Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293862805> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4293862805 abstract "Abstract Bacterial cell division begins with the formation of the Z-ring via polymerization of FtsZ and the localization of Z-ring beneath the inner membrane through membrane anchors. In Mycobacterium tuberculosis ( Mtb ), SepF is one such membrane anchor, but our understanding of the underlying mechanism is very limited. Here we used molecular dynamics simulations to characterize how SepF itself, a water-soluble protein, tethers to acidic membranes that mimic the Mtb inner membrane. In addition to an amphipathic helix (residues 1-12) at the N-terminus, membrane binding also occurs through two stretches of positively charged residues (Arg27-Arg 37 and Arg95-Arg107) in the long linker preceding the FtsZ-binding core domain (residues 128-218). The additional interactions via the disordered linker stabilize the membrane tethering of SepF, and keep the core domain of SepF and hence the attached Z-ring close to the membrane. The resulting membrane proximity of the Z-ring in turn enables its interactions with and thus recruitment of two membrane proteins, FtsW and CrgA, at the late stage of cell division." @default.
- W4293862805 created "2022-09-01" @default.
- W4293862805 creator A5003024248 @default.
- W4293862805 creator A5046197938 @default.
- W4293862805 date "2022-08-26" @default.
- W4293862805 modified "2023-09-28" @default.
- W4293862805 title "Membrane Tethering of SepF, a Membrane Anchor for the <i>Mycobacterium tuberculosis</i> Z-ring" @default.
- W4293862805 cites W1505479679 @default.
- W4293862805 cites W1968790827 @default.
- W4293862805 cites W1982344272 @default.
- W4293862805 cites W2025109401 @default.
- W4293862805 cites W2039927551 @default.
- W4293862805 cites W2053278954 @default.
- W4293862805 cites W2053820259 @default.
- W4293862805 cites W2058221863 @default.
- W4293862805 cites W2070067221 @default.
- W4293862805 cites W2124528240 @default.
- W4293862805 cites W2127322768 @default.
- W4293862805 cites W2148547853 @default.
- W4293862805 cites W2154463795 @default.
- W4293862805 cites W2160743667 @default.
- W4293862805 cites W2313116527 @default.
- W4293862805 cites W3014206325 @default.
- W4293862805 cites W3036387298 @default.
- W4293862805 cites W3113039662 @default.
- W4293862805 cites W3177828909 @default.
- W4293862805 cites W4213256310 @default.
- W4293862805 doi "https://doi.org/10.1101/2022.08.26.505433" @default.
- W4293862805 hasPublicationYear "2022" @default.
- W4293862805 type Work @default.
- W4293862805 citedByCount "0" @default.
- W4293862805 crossrefType "posted-content" @default.
- W4293862805 hasAuthorship W4293862805A5003024248 @default.
- W4293862805 hasAuthorship W4293862805A5046197938 @default.
- W4293862805 hasBestOaLocation W42938628051 @default.
- W4293862805 hasConcept C111919701 @default.
- W4293862805 hasConcept C12554922 @default.
- W4293862805 hasConcept C144647389 @default.
- W4293862805 hasConcept C1491633281 @default.
- W4293862805 hasConcept C185592680 @default.
- W4293862805 hasConcept C2776237524 @default.
- W4293862805 hasConcept C2778106830 @default.
- W4293862805 hasConcept C2780557392 @default.
- W4293862805 hasConcept C41008148 @default.
- W4293862805 hasConcept C41625074 @default.
- W4293862805 hasConcept C55493867 @default.
- W4293862805 hasConcept C65871279 @default.
- W4293862805 hasConcept C85813293 @default.
- W4293862805 hasConcept C86803240 @default.
- W4293862805 hasConcept C95444343 @default.
- W4293862805 hasConceptScore W4293862805C111919701 @default.
- W4293862805 hasConceptScore W4293862805C12554922 @default.
- W4293862805 hasConceptScore W4293862805C144647389 @default.
- W4293862805 hasConceptScore W4293862805C1491633281 @default.
- W4293862805 hasConceptScore W4293862805C185592680 @default.
- W4293862805 hasConceptScore W4293862805C2776237524 @default.
- W4293862805 hasConceptScore W4293862805C2778106830 @default.
- W4293862805 hasConceptScore W4293862805C2780557392 @default.
- W4293862805 hasConceptScore W4293862805C41008148 @default.
- W4293862805 hasConceptScore W4293862805C41625074 @default.
- W4293862805 hasConceptScore W4293862805C55493867 @default.
- W4293862805 hasConceptScore W4293862805C65871279 @default.
- W4293862805 hasConceptScore W4293862805C85813293 @default.
- W4293862805 hasConceptScore W4293862805C86803240 @default.
- W4293862805 hasConceptScore W4293862805C95444343 @default.
- W4293862805 hasLocation W42938628051 @default.
- W4293862805 hasOpenAccess W4293862805 @default.
- W4293862805 hasPrimaryLocation W42938628051 @default.
- W4293862805 hasRelatedWork W1995317616 @default.
- W4293862805 hasRelatedWork W2015718391 @default.
- W4293862805 hasRelatedWork W2114774265 @default.
- W4293862805 hasRelatedWork W2124528240 @default.
- W4293862805 hasRelatedWork W2168675257 @default.
- W4293862805 hasRelatedWork W2417662865 @default.
- W4293862805 hasRelatedWork W2998387398 @default.
- W4293862805 hasRelatedWork W3213955149 @default.
- W4293862805 hasRelatedWork W4293862805 @default.
- W4293862805 hasRelatedWork W4295009413 @default.
- W4293862805 isParatext "false" @default.
- W4293862805 isRetracted "false" @default.
- W4293862805 workType "article" @default.