FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293799664> ?p ?o ?g. }

• W4293799664 abstract "Abstract Motivation Genome-wide association studies (GWAS) have been successful in identifying genetic variants associated with a particular phenotype. However, many complex phenotypes are influenced by multiple genetic variants with small effects. Detecting the genetic pleiotropy can provide insights into biological mechanisms influencing complex human phenotypes. The recently developed Multivariate Omnibus Statistical Test (MOSTest) has proven to be efficient and powerful, suited for complex large-scale data. The method substantially increased discovery of genetic variants associated with brain MRI phenotypes in the UK Biobank compared to conventionally use multivariate approach. Here we extend the MOSTest to meta-analysis (Meta-MOSTest), facilitating data analysis of multiple phenotypes across multiple cohorts. We evaluated our updated approach in the UK Biobank using brain MRI phenotypes, by comparing the discovery yield of the single-cohort MOSTest versus Meta-MOSTest through simulating sub-cohorts of different sample sizes from 265 to 26501 subjects. Results Our method works efficiently on large-scale cohorts with a large number of MRI phenotypes. We found that lower per-cohort sample sizes resulted in a reduced discovery yield indicating a loss of statistical power. However, with a minimum sample size of 250 subjects across cohorts, Meta-MOSTest was equivalent to MOSTest on discovery yield while maintaining a well-calibrated type I error and equivalent statistical power. We conclude that Meta-MOSTest is a useful tool for multivariate analysis across separate brain imaging genetics cohorts. Availability and implementation All codes are freely available on GitHub: MOSTest and Meta-MOSTest ." @default.
• W4293799664 created "2022-08-31" @default.
• W4293799664 creator A5001013367 @default.
• W4293799664 creator A5005956415 @default.
• W4293799664 creator A5017692684 @default.
• W4293799664 creator A5022164078 @default.
• W4293799664 creator A5036498380 @default.
• W4293799664 creator A5036630445 @default.
• W4293799664 creator A5042733882 @default.
• W4293799664 creator A5057699254 @default.
• W4293799664 creator A5058922815 @default.
• W4293799664 creator A5064324947 @default.
• W4293799664 creator A5073483045 @default.
• W4293799664 creator A5080862545 @default.
• W4293799664 creator A5081056837 @default.
• W4293799664 creator A5084649001 @default.
• W4293799664 creator A5085703840 @default.
• W4293799664 creator A5087626511 @default.
• W4293799664 date "2022-08-18" @default.
• W4293799664 modified "2023-10-16" @default.
• W4293799664 title "Efficient meta-analysis of multivariate genome-wide association studies with Meta-MOSTest" @default.
• W4293799664 cites W1982636457 @default.
• W4293799664 cites W1991739837 @default.
• W4293799664 cites W1996299724 @default.
• W4293799664 cites W2051616601 @default.
• W4293799664 cites W2082704080 @default.
• W4293799664 cites W2117613972 @default.
• W4293799664 cites W2133520037 @default.
• W4293799664 cites W2163924952 @default.
• W4293799664 cites W2302979210 @default.
• W4293799664 cites W2605739185 @default.
• W4293799664 cites W2609984900 @default.
• W4293799664 cites W2770092353 @default.
• W4293799664 cites W2773164960 @default.
• W4293799664 cites W2895486342 @default.
• W4293799664 cites W2969726224 @default.
• W4293799664 cites W2979994192 @default.
• W4293799664 cites W3011154449 @default.
• W4293799664 cites W3012009865 @default.
• W4293799664 cites W3043091543 @default.
• W4293799664 cites W3102771604 @default.
• W4293799664 cites W3158734898 @default.
• W4293799664 cites W3186343381 @default.
• W4293799664 cites W3201415496 @default.
• W4293799664 cites W4236182060 @default.
• W4293799664 doi "https://doi.org/10.1101/2022.08.18.504383" @default.
• W4293799664 hasPublicationYear "2022" @default.
• W4293799664 type Work @default.
• W4293799664 citedByCount "0" @default.
• W4293799664 crossrefType "posted-content" @default.
• W4293799664 hasAuthorship W4293799664A5001013367 @default.
• W4293799664 hasAuthorship W4293799664A5005956415 @default.
• W4293799664 hasAuthorship W4293799664A5017692684 @default.
• W4293799664 hasAuthorship W4293799664A5022164078 @default.
• W4293799664 hasAuthorship W4293799664A5036498380 @default.
• W4293799664 hasAuthorship W4293799664A5036630445 @default.
• W4293799664 hasAuthorship W4293799664A5042733882 @default.
• W4293799664 hasAuthorship W4293799664A5057699254 @default.
• W4293799664 hasAuthorship W4293799664A5058922815 @default.
• W4293799664 hasAuthorship W4293799664A5064324947 @default.
• W4293799664 hasAuthorship W4293799664A5073483045 @default.
• W4293799664 hasAuthorship W4293799664A5080862545 @default.
• W4293799664 hasAuthorship W4293799664A5081056837 @default.
• W4293799664 hasAuthorship W4293799664A5084649001 @default.
• W4293799664 hasAuthorship W4293799664A5085703840 @default.
• W4293799664 hasAuthorship W4293799664A5087626511 @default.
• W4293799664 hasBestOaLocation W42937996641 @default.
• W4293799664 hasConcept C104317684 @default.
• W4293799664 hasConcept C105795698 @default.
• W4293799664 hasConcept C106208931 @default.
• W4293799664 hasConcept C116567970 @default.
• W4293799664 hasConcept C126322002 @default.
• W4293799664 hasConcept C127716648 @default.
• W4293799664 hasConcept C129848803 @default.
• W4293799664 hasConcept C135763542 @default.
• W4293799664 hasConcept C153209595 @default.
• W4293799664 hasConcept C161584116 @default.
• W4293799664 hasConcept C169760540 @default.
• W4293799664 hasConcept C18183760 @default.
• W4293799664 hasConcept C183905921 @default.
• W4293799664 hasConcept C186413461 @default.
• W4293799664 hasConcept C193244246 @default.
• W4293799664 hasConcept C26207810 @default.
• W4293799664 hasConcept C33923547 @default.
• W4293799664 hasConcept C38180746 @default.
• W4293799664 hasConcept C40696583 @default.
• W4293799664 hasConcept C54355233 @default.
• W4293799664 hasConcept C58693492 @default.
• W4293799664 hasConcept C60644358 @default.
• W4293799664 hasConcept C70721500 @default.
• W4293799664 hasConcept C71924100 @default.
• W4293799664 hasConcept C86803240 @default.
• W4293799664 hasConcept C95190672 @default.
• W4293799664 hasConcept C96608239 @default.
• W4293799664 hasConceptScore W4293799664C104317684 @default.
• W4293799664 hasConceptScore W4293799664C105795698 @default.
• W4293799664 hasConceptScore W4293799664C106208931 @default.
• W4293799664 hasConceptScore W4293799664C116567970 @default.
• W4293799664 hasConceptScore W4293799664C126322002 @default.
• W4293799664 hasConceptScore W4293799664C127716648 @default.

• next