Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293795540> ?p ?o ?g. }
- W4293795540 endingPage "e1010448" @default.
- W4293795540 startingPage "e1010448" @default.
- W4293795540 abstract "We propose a novel heuristic to predict RNA secondary structure formation pathways that has two components: (i) a folding algorithm and (ii) a kinetic ansatz. This heuristic is inspired by the kinetic partitioning mechanism, by which molecules follow alternative folding pathways to their native structure, some much faster than others. Similarly, our algorithm RAFFT starts by generating an ensemble of concurrent folding pathways ending in multiple metastable structures, which is in contrast with traditional thermodynamic approaches that find single structures with minimal free energies. When we constrained the algorithm to predict only 50 structures per sequence, near-native structures were found for RNA molecules of length ≤ 200 nucleotides. Our heuristic has been tested on the coronavirus frameshifting stimulation element (CFSE): an ensemble of 68 distinct structures allowed us to produce complete folding kinetic trajectories, whereas known methods require evaluating millions of sub-optimal structures to achieve this result. Thanks to the fast Fourier transform on which RAFFT (RNA folding Algorithm wih Fast Fourier Transform) is based, these computations are efficient, with complexity [Formula: see text]." @default.
- W4293795540 created "2022-08-31" @default.
- W4293795540 creator A5062852680 @default.
- W4293795540 creator A5072262870 @default.
- W4293795540 creator A5076789548 @default.
- W4293795540 creator A5090059320 @default.
- W4293795540 date "2022-08-26" @default.
- W4293795540 modified "2023-10-18" @default.
- W4293795540 title "RAFFT: Efficient prediction of RNA folding pathways using the fast Fourier transform" @default.
- W4293795540 cites W166206240 @default.
- W4293795540 cites W1967538502 @default.
- W4293795540 cites W1974708169 @default.
- W4293795540 cites W1976021976 @default.
- W4293795540 cites W1988884185 @default.
- W4293795540 cites W1996609063 @default.
- W4293795540 cites W1999410197 @default.
- W4293795540 cites W2004945910 @default.
- W4293795540 cites W2009818318 @default.
- W4293795540 cites W2025374847 @default.
- W4293795540 cites W2025763720 @default.
- W4293795540 cites W2028335053 @default.
- W4293795540 cites W2053161102 @default.
- W4293795540 cites W2054010580 @default.
- W4293795540 cites W2063040421 @default.
- W4293795540 cites W2065225159 @default.
- W4293795540 cites W2066964638 @default.
- W4293795540 cites W2068205741 @default.
- W4293795540 cites W2079532263 @default.
- W4293795540 cites W2079571677 @default.
- W4293795540 cites W2080251448 @default.
- W4293795540 cites W2086561953 @default.
- W4293795540 cites W2088528526 @default.
- W4293795540 cites W2096838621 @default.
- W4293795540 cites W2096883982 @default.
- W4293795540 cites W2098571862 @default.
- W4293795540 cites W2102225325 @default.
- W4293795540 cites W2103250001 @default.
- W4293795540 cites W2106478835 @default.
- W4293795540 cites W2109638684 @default.
- W4293795540 cites W2116733241 @default.
- W4293795540 cites W2116824254 @default.
- W4293795540 cites W2123768455 @default.
- W4293795540 cites W2130032853 @default.
- W4293795540 cites W2134453550 @default.
- W4293795540 cites W2137583795 @default.
- W4293795540 cites W2141157874 @default.
- W4293795540 cites W2141351700 @default.
- W4293795540 cites W2143407915 @default.
- W4293795540 cites W2159117141 @default.
- W4293795540 cites W2162224067 @default.
- W4293795540 cites W2162310257 @default.
- W4293795540 cites W2164408046 @default.
- W4293795540 cites W2167673850 @default.
- W4293795540 cites W2536860838 @default.
- W4293795540 cites W2567361281 @default.
- W4293795540 cites W2725568163 @default.
- W4293795540 cites W2775336518 @default.
- W4293795540 cites W2933083636 @default.
- W4293795540 cites W2954102902 @default.
- W4293795540 cites W2990528340 @default.
- W4293795540 cites W3022948658 @default.
- W4293795540 cites W3024389904 @default.
- W4293795540 cites W3048927351 @default.
- W4293795540 cites W3098158996 @default.
- W4293795540 cites W3122583070 @default.
- W4293795540 cites W3126773939 @default.
- W4293795540 cites W4212805598 @default.
- W4293795540 cites W4234887284 @default.
- W4293795540 cites W4245270879 @default.
- W4293795540 cites W4255547833 @default.
- W4293795540 doi "https://doi.org/10.1371/journal.pcbi.1010448" @default.
- W4293795540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36026505" @default.
- W4293795540 hasPublicationYear "2022" @default.
- W4293795540 type Work @default.
- W4293795540 citedByCount "0" @default.
- W4293795540 crossrefType "journal-article" @default.
- W4293795540 hasAuthorship W4293795540A5062852680 @default.
- W4293795540 hasAuthorship W4293795540A5072262870 @default.
- W4293795540 hasAuthorship W4293795540A5076789548 @default.
- W4293795540 hasAuthorship W4293795540A5090059320 @default.
- W4293795540 hasBestOaLocation W42937955401 @default.
- W4293795540 hasConcept C102519508 @default.
- W4293795540 hasConcept C104317684 @default.
- W4293795540 hasConcept C11413529 @default.
- W4293795540 hasConcept C119599485 @default.
- W4293795540 hasConcept C121332964 @default.
- W4293795540 hasConcept C121864883 @default.
- W4293795540 hasConcept C126142528 @default.
- W4293795540 hasConcept C127413603 @default.
- W4293795540 hasConcept C154945302 @default.
- W4293795540 hasConcept C173801870 @default.
- W4293795540 hasConcept C185592680 @default.
- W4293795540 hasConcept C186060115 @default.
- W4293795540 hasConcept C2776545253 @default.
- W4293795540 hasConcept C41008148 @default.
- W4293795540 hasConcept C55493867 @default.
- W4293795540 hasConcept C62520636 @default.
- W4293795540 hasConcept C67705224 @default.