FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293777609> ?p ?o ?g. }

• W4293777609 endingPage "191" @default.
• W4293777609 startingPage "184" @default.
• W4293777609 abstract "Polycystic ovary syndrome (PCOS) is a common type of endocrinopathy in women which is accompanied by androgens elevation, insulin resistance, and metabolic dysfunction. Eugenol is a phenolic component of clove oil that has an antioxidant, anti-inflammatory, and anti-diabetic activity. The present study aimed to evaluate the therapeutic effects of eugenol on the PCOS models of rats.In this experimental study, thirty adults female Wistar rats weighing between 180 and 200 g were used. Estradiol valerate-induced PCOS rats (4 mg/rat) were treated with eugenol (12 and 24 mg/kg) for 28 days. The effects of eugenol were studied on levels of glucose, lipid profile, liver enzymes, reproductive hormones, oxidative stress, and the expression of cyclooxygenase-2 (Cox-2) and peroxisome proliferator-activated receptor alpha (Ppar-α) genes, using biochemical analysis of blood and histopathological evaluation of ovaries.<br />Results: Estradiol valerate-induced PCOS resulted in the formation of cystic follicles in the ovaries, hyperinsulinemia, hyperglycemia, hyperlipidemia, hyperandrogenism, and anovulation. It altered the Cox-2 and Ppar-α gene expression and increased oxidative stress and activities of liver enzymes. Eugenol treatment improved the PCOS-associated endocrine and metabolic disorder and histopathological alterations, mostly through antioxidant, anti-diabetic, anti hyperlipidemic, and anti-androgenic properties. It showed beneficial effects on serum glucose, serum insulin, fat profile, reproductive hormones, liver activity, oxidative stress, expression of Cox-2 and Ppar-α genes, as well as restoration of normal ovulation in the PCOS animals.<br />Conclusion: Eugenol could represent a promising natural product to prevent PCOS or reduce its symptoms." @default.
• W4293777609 created "2022-08-31" @default.
• W4293777609 creator A5014617389 @default.
• W4293777609 creator A5074323973 @default.
• W4293777609 creator A5076218289 @default.
• W4293777609 creator A5088492195 @default.
• W4293777609 date "2022-08-21" @default.
• W4293777609 modified "2023-09-23" @default.
• W4293777609 title "Therapeutic Effects of Eugenol in Polycystic Ovarian Rats Induced by Estradiol Valerate: A Histopathological and A Biochemical Study." @default.
• W4293777609 cites W1553924890 @default.
• W4293777609 cites W1990719351 @default.
• W4293777609 cites W2028840448 @default.
• W4293777609 cites W2035182977 @default.
• W4293777609 cites W2035907631 @default.
• W4293777609 cites W2045175945 @default.
• W4293777609 cites W2063485400 @default.
• W4293777609 cites W2066915043 @default.
• W4293777609 cites W2087004090 @default.
• W4293777609 cites W2088880601 @default.
• W4293777609 cites W2103242587 @default.
• W4293777609 cites W2113550031 @default.
• W4293777609 cites W2116245445 @default.
• W4293777609 cites W2120503329 @default.
• W4293777609 cites W2124509857 @default.
• W4293777609 cites W2124728669 @default.
• W4293777609 cites W2132858798 @default.
• W4293777609 cites W2138818297 @default.
• W4293777609 cites W2260005777 @default.
• W4293777609 cites W2790405523 @default.
• W4293777609 cites W2793887346 @default.
• W4293777609 cites W2809201572 @default.
• W4293777609 cites W2897567577 @default.
• W4293777609 cites W2901508016 @default.
• W4293777609 cites W2904438693 @default.
• W4293777609 cites W2945427430 @default.
• W4293777609 cites W2991620808 @default.
• W4293777609 cites W3114624102 @default.
• W4293777609 cites W3126243044 @default.
• W4293777609 cites W4239622936 @default.
• W4293777609 cites W2990845633 @default.
• W4293777609 doi "https://doi.org/10.22074/ijfs.2021.537724.1176" @default.
• W4293777609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36029055" @default.
• W4293777609 hasPublicationYear "2022" @default.
• W4293777609 type Work @default.
• W4293777609 citedByCount "4" @default.
• W4293777609 countsByYear W42937776092022 @default.
• W4293777609 countsByYear W42937776092023 @default.
• W4293777609 crossrefType "journal-article" @default.
• W4293777609 hasAuthorship W4293777609A5014617389 @default.
• W4293777609 hasAuthorship W4293777609A5074323973 @default.
• W4293777609 hasAuthorship W4293777609A5076218289 @default.
• W4293777609 hasAuthorship W4293777609A5088492195 @default.
• W4293777609 hasConcept C126322002 @default.
• W4293777609 hasConcept C134018914 @default.
• W4293777609 hasConcept C178790620 @default.
• W4293777609 hasConcept C185592680 @default.
• W4293777609 hasConcept C2776151105 @default.
• W4293777609 hasConcept C2777391703 @default.
• W4293777609 hasConcept C2778001906 @default.
• W4293777609 hasConcept C2779306644 @default.
• W4293777609 hasConcept C2780186808 @default.
• W4293777609 hasConcept C2780470866 @default.
• W4293777609 hasConcept C2780853582 @default.
• W4293777609 hasConcept C2780988686 @default.
• W4293777609 hasConcept C3018442814 @default.
• W4293777609 hasConcept C71315377 @default.
• W4293777609 hasConcept C71924100 @default.
• W4293777609 hasConceptScore W4293777609C126322002 @default.
• W4293777609 hasConceptScore W4293777609C134018914 @default.
• W4293777609 hasConceptScore W4293777609C178790620 @default.
• W4293777609 hasConceptScore W4293777609C185592680 @default.
• W4293777609 hasConceptScore W4293777609C2776151105 @default.
• W4293777609 hasConceptScore W4293777609C2777391703 @default.
• W4293777609 hasConceptScore W4293777609C2778001906 @default.
• W4293777609 hasConceptScore W4293777609C2779306644 @default.
• W4293777609 hasConceptScore W4293777609C2780186808 @default.
• W4293777609 hasConceptScore W4293777609C2780470866 @default.
• W4293777609 hasConceptScore W4293777609C2780853582 @default.
• W4293777609 hasConceptScore W4293777609C2780988686 @default.
• W4293777609 hasConceptScore W4293777609C3018442814 @default.
• W4293777609 hasConceptScore W4293777609C71315377 @default.
• W4293777609 hasConceptScore W4293777609C71924100 @default.
• W4293777609 hasIssue "3" @default.
• W4293777609 hasLocation W42937776091 @default.
• W4293777609 hasOpenAccess W4293777609 @default.
• W4293777609 hasPrimaryLocation W42937776091 @default.
• W4293777609 hasRelatedWork W1999399744 @default.
• W4293777609 hasRelatedWork W2012178256 @default.
• W4293777609 hasRelatedWork W2022955668 @default.
• W4293777609 hasRelatedWork W2053450620 @default.
• W4293777609 hasRelatedWork W2055600249 @default.
• W4293777609 hasRelatedWork W2216680543 @default.
• W4293777609 hasRelatedWork W2403633279 @default.
• W4293777609 hasRelatedWork W4240163782 @default.
• W4293777609 hasRelatedWork W4291016463 @default.
• W4293777609 hasRelatedWork W2562632102 @default.
• W4293777609 hasVolume "16" @default.
• W4293777609 isParatext "false" @default.

• next