Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293778957> ?p ?o ?g. }
- W4293778957 endingPage "896" @default.
- W4293778957 startingPage "896" @default.
- W4293778957 abstract "Genetic recombination is used as a tool for modifying the composition of poxvirus genomes in both discovery and applied research. This review documents the history behind the development of these tools as well as what has been learned about the processes that catalyze virus recombination and the links between it and DNA replication and repair. The study of poxvirus recombination extends back to the 1930s with the discovery that one virus can reactivate another by a process later shown to generate recombinants. In the years that followed it was shown that recombinants can be produced in virus-by-virus crosses within a genus (e.g., variola-by-rabbitpox) and efforts were made to produce recombination-based genetic maps with modest success. The marker rescue mapping method proved more useful and led to methods for making genetically engineered viruses. Many further insights into the mechanism of recombination have been provided by transfection studies which have shown that this is a high-frequency process associated with hybrid DNA formation and inextricably linked to replication. The links reflect the fact that poxvirus DNA polymerases, specifically the vaccinia virus E9 enzyme, can catalyze strand transfer in in vivo and in vitro reactions dependent on the 3'-to-5' proofreading exonuclease and enhanced by the I3 replicative single-strand DNA binding protein. These reactions have shaped the composition of virus genomes and are modulated by constraints imposed on virus-virus interactions by viral replication in cytoplasmic factories. As recombination reactions are used for replication fork assembly and repair in many biological systems, further study of these reactions may provide new insights into still poorly understood features of poxvirus DNA replication." @default.
- W4293778957 created "2022-08-31" @default.
- W4293778957 creator A5020926082 @default.
- W4293778957 date "2022-08-09" @default.
- W4293778957 modified "2023-09-30" @default.
- W4293778957 title "Poxvirus Recombination" @default.
- W4293778957 cites W127236614 @default.
- W4293778957 cites W1484966744 @default.
- W4293778957 cites W1486346025 @default.
- W4293778957 cites W1492738820 @default.
- W4293778957 cites W1495643870 @default.
- W4293778957 cites W1495643895 @default.
- W4293778957 cites W1507235729 @default.
- W4293778957 cites W1515844392 @default.
- W4293778957 cites W1518867859 @default.
- W4293778957 cites W1522976219 @default.
- W4293778957 cites W1527293429 @default.
- W4293778957 cites W1530517085 @default.
- W4293778957 cites W1536941941 @default.
- W4293778957 cites W1539685331 @default.
- W4293778957 cites W1542697557 @default.
- W4293778957 cites W1544370487 @default.
- W4293778957 cites W1557849078 @default.
- W4293778957 cites W1569141376 @default.
- W4293778957 cites W1570361288 @default.
- W4293778957 cites W1586424768 @default.
- W4293778957 cites W1601133215 @default.
- W4293778957 cites W1601323152 @default.
- W4293778957 cites W1672229312 @default.
- W4293778957 cites W1709440728 @default.
- W4293778957 cites W1763001481 @default.
- W4293778957 cites W1766300918 @default.
- W4293778957 cites W1784001828 @default.
- W4293778957 cites W1795796006 @default.
- W4293778957 cites W1799651002 @default.
- W4293778957 cites W1846625983 @default.
- W4293778957 cites W1860935351 @default.
- W4293778957 cites W1864246467 @default.
- W4293778957 cites W1885654548 @default.
- W4293778957 cites W1936773733 @default.
- W4293778957 cites W1965372133 @default.
- W4293778957 cites W1966084869 @default.
- W4293778957 cites W1970474318 @default.
- W4293778957 cites W1974354259 @default.
- W4293778957 cites W1975384668 @default.
- W4293778957 cites W1977297067 @default.
- W4293778957 cites W1977516369 @default.
- W4293778957 cites W1977642996 @default.
- W4293778957 cites W1980515432 @default.
- W4293778957 cites W1982397291 @default.
- W4293778957 cites W1985353141 @default.
- W4293778957 cites W1985497347 @default.
- W4293778957 cites W1986090612 @default.
- W4293778957 cites W1986154593 @default.
- W4293778957 cites W1987056279 @default.
- W4293778957 cites W1987086578 @default.
- W4293778957 cites W1987788635 @default.
- W4293778957 cites W1989072352 @default.
- W4293778957 cites W1989344601 @default.
- W4293778957 cites W1989718073 @default.
- W4293778957 cites W1989775764 @default.
- W4293778957 cites W1991670881 @default.
- W4293778957 cites W1991720374 @default.
- W4293778957 cites W1992743225 @default.
- W4293778957 cites W1996299849 @default.
- W4293778957 cites W1996386324 @default.
- W4293778957 cites W1998645835 @default.
- W4293778957 cites W1998696660 @default.
- W4293778957 cites W2000402692 @default.
- W4293778957 cites W2002148350 @default.
- W4293778957 cites W2004592640 @default.
- W4293778957 cites W2005348559 @default.
- W4293778957 cites W2006967490 @default.
- W4293778957 cites W2007818370 @default.
- W4293778957 cites W2009840119 @default.
- W4293778957 cites W2010014458 @default.
- W4293778957 cites W2012419031 @default.
- W4293778957 cites W2013970428 @default.
- W4293778957 cites W2014845817 @default.
- W4293778957 cites W2016038582 @default.
- W4293778957 cites W2016728250 @default.
- W4293778957 cites W2017297993 @default.
- W4293778957 cites W2018748593 @default.
- W4293778957 cites W2019715916 @default.
- W4293778957 cites W2024852465 @default.
- W4293778957 cites W2028101507 @default.
- W4293778957 cites W2028814295 @default.
- W4293778957 cites W2028889980 @default.
- W4293778957 cites W2029017181 @default.
- W4293778957 cites W2034252391 @default.
- W4293778957 cites W2034922922 @default.
- W4293778957 cites W2038166412 @default.
- W4293778957 cites W2038439158 @default.
- W4293778957 cites W2042811763 @default.
- W4293778957 cites W2043889392 @default.
- W4293778957 cites W2043950542 @default.
- W4293778957 cites W2045563677 @default.
- W4293778957 cites W2046583367 @default.