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- W4293778077 abstract "Objective: To analyze the clinical features, treatment and prognosis of solitary rectal ulcer syndrome (SRUS) in children. Methods: The clinical data of 7 children who were diagnosed with SRUS in Department of Gastroenterology in Guangzhou Women and Children' Medical Center from January 2019 to December 2021 were retrospectively analyzed. The clinical data including general demographics, clinical presentations, endoscopic and histologic features, treatment and outcome were extracted from hospital medical records. Results: The 7 patients were all males, and the age of onset was 6-12 years. The course before diagnosis was 2-36 months. The most common symptom was rectal bleeding (6 cases) and most common findings at initial colonoscopy were ulcer in 3 cases and protuberance in 4 cases, both located only in rectum. The intestinal histopathology of 5 cases showed characteristic fibromuscular obliteration of lamina propria. Five children were treated with mesalamine granules or suppositories, and 2 cases underwent local excision. The follow-up lasted for 5-24 months and found symptoms relieved in 5 cases, improved in 1 case, and no remission in 1 case. Colonoscopy after the treatment was performed in 5 children, among whom 2 cases achieved mucosal healing. Conclusions: SRUS in children is mainly presented with rectal bleeding, and has characteristic histological change of ulcer and protuberance in endoscopy. Pathology is crucial for diagnosis and differential diagnosis. Both the medical and surgical treatment are effective for SRUS.目的： 分析孤立性直肠溃疡综合征（SRUS）的临床特点及治疗转归。 方法： 回顾性收集2019年1月至2021年12月在广州市妇女儿童医疗中心消化科被诊断为SRUS 的7例患儿的临床资料，包括一般资料、临床表现、消化道内镜、病理表现及治疗、转归。 结果： 7例SRUS患儿均为男性，发病年龄为6~12岁，诊断时病程2~36个月。最常见的症状为血便（6例）。内镜下病变仅累及于直肠，包括溃疡3例、隆起样改变4例。5例患儿肠组织病理可见到黏膜固有层纤维肌性闭塞的特征性改变。5例行内科治疗（美沙拉嗪颗粒或美沙拉嗪栓），2例外科手术治疗。随访 5~24个月，5例患儿症状维持缓解，1例好转，1例无效。5例患儿复查内镜，其中2例达到黏膜愈合。 结论： 直肠出血是儿童SRUS最常见的临床表现，直肠溃疡和隆起病变均是内镜下的特征表现。病理对诊断及鉴别诊断十分重要。内外科治疗对SRUS都有效。." @default.
- W4293778077 created "2022-08-31" @default.
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- W4293778077 date "2022-09-02" @default.
- W4293778077 modified "2023-09-30" @default.
- W4293778077 title "[Analysis of solitary rectal ulcer syndrome in 7 children]." @default.
- W4293778077 doi "https://doi.org/10.3760/cma.j.cn112140-20220221-00137" @default.
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