FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293860302> ?p ?o ?g. }

• W4293860302 endingPage "3136" @default.
• W4293860302 startingPage "3125" @default.
• W4293860302 abstract "Abstract Background The lipid scavenger receptor cluster of differentiation 36 (CD36) has been shown to have a pro-metastatic function in several cancers. Adipose tissue, a favorable site for peritoneal metastasis (PM) from gastric cancer (GC), promotes this process by providing free fatty acids (FFAs); however, the role of CD36 in PM progression from GC remains to be elucidated. Materials and Methods We evaluated CD36 expression in the GC cells under various conditions. CD36 overexpressing (CD36OE) MKN45 cells were prepared and their migration and invasive properties were assessed. A PM mouse model was used to investigate the biological effects of palmitic acid (PA) and CD36. Furthermore, we examined the clinical role of CD36 expression in 82 human PM samples by immunohistochemical staining. Results Hypoxia markedly increased CD36 expression in GC cells. In normoxia, only CD36OE MKN45 cells treated with PA showed an increase in migration and invasion abilities. An increased expression of active Rac1 and Cdc42 was observed, which decreased following etomoxir treatment. Conversely, hypoxia increased those capacities of both vector and CD36OE MKN45 cells. In a mouse model transplanted with CD36OE MKN45 cells, more peritoneal tumors were observed in the high-fat diet group than those in the normal diet group. In clinical samples, 80% of PM lesions expressed CD36, consistent with hypoxic regions, indicating a significant association with prognosis. Conclusion Our findings indicate that a hypoxia in the peritoneal cavity induces CD36 expression in GC cells, which contributes to PM through the uptake of FFAs." @default.
• W4293860302 created "2022-09-01" @default.
• W4293860302 creator A5000691284 @default.
• W4293860302 creator A5018007136 @default.
• W4293860302 creator A5024644803 @default.
• W4293860302 creator A5042364574 @default.
• W4293860302 creator A5047407485 @default.
• W4293860302 creator A5049329632 @default.
• W4293860302 creator A5067280388 @default.
• W4293860302 creator A5068839216 @default.
• W4293860302 creator A5072194347 @default.
• W4293860302 creator A5079171795 @default.
• W4293860302 creator A5081758735 @default.
• W4293860302 creator A5084113589 @default.
• W4293860302 creator A5089204693 @default.
• W4293860302 date "2022-08-30" @default.
• W4293860302 modified "2023-10-14" @default.
• W4293860302 title "Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake" @default.
• W4293860302 cites W1656032348 @default.
• W4293860302 cites W1927044883 @default.
• W4293860302 cites W1984150991 @default.
• W4293860302 cites W2023947368 @default.
• W4293860302 cites W2038653853 @default.
• W4293860302 cites W2043213668 @default.
• W4293860302 cites W2046178144 @default.
• W4293860302 cites W2057001750 @default.
• W4293860302 cites W2093236829 @default.
• W4293860302 cites W2100628130 @default.
• W4293860302 cites W2107542389 @default.
• W4293860302 cites W2117594441 @default.
• W4293860302 cites W2225173575 @default.
• W4293860302 cites W2315243978 @default.
• W4293860302 cites W2405125912 @default.
• W4293860302 cites W2560396365 @default.
• W4293860302 cites W2607120474 @default.
• W4293860302 cites W2739442195 @default.
• W4293860302 cites W2793124274 @default.
• W4293860302 cites W2803860693 @default.
• W4293860302 cites W2912783569 @default.
• W4293860302 cites W2913214687 @default.
• W4293860302 cites W2922081884 @default.
• W4293860302 cites W2950427522 @default.
• W4293860302 cites W2962908114 @default.
• W4293860302 cites W3004314471 @default.
• W4293860302 cites W3027294383 @default.
• W4293860302 cites W3034999789 @default.
• W4293860302 cites W3048396564 @default.
• W4293860302 cites W3188984966 @default.
• W4293860302 cites W4205974322 @default.
• W4293860302 cites W4282583350 @default.
• W4293860302 doi "https://doi.org/10.1245/s10434-022-12465-5" @default.
• W4293860302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36042102" @default.
• W4293860302 hasPublicationYear "2022" @default.
• W4293860302 type Work @default.
• W4293860302 citedByCount "5" @default.
• W4293860302 countsByYear W42938603022022 @default.
• W4293860302 countsByYear W42938603022023 @default.
• W4293860302 crossrefType "journal-article" @default.
• W4293860302 hasAuthorship W4293860302A5000691284 @default.
• W4293860302 hasAuthorship W4293860302A5018007136 @default.
• W4293860302 hasAuthorship W4293860302A5024644803 @default.
• W4293860302 hasAuthorship W4293860302A5042364574 @default.
• W4293860302 hasAuthorship W4293860302A5047407485 @default.
• W4293860302 hasAuthorship W4293860302A5049329632 @default.
• W4293860302 hasAuthorship W4293860302A5067280388 @default.
• W4293860302 hasAuthorship W4293860302A5068839216 @default.
• W4293860302 hasAuthorship W4293860302A5072194347 @default.
• W4293860302 hasAuthorship W4293860302A5079171795 @default.
• W4293860302 hasAuthorship W4293860302A5081758735 @default.
• W4293860302 hasAuthorship W4293860302A5084113589 @default.
• W4293860302 hasAuthorship W4293860302A5089204693 @default.
• W4293860302 hasBestOaLocation W42938603021 @default.
• W4293860302 hasConcept C121608353 @default.
• W4293860302 hasConcept C126322002 @default.
• W4293860302 hasConcept C170493617 @default.
• W4293860302 hasConcept C178790620 @default.
• W4293860302 hasConcept C185592680 @default.
• W4293860302 hasConcept C204232928 @default.
• W4293860302 hasConcept C2778163477 @default.
• W4293860302 hasConcept C2779013556 @default.
• W4293860302 hasConcept C2779828298 @default.
• W4293860302 hasConcept C2780072125 @default.
• W4293860302 hasConcept C41443022 @default.
• W4293860302 hasConcept C502942594 @default.
• W4293860302 hasConcept C540031477 @default.
• W4293860302 hasConcept C543025807 @default.
• W4293860302 hasConcept C55493867 @default.
• W4293860302 hasConcept C71924100 @default.
• W4293860302 hasConcept C7836513 @default.
• W4293860302 hasConcept C96232424 @default.
• W4293860302 hasConceptScore W4293860302C121608353 @default.
• W4293860302 hasConceptScore W4293860302C126322002 @default.
• W4293860302 hasConceptScore W4293860302C170493617 @default.
• W4293860302 hasConceptScore W4293860302C178790620 @default.
• W4293860302 hasConceptScore W4293860302C185592680 @default.
• W4293860302 hasConceptScore W4293860302C204232928 @default.
• W4293860302 hasConceptScore W4293860302C2778163477 @default.
• W4293860302 hasConceptScore W4293860302C2779013556 @default.

• next