 @default.
- W4293776340 crossrefType "journal-article" @default.
- W4293776340 hasAuthorship W4293776340A5014946456 @default.
- W4293776340 hasAuthorship W4293776340A5023573232 @default.
- W4293776340 hasAuthorship W4293776340A5033525635 @default.
- W4293776340 hasAuthorship W4293776340A5049812247 @default.
- W4293776340 hasAuthorship W4293776340A5052949479 @default.
- W4293776340 hasConcept C161790260 @default.
- W4293776340 hasConcept C178790620 @default.
- W4293776340 hasConcept C185592680 @default.
- W4293776340 hasConcept C21951064 @default.
- W4293776340 hasConcept C2776371256 @default.
- W4293776340 hasConcept C2777040163 @default.
- W4293776340 hasConcept C2780263894 @default.
- W4293776340 hasConcept C2781076698 @default.
- W4293776340 hasConcept C40875361 @default.
- W4293776340 hasConcept C59759590 @default.
- W4293776340 hasConceptScore W4293776340C161790260 @default.
- W4293776340 hasConceptScore W4293776340C178790620 @default.
- W4293776340 hasConceptScore W4293776340C185592680 @default.
- W4293776340 hasConceptScore W4293776340C21951064 @default.
- W4293776340 hasConceptScore W4293776340C2776371256 @default.
- W4293776340 hasConceptScore W4293776340C2777040163 @default.
- W4293776340 hasConceptScore W4293776340C2780263894 @default.
- W4293776340 hasConceptScore W4293776340C2781076698 @default.
- W4293776340 hasConceptScore W4293776340C40875361 @default.
- W4293776340 hasConceptScore W4293776340C59759590 @default.
- W4293776340 hasFunder F4320321001 @default.
- W4293776340 hasFunder F4320335777 @default.