Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293828781> ?p ?o ?g. }
- W4293828781 endingPage "20" @default.
- W4293828781 startingPage "20" @default.
- W4293828781 abstract "The purpose of this paper was to investigate the expression and function of Ubiquitin-conjugating enzyme 2T (UBE2T), a human E2 ubiquitin-conjugating enzyme, in human retinoblastoma.The expression of UBE2T in normal retina and retinoblastoma was analyzed using the Gene Expression Omnibus (GEO) databases, and its expression was immunohistochemically evaluated in 29 retinoblastoma sections and 5 normal retinas. Then CCK-8, flow cytometry, RNA-sequencing analysis, and in vivo assays were performed to explore the exact role of UBE2T in retinoblastoma.We found that retinoblastoma showed higher UBE2T expression than normal retina in GEO datasets and tissues. The immunoreactive score of UBE2T ≥4 was associated with group E in IIRC, T2-T4b in pTNM staging, poorly differentiated retinoblastoma, and high-risk histopathological factors. Knockdown of UBE2T reduced the cell viability, increased the apoptosis cells and G0/G1 cells, and inhibited subcutaneous tumor growth in vivo. Mechanistic studies showed that UBE2T knockdown induced down-regulation of phosphorylation of STAT3 and its downstream genes in vitro and in vivo. Rescue assays confirmed that STAT3 signaling pathway was involved in the effect of reduced cell viability, elevated apoptosis cells, and G0/G1 cells mediated by UBE2T knockdown.Our data indicate that UBE2T significantly participates in the proliferation of retinoblastoma via the STAT3 signaling pathway, suggesting the potential of UBE2T as a therapeutic target for retinoblastoma treatment." @default.
- W4293828781 created "2022-08-31" @default.
- W4293828781 creator A5030887743 @default.
- W4293828781 creator A5034389685 @default.
- W4293828781 creator A5037722886 @default.
- W4293828781 creator A5048307621 @default.
- W4293828781 creator A5053448155 @default.
- W4293828781 creator A5062499925 @default.
- W4293828781 creator A5085022758 @default.
- W4293828781 date "2022-08-18" @default.
- W4293828781 modified "2023-10-18" @default.
- W4293828781 title "UBE2T/STAT3 Signaling Promotes the Proliferation and Tumorigenesis in Retinoblastoma" @default.
- W4293828781 cites W1607577125 @default.
- W4293828781 cites W1844379777 @default.
- W4293828781 cites W1902808961 @default.
- W4293828781 cites W1904404816 @default.
- W4293828781 cites W1991846801 @default.
- W4293828781 cites W1996170398 @default.
- W4293828781 cites W2043652375 @default.
- W4293828781 cites W2046526227 @default.
- W4293828781 cites W2056473812 @default.
- W4293828781 cites W2075445493 @default.
- W4293828781 cites W2077858999 @default.
- W4293828781 cites W2078990441 @default.
- W4293828781 cites W2091232957 @default.
- W4293828781 cites W2108113310 @default.
- W4293828781 cites W2122129374 @default.
- W4293828781 cites W2130410032 @default.
- W4293828781 cites W2141680498 @default.
- W4293828781 cites W2145079065 @default.
- W4293828781 cites W2145632098 @default.
- W4293828781 cites W2147247243 @default.
- W4293828781 cites W2162139554 @default.
- W4293828781 cites W2166834621 @default.
- W4293828781 cites W2209085507 @default.
- W4293828781 cites W2288602875 @default.
- W4293828781 cites W2312318678 @default.
- W4293828781 cites W2529916409 @default.
- W4293828781 cites W2593558331 @default.
- W4293828781 cites W2618558825 @default.
- W4293828781 cites W2773385110 @default.
- W4293828781 cites W2777457443 @default.
- W4293828781 cites W2883052277 @default.
- W4293828781 cites W2973092482 @default.
- W4293828781 cites W2989585224 @default.
- W4293828781 cites W3007512002 @default.
- W4293828781 cites W3021995301 @default.
- W4293828781 cites W3022897882 @default.
- W4293828781 cites W3037691608 @default.
- W4293828781 cites W3113544096 @default.
- W4293828781 cites W3128850675 @default.
- W4293828781 cites W3135995749 @default.
- W4293828781 cites W4230348919 @default.
- W4293828781 cites W4239772487 @default.
- W4293828781 cites W4248212788 @default.
- W4293828781 cites W4255332023 @default.
- W4293828781 doi "https://doi.org/10.1167/iovs.63.9.20" @default.
- W4293828781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35980647" @default.
- W4293828781 hasPublicationYear "2022" @default.
- W4293828781 type Work @default.
- W4293828781 citedByCount "1" @default.
- W4293828781 countsByYear W42938287812023 @default.
- W4293828781 crossrefType "journal-article" @default.
- W4293828781 hasAuthorship W4293828781A5030887743 @default.
- W4293828781 hasAuthorship W4293828781A5034389685 @default.
- W4293828781 hasAuthorship W4293828781A5037722886 @default.
- W4293828781 hasAuthorship W4293828781A5048307621 @default.
- W4293828781 hasAuthorship W4293828781A5053448155 @default.
- W4293828781 hasAuthorship W4293828781A5062499925 @default.
- W4293828781 hasAuthorship W4293828781A5085022758 @default.
- W4293828781 hasBestOaLocation W42938287811 @default.
- W4293828781 hasConcept C104317684 @default.
- W4293828781 hasConcept C134459356 @default.
- W4293828781 hasConcept C153911025 @default.
- W4293828781 hasConcept C173396325 @default.
- W4293828781 hasConcept C182561583 @default.
- W4293828781 hasConcept C190283241 @default.
- W4293828781 hasConcept C25602115 @default.
- W4293828781 hasConcept C2776577112 @default.
- W4293828781 hasConcept C29537977 @default.
- W4293828781 hasConcept C502942594 @default.
- W4293828781 hasConcept C53227056 @default.
- W4293828781 hasConcept C54355233 @default.
- W4293828781 hasConcept C553184892 @default.
- W4293828781 hasConcept C555283112 @default.
- W4293828781 hasConcept C62112901 @default.
- W4293828781 hasConcept C86803240 @default.
- W4293828781 hasConceptScore W4293828781C104317684 @default.
- W4293828781 hasConceptScore W4293828781C134459356 @default.
- W4293828781 hasConceptScore W4293828781C153911025 @default.
- W4293828781 hasConceptScore W4293828781C173396325 @default.
- W4293828781 hasConceptScore W4293828781C182561583 @default.
- W4293828781 hasConceptScore W4293828781C190283241 @default.
- W4293828781 hasConceptScore W4293828781C25602115 @default.
- W4293828781 hasConceptScore W4293828781C2776577112 @default.
- W4293828781 hasConceptScore W4293828781C29537977 @default.
- W4293828781 hasConceptScore W4293828781C502942594 @default.
- W4293828781 hasConceptScore W4293828781C53227056 @default.