Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293825778> ?p ?o ?g. }
- W4293825778 endingPage "6641" @default.
- W4293825778 startingPage "6626" @default.
- W4293825778 abstract "Acute lung injury (ALI) is commonly accompanied by a severe inflammatory reaction process, and effectively managing inflammatory reactions is an important therapeutic approach for alleviating ALI. Macrophages play an important role in the inflammatory response, and this role is proinflammatory in the early stages of inflammation and anti-inflammatory in the late stages. Oxypeucedanin is a natural product with a wide range of pharmacological functions. This study aimed to determine the effect of oxypeucedanin on lipopolysaccharide (LPS)-induced ALI.In this study, the following experiments were performed based on LPS-induced models in vivo and in vitro. Using myeloperoxidase activity measurement, ELISA, qRT-PCR, and Western blotting, we found that oxypeucedanin modulated the activity of myeloperoxidase and decreased the expression levels of inflammatory mediators such as TNF-α, IL-6, IL-1β, MPO, COX-2 and iNOS in LPS-induced inflammation models. Meanwhile, oxypeucedanin inhibited the activation of PI3K/AKT and its downstream NF-κB and MAPK signaling pathways. In addition, oxypeucedanin significantly decreased the pulmonary vascular permeability, which was induced by LPSs, and the enhanced expression of tight junction proteins (Occludin and Claudin 3).In conclusion, this study demonstrated that the anti-inflammatory mechanism of oxypeucedanin is associated with the inhibition of the activation of PI3K/AKT/NF-κB and MAPK signaling pathways and the maintenance of the integrity of the lung air-blood barrier." @default.
- W4293825778 created "2022-08-31" @default.
- W4293825778 creator A5015195367 @default.
- W4293825778 creator A5055056198 @default.
- W4293825778 creator A5056788729 @default.
- W4293825778 creator A5057912307 @default.
- W4293825778 creator A5062457915 @default.
- W4293825778 creator A5073501391 @default.
- W4293825778 creator A5083087033 @default.
- W4293825778 creator A5086989763 @default.
- W4293825778 creator A5089295072 @default.
- W4293825778 date "2022-08-18" @default.
- W4293825778 modified "2023-10-08" @default.
- W4293825778 title "Oxypeucedanin relieves LPS-induced acute lung injury by inhibiting the inflammation and maintaining the integrity of the lung air-blood barrier" @default.
- W4293825778 cites W1524998078 @default.
- W4293825778 cites W1587977098 @default.
- W4293825778 cites W1986289112 @default.
- W4293825778 cites W1990698518 @default.
- W4293825778 cites W2022561792 @default.
- W4293825778 cites W2024160120 @default.
- W4293825778 cites W2033699985 @default.
- W4293825778 cites W2061412618 @default.
- W4293825778 cites W2071963896 @default.
- W4293825778 cites W2094244393 @default.
- W4293825778 cites W2112610954 @default.
- W4293825778 cites W2118044708 @default.
- W4293825778 cites W2122248278 @default.
- W4293825778 cites W2154458783 @default.
- W4293825778 cites W2155957079 @default.
- W4293825778 cites W2157600239 @default.
- W4293825778 cites W2162328609 @default.
- W4293825778 cites W2189189247 @default.
- W4293825778 cites W2218297900 @default.
- W4293825778 cites W2313799384 @default.
- W4293825778 cites W2317488575 @default.
- W4293825778 cites W2530157596 @default.
- W4293825778 cites W2547435892 @default.
- W4293825778 cites W2606430458 @default.
- W4293825778 cites W2610282276 @default.
- W4293825778 cites W2620241325 @default.
- W4293825778 cites W2623145016 @default.
- W4293825778 cites W2747299546 @default.
- W4293825778 cites W2774917626 @default.
- W4293825778 cites W2802595885 @default.
- W4293825778 cites W2888464037 @default.
- W4293825778 cites W2899421377 @default.
- W4293825778 cites W2914043191 @default.
- W4293825778 cites W2919364499 @default.
- W4293825778 cites W2941766873 @default.
- W4293825778 cites W2951409566 @default.
- W4293825778 cites W2970433500 @default.
- W4293825778 cites W2974093146 @default.
- W4293825778 cites W2975498643 @default.
- W4293825778 cites W2984337944 @default.
- W4293825778 cites W3004061483 @default.
- W4293825778 cites W3024536180 @default.
- W4293825778 cites W3035874764 @default.
- W4293825778 cites W3047284551 @default.
- W4293825778 cites W3089518794 @default.
- W4293825778 cites W4211250103 @default.
- W4293825778 cites W2884619204 @default.
- W4293825778 doi "https://doi.org/10.18632/aging.204235" @default.
- W4293825778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35985771" @default.
- W4293825778 hasPublicationYear "2022" @default.
- W4293825778 type Work @default.
- W4293825778 citedByCount "1" @default.
- W4293825778 countsByYear W42938257782023 @default.
- W4293825778 crossrefType "journal-article" @default.
- W4293825778 hasAuthorship W4293825778A5015195367 @default.
- W4293825778 hasAuthorship W4293825778A5055056198 @default.
- W4293825778 hasAuthorship W4293825778A5056788729 @default.
- W4293825778 hasAuthorship W4293825778A5057912307 @default.
- W4293825778 hasAuthorship W4293825778A5062457915 @default.
- W4293825778 hasAuthorship W4293825778A5073501391 @default.
- W4293825778 hasAuthorship W4293825778A5083087033 @default.
- W4293825778 hasAuthorship W4293825778A5086989763 @default.
- W4293825778 hasAuthorship W4293825778A5089295072 @default.
- W4293825778 hasBestOaLocation W42938257781 @default.
- W4293825778 hasConcept C126322002 @default.
- W4293825778 hasConcept C150903083 @default.
- W4293825778 hasConcept C164027704 @default.
- W4293825778 hasConcept C177779419 @default.
- W4293825778 hasConcept C17991360 @default.
- W4293825778 hasConcept C185592680 @default.
- W4293825778 hasConcept C203014093 @default.
- W4293825778 hasConcept C203565725 @default.
- W4293825778 hasConcept C207001950 @default.
- W4293825778 hasConcept C2775962179 @default.
- W4293825778 hasConcept C2776914184 @default.
- W4293825778 hasConcept C2777714996 @default.
- W4293825778 hasConcept C2778754761 @default.
- W4293825778 hasConcept C55493867 @default.
- W4293825778 hasConcept C57074206 @default.
- W4293825778 hasConcept C62478195 @default.
- W4293825778 hasConcept C71924100 @default.
- W4293825778 hasConcept C75217442 @default.
- W4293825778 hasConcept C86554907 @default.
- W4293825778 hasConcept C86803240 @default.