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- W4293792854 abstract "Abstract: Alzheimer’s disease (AD) is considered one of the most complicated neurodegenerative disorders, and it is associated with progressive memory loss and remarkable neurocognitive dysfunction that negatively impacts the ability to perform daily living activities. AD accounts for an estimated 60-80% of dementia cases. AD's previously known pathological basis is the deposition of amyloid β (Aβ) aggregates and the formation of neurofibrillary tangles by tau hyperphosphorylation in the cell bodies of neurons that are located in the hippocampus, neocortex, and certain other regions of the cerebral hemispheres and limbic system. The lack of neurotransmitter acetylcholine and the activation of oxidative stress cascade may also contribute to the pathogenesis of AD. These pathological events can lead to irreversible loss of neuronal networks and the emergence of memory impairment and cognitive dysfunction that can engender an abnormal change in the personality. AD cannot be cured, and to some extent, the prescribed medications can only manage the symptoms associated with this disease. Several studies have reported that the regenerative abilities of neural stem/progenitor cells (NSCs) remarkably decline in AD, which disturbs the balancing power to control its progression. Exogenous infusion or endogenous activation of NSCs may be the ultimate solution to restore the neuronal networks in the brain of AD patients and regenerate the damaged areas responsible for memory and cognition. In this mini-review, we will touch upon the fate of NSCs in AD and the utilization of neurogenesis using modified NSCs to restore cognitive functions in AD." @default.
- W4293792854 created "2022-08-31" @default.
- W4293792854 creator A5015496293 @default.
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- W4293792854 creator A5057146109 @default.
- W4293792854 creator A5081911965 @default.
- W4293792854 date "2023-07-01" @default.
- W4293792854 modified "2023-10-16" @default.
- W4293792854 title "The Molecular and Functional Changes of Neural Stem Cells in Alzheimer’s Disease: Can They be Reinvigorated to Conduct Neurogenesis" @default.
- W4293792854 cites W1487852103 @default.
- W4293792854 cites W1543871129 @default.
- W4293792854 cites W1547581699 @default.
- W4293792854 cites W1589552381 @default.
- W4293792854 cites W1597163915 @default.
- W4293792854 cites W1605885548 @default.
- W4293792854 cites W1682771183 @default.
- W4293792854 cites W1836539731 @default.
- W4293792854 cites W1866745427 @default.
- W4293792854 cites W1942922429 @default.
- W4293792854 cites W1959902108 @default.
- W4293792854 cites W1972047429 @default.
- W4293792854 cites W1980499453 @default.
- W4293792854 cites W1990806594 @default.
- W4293792854 cites W1994672714 @default.
- W4293792854 cites W1996705438 @default.
- W4293792854 cites W2003770008 @default.
- W4293792854 cites W2014094971 @default.
- W4293792854 cites W2018496107 @default.
- W4293792854 cites W2023856407 @default.
- W4293792854 cites W2026273618 @default.
- W4293792854 cites W2028776222 @default.
- W4293792854 cites W2040925087 @default.
- W4293792854 cites W2044814509 @default.
- W4293792854 cites W2047349884 @default.
- W4293792854 cites W2049192526 @default.
- W4293792854 cites W2053276015 @default.
- W4293792854 cites W2055889984 @default.
- W4293792854 cites W2057768353 @default.
- W4293792854 cites W2066027939 @default.
- W4293792854 cites W2067856703 @default.
- W4293792854 cites W2070448139 @default.
- W4293792854 cites W2073252618 @default.
- W4293792854 cites W2074630757 @default.
- W4293792854 cites W2075670261 @default.
- W4293792854 cites W2076412273 @default.
- W4293792854 cites W2087619081 @default.
- W4293792854 cites W2089081506 @default.
- W4293792854 cites W2093948474 @default.
- W4293792854 cites W2094573053 @default.
- W4293792854 cites W2094606090 @default.
- W4293792854 cites W2094958540 @default.
- W4293792854 cites W2099751992 @default.
- W4293792854 cites W2101584823 @default.
- W4293792854 cites W2110232685 @default.
- W4293792854 cites W2136097257 @default.
- W4293792854 cites W2147813206 @default.
- W4293792854 cites W2149901479 @default.
- W4293792854 cites W2150684193 @default.
- W4293792854 cites W2154908600 @default.
- W4293792854 cites W2162059739 @default.
- W4293792854 cites W2163218783 @default.
- W4293792854 cites W2164808240 @default.
- W4293792854 cites W2168528461 @default.
- W4293792854 cites W2460270380 @default.
- W4293792854 cites W2514727659 @default.
- W4293792854 cites W2560682758 @default.
- W4293792854 cites W2565734636 @default.
- W4293792854 cites W2569051176 @default.
- W4293792854 cites W2601518322 @default.
- W4293792854 cites W2608654234 @default.
- W4293792854 cites W2734651019 @default.
- W4293792854 cites W2746324332 @default.
- W4293792854 cites W2789023274 @default.
- W4293792854 cites W2801769333 @default.
- W4293792854 cites W2804942342 @default.
- W4293792854 cites W2892192571 @default.
- W4293792854 cites W2894477662 @default.
- W4293792854 cites W2896130532 @default.
- W4293792854 cites W2898865988 @default.
- W4293792854 cites W2913604250 @default.
- W4293792854 cites W2917730449 @default.
- W4293792854 cites W2920391004 @default.
- W4293792854 cites W2920901214 @default.
- W4293792854 cites W2922180568 @default.
- W4293792854 cites W2923525506 @default.
- W4293792854 cites W2925056974 @default.
- W4293792854 cites W2945693197 @default.
- W4293792854 cites W2965717703 @default.
- W4293792854 cites W2969562288 @default.
- W4293792854 cites W2970328431 @default.
- W4293792854 cites W2979089456 @default.
- W4293792854 cites W2985515770 @default.
- W4293792854 cites W2992486783 @default.
- W4293792854 cites W2998922852 @default.
- W4293792854 cites W3001721938 @default.
- W4293792854 cites W3011315185 @default.
- W4293792854 cites W3014145990 @default.