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- W4293778343 endingPage "9378" @default.
- W4293778343 startingPage "9378" @default.
- W4293778343 abstract "Patients diagnosed with metastatic uveal melanoma (MUM) have a poor survival prognosis. Unfortunately for this rare disease, there is no known cure and suitable therapeutic options are limited. HDAC6 inhibitors (HDAC6i) are currently in clinical trials for other cancers and show potential beneficial effects against tumor cell survival in vitro and in vivo. In MUM cells, HDAC6i show an anti-proliferative effect in vitro and in preclinical xenograft models. The use of HDAC6 inhibitors as a treatment option for MUM should be explored further. Therefore, this review discusses (1) what is known about HDAC6i in MUM and (2) whether HDAC6 inhibitors offer a potential therapeutic option for MUM." @default.
- W4293778343 created "2022-08-31" @default.
- W4293778343 creator A5021655948 @default.
- W4293778343 creator A5043561217 @default.
- W4293778343 creator A5074584694 @default.
- W4293778343 date "2022-08-19" @default.
- W4293778343 modified "2023-10-05" @default.
- W4293778343 title "Evaluation of the Therapeutic Potential of Histone Deacetylase 6 Inhibitors for Primary and Metastatic Uveal Melanoma" @default.
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