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- W4293777691 endingPage "8878" @default.
- W4293777691 startingPage "8878" @default.
- W4293777691 abstract "Metastatic triple-negative breast cancer (mTNBC), a highly aggressive and malignant tumor, currently lacks an effective treatment. There has been some progress in the treatment of mTNBC with programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1) immunotherapy in recent years. The combination of PD-1/PD-L1 inhibitors with other therapies is a noteworthy treatment strategy. Immunotherapy in combination with chemotherapy or small-molecule inhibitors still faces many challenges. Additionally, there are some new immunotherapy targets in development. We aimed to further evaluate the effectiveness and usefulness of immunotherapy for treating mTNBC and to propose new immunotherapy strategies. This review explains the rationale and results of existing clinical trials evaluating PD-1/PD-L1 inhibitors alone or in combination for the treatment of mTNBC. For patients with aggressive tumors and poor health, PD-1/PD-L1 inhibitors, either alone or in combination with other modalities, have proven to be effective. However, more research is needed to explore more effective immunotherapy regimens that will lead to new breakthroughs in the treatment of mTNBC." @default.
- W4293777691 created "2022-08-31" @default.
- W4293777691 creator A5003053192 @default.
- W4293777691 creator A5032748496 @default.
- W4293777691 creator A5086362198 @default.
- W4293777691 creator A5089530056 @default.
- W4293777691 date "2022-08-10" @default.
- W4293777691 modified "2023-09-26" @default.
- W4293777691 title "Rationale and Clinical Research Progress on PD-1/PD-L1-Based Immunotherapy for Metastatic Triple-Negative Breast Cancer" @default.
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- W4293777691 doi "https://doi.org/10.3390/ijms23168878" @default.
- W4293777691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36012144" @default.
- W4293777691 hasPublicationYear "2022" @default.