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• W4293776388 abstract "Background and Aims : Three mechanisms are responsible for the development of restenosis: elastic recoil, intimal hyperplasia and late vascular constriction, all grouped under the catch phrase “negative remodeling”. Neointimal hyperplasia is usually defined in an artery as thickening of the intimal layer after an injury such as balloon angioplasty methods. The aim of this study was to evaluate the effect of combined ultrasound sonodynamic therapy and catheter- based 186Re-mediated beta radiation (β-) brachytherapy on restenosis reduction after balloon angioplasty.Methods: Briefly, golden Syrian hamsters were submitted to common carotid artery advanced atherosclerotic occlusion by primary perivascular Co2 laser-mediated far-infrared injury followed by a 2% cholesterol-rich diet for six weeks. Histopathology results showed the formation of a thick- cap fibroatheromatic plaque, resulted to occlusion in all of the hamsters’ arteries. Then treatment group (n=10) underwent B-mode ultrasound- guided balloon angioplasty followed by sonosensitizer hematoporphyrin- loaded PESDA (Perfluorocarbon Exposed Sonicated Dextrose Albumin) microbubbles (100ml/kg, 2–5×105 bubbles/ml)- mediated pulsed low level focused ultrasound (F=450 KHz, I=5.5 W/cm2, PD=120 ms) sonodynamic therapy and catheter- based β- brachytherapy (186Re −, 28 Gy).Results: from ultrasonography and histopathology showed a significant reduction in the mean value for macrophages and hyperplastic vascular smooth muscle cells density after balloon angioplasty in the treated group compared with the other groups (p<0.05).Conclusions: Enhanced anti-inflammatory effect of hematoporphyrin- mediated sonodynamic therapy, induced by collapsed microbubbles- mediated enhanced ultrasound sonoporation therapy accompanied by apoptotic effect of rhenium-186- mediated β- brachytherapy, can cause to reduce the neointima hyperplasia. Background and Aims : Three mechanisms are responsible for the development of restenosis: elastic recoil, intimal hyperplasia and late vascular constriction, all grouped under the catch phrase “negative remodeling”. Neointimal hyperplasia is usually defined in an artery as thickening of the intimal layer after an injury such as balloon angioplasty methods. The aim of this study was to evaluate the effect of combined ultrasound sonodynamic therapy and catheter- based 186Re-mediated beta radiation (β-) brachytherapy on restenosis reduction after balloon angioplasty. Methods: Briefly, golden Syrian hamsters were submitted to common carotid artery advanced atherosclerotic occlusion by primary perivascular Co2 laser-mediated far-infrared injury followed by a 2% cholesterol-rich diet for six weeks. Histopathology results showed the formation of a thick- cap fibroatheromatic plaque, resulted to occlusion in all of the hamsters’ arteries. Then treatment group (n=10) underwent B-mode ultrasound- guided balloon angioplasty followed by sonosensitizer hematoporphyrin- loaded PESDA (Perfluorocarbon Exposed Sonicated Dextrose Albumin) microbubbles (100ml/kg, 2–5×105 bubbles/ml)- mediated pulsed low level focused ultrasound (F=450 KHz, I=5.5 W/cm2, PD=120 ms) sonodynamic therapy and catheter- based β- brachytherapy (186Re −, 28 Gy). Results: from ultrasonography and histopathology showed a significant reduction in the mean value for macrophages and hyperplastic vascular smooth muscle cells density after balloon angioplasty in the treated group compared with the other groups (p<0.05). Conclusions: Enhanced anti-inflammatory effect of hematoporphyrin- mediated sonodynamic therapy, induced by collapsed microbubbles- mediated enhanced ultrasound sonoporation therapy accompanied by apoptotic effect of rhenium-186- mediated β- brachytherapy, can cause to reduce the neointima hyperplasia." @default.
• W4293776388 created "2022-08-31" @default.
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• W4293776388 date "2022-08-01" @default.
• W4293776388 modified "2023-09-27" @default.
• W4293776388 title "Hematoporphyrin- mediated focused ultrasound sonodynamic therapy combined with catheter- based rhenium-186 brachytherapy after B- mode ultrasound- guided balloon angioplasty of occluded artery" @default.
• W4293776388 doi "https://doi.org/10.1016/j.atherosclerosis.2022.06.929" @default.
• W4293776388 hasPublicationYear "2022" @default.
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