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- W4293789078 abstract "Abstract Background: Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administrated Combined Metabolic Activators (CMA) to the AD rat model and observed that administration of CMA activated the mitochondrial functions and eventually improved the AD-associated histological parameters in the animals. CMA consists of NAD+ and glutathione precursors and includes L-serine, nicotinamide riboside, N-acetyl-L-cysteine, and L-carnitine tartrate. Methods: Here, we designed a randomised, double-blinded, placebo-controlled phase-II trial and studied the effect of CMA administration on the global metabolism of AD patients. The primary endpoint was on the difference in cognitive and daily living activity scores between the placebo and the treatment arms. The secondary aim of this study was to evaluate the safety and tolerability of CMA. We also performed a comprehensive human plasma metabolome and proteome analysis. Results: Based on our analysis, we showed a significant decrease of ADAS-Cog scores on Day 84 vs Day 0 (p=0.00001, 29% improvement) in the CMA group. Moreover, there was a significant enhancement (p=0.0073) in ADAS-Cog scores between CMA and placebo groups in patients with higher ADAS-Cog scores. Improved cognitive functions were endorsed with relevant hippocampal volumes and cortical thickness alterations. Moreover, the plasma levels of proteins and metabolites associated with NAD+ and glutathione metabolism are significantly improved after treatment. Conclusion: In conclusion, our results show that treating AD patients with CMA leads to enhanced cognitive functions associated with the improved metabolome, proteome and structural neuroimaging parameters, suggesting a role for such a therapeutic regimen in treating patients, especially with severe AD. Trial registration: ClinicalTrials.gov NCT04044131 Registered 17 July 2019, https://clinicaltrials.gov/ct2/show/NCT04044131" @default.
- W4293789078 created "2022-08-31" @default.
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- W4293789078 date "2022-08-31" @default.
- W4293789078 modified "2023-10-16" @default.
- W4293789078 title "Combined Metabolic Activators Improves Cognitive Functions in Alzheimer’s Disease Patients" @default.
- W4293789078 cites W1520589624 @default.
- W4293789078 cites W1552673037 @default.
- W4293789078 cites W1571431689 @default.
- W4293789078 cites W1607173640 @default.
- W4293789078 cites W1703528746 @default.
- W4293789078 cites W1720001930 @default.
- W4293789078 cites W1854850313 @default.
- W4293789078 cites W1964595024 @default.
- W4293789078 cites W1965336960 @default.
- W4293789078 cites W1975956286 @default.
- W4293789078 cites W1980698168 @default.
- W4293789078 cites W1981190087 @default.
- W4293789078 cites W1987188991 @default.
- W4293789078 cites W1988065251 @default.
- W4293789078 cites W1990293508 @default.
- W4293789078 cites W1998229934 @default.
- W4293789078 cites W2004293194 @default.
- W4293789078 cites W2007150982 @default.
- W4293789078 cites W2010259789 @default.
- W4293789078 cites W2010651946 @default.
- W4293789078 cites W2013589717 @default.
- W4293789078 cites W2013898280 @default.
- W4293789078 cites W2016358822 @default.
- W4293789078 cites W2029377385 @default.
- W4293789078 cites W2036288989 @default.
- W4293789078 cites W2038034523 @default.
- W4293789078 cites W2041184642 @default.
- W4293789078 cites W2046826354 @default.
- W4293789078 cites W2052588755 @default.
- W4293789078 cites W2058124777 @default.
- W4293789078 cites W2062614652 @default.
- W4293789078 cites W2063530717 @default.
- W4293789078 cites W2066582680 @default.
- W4293789078 cites W2067094344 @default.
- W4293789078 cites W2075420402 @default.
- W4293789078 cites W2076654042 @default.
- W4293789078 cites W2084023408 @default.
- W4293789078 cites W2084443965 @default.
- W4293789078 cites W2097036998 @default.
- W4293789078 cites W2103745407 @default.
- W4293789078 cites W2118610203 @default.
- W4293789078 cites W2120532948 @default.
- W4293789078 cites W2123739790 @default.
- W4293789078 cites W2125295858 @default.
- W4293789078 cites W2127301146 @default.
- W4293789078 cites W2139886607 @default.
- W4293789078 cites W2142864721 @default.
- W4293789078 cites W2151721316 @default.
- W4293789078 cites W2154973096 @default.
- W4293789078 cites W2155183231 @default.
- W4293789078 cites W2167136960 @default.
- W4293789078 cites W2168897511 @default.
- W4293789078 cites W2180747267 @default.
- W4293789078 cites W2183249629 @default.
- W4293789078 cites W2186765448 @default.
- W4293789078 cites W2192218028 @default.
- W4293789078 cites W2215675716 @default.
- W4293789078 cites W2218014119 @default.
- W4293789078 cites W2274079979 @default.
- W4293789078 cites W2299603905 @default.
- W4293789078 cites W2300236549 @default.
- W4293789078 cites W2346618440 @default.
- W4293789078 cites W2394583211 @default.
- W4293789078 cites W2483375907 @default.
- W4293789078 cites W2516989289 @default.
- W4293789078 cites W2576559149 @default.
- W4293789078 cites W2591835185 @default.
- W4293789078 cites W2593114254 @default.