FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293864110> ?p ?o ?g. }

• W4293864110 abstract "Abstract Heterogeneity is the norm in biology. The brain is no different: neuronal cell-types are myriad, reflected through their cellular morphology, type, excitability, connectivity motifs and ion channel distributions. While this biophysical diversity enriches neural systems’ dynamical repertoire, it remains challenging to reconcile with the robustness and persistence of brain function over time. To better understand the relationship between heterogeneity and resilience, we analyzed both analytically and numerically a non-linear sparse neural network with balanced excitatory and inhibitory connections evolving over long time scales. We examined how neural diversity expressed as excitability heterogeneity in this network influences its dynamic volatility (i.e., its susceptibility to critical transitions). We exposed this network to slowly-varying modulatory fluctuations, continuously interrogating its stability and resilience. Our results show that excitability heterogeneity implements a homeostatic control mechanism tuning network stability in a context-dependent way. Such diversity was also found to enhance network resilience, quenching the volatility of its dynamics, effectively making the system independent of changes in many control parameters, such as population size, connection probability, strength and variability of synaptic weights as well as modulatory drive. Taken together, these results highlight the fundamental role played by cell-type heterogeneity in the robustness of brain function in the face of change. Significance Statement Contemporary research has identified widespread cell-to-cell intrinsic diversity in the brain, manifest through variations in biophysical features such as neuronal excitability. A natural question that arises from this phenomenon is what functional role, if any, this heterogeneity might serve. Combining computational and mathematical techniques, this interdisciplinary research shows that intrinsic cell-to-cell diversity, far from mere developmental noise, represents a homeostatic control mechanism, promoting the resilience of neuronal circuits. These results highlight the importance of diversity in the robustness and persistence of brain function over time and in the face of change." @default.
• W4293864110 created "2022-09-01" @default.
• W4293864110 creator A5051915319 @default.
• W4293864110 creator A5068870868 @default.
• W4293864110 creator A5077638875 @default.
• W4293864110 creator A5085273431 @default.
• W4293864110 date "2022-08-26" @default.
• W4293864110 modified "2023-10-17" @default.
• W4293864110 title "Intrinsic neural diversity quenches the dynamic volatility of neural networks" @default.
• W4293864110 cites W1510964369 @default.
• W4293864110 cites W1527468221 @default.
• W4293864110 cites W1598363147 @default.
• W4293864110 cites W1968019923 @default.
• W4293864110 cites W1973383209 @default.
• W4293864110 cites W1974934611 @default.
• W4293864110 cites W1978809795 @default.
• W4293864110 cites W1978864992 @default.
• W4293864110 cites W1985657116 @default.
• W4293864110 cites W1991630689 @default.
• W4293864110 cites W1997587023 @default.
• W4293864110 cites W1997935089 @default.
• W4293864110 cites W1999961963 @default.
• W4293864110 cites W2008284899 @default.
• W4293864110 cites W2011303397 @default.
• W4293864110 cites W2011315779 @default.
• W4293864110 cites W2014995849 @default.
• W4293864110 cites W2015701831 @default.
• W4293864110 cites W2019982458 @default.
• W4293864110 cites W2021752782 @default.
• W4293864110 cites W2025603247 @default.
• W4293864110 cites W2027802883 @default.
• W4293864110 cites W2029215893 @default.
• W4293864110 cites W2032774941 @default.
• W4293864110 cites W2034764513 @default.
• W4293864110 cites W2042737352 @default.
• W4293864110 cites W2049546703 @default.
• W4293864110 cites W2052394872 @default.
• W4293864110 cites W2054914622 @default.
• W4293864110 cites W2058506983 @default.
• W4293864110 cites W2059668389 @default.
• W4293864110 cites W2063206977 @default.
• W4293864110 cites W2064481931 @default.
• W4293864110 cites W2067655607 @default.
• W4293864110 cites W2068478333 @default.
• W4293864110 cites W2069994241 @default.
• W4293864110 cites W2071158443 @default.
• W4293864110 cites W2091603506 @default.
• W4293864110 cites W2092376277 @default.
• W4293864110 cites W2094496560 @default.
• W4293864110 cites W2096301608 @default.
• W4293864110 cites W2102290313 @default.
• W4293864110 cites W2106566258 @default.
• W4293864110 cites W2117469172 @default.
• W4293864110 cites W2119024215 @default.
• W4293864110 cites W2120660679 @default.
• W4293864110 cites W2129240084 @default.
• W4293864110 cites W2131215403 @default.
• W4293864110 cites W2132753014 @default.
• W4293864110 cites W2135937351 @default.
• W4293864110 cites W2136040261 @default.
• W4293864110 cites W2138704896 @default.
• W4293864110 cites W2139919351 @default.
• W4293864110 cites W2141998004 @default.
• W4293864110 cites W2145023731 @default.
• W4293864110 cites W2153268540 @default.
• W4293864110 cites W2167039110 @default.
• W4293864110 cites W2170527455 @default.
• W4293864110 cites W2296682098 @default.
• W4293864110 cites W2331200198 @default.
• W4293864110 cites W2465995582 @default.
• W4293864110 cites W2480353178 @default.
• W4293864110 cites W2553676377 @default.
• W4293864110 cites W2578308616 @default.
• W4293864110 cites W2619200943 @default.
• W4293864110 cites W2699845746 @default.
• W4293864110 cites W2744478946 @default.
• W4293864110 cites W2767493192 @default.
• W4293864110 cites W2782436909 @default.
• W4293864110 cites W2789259757 @default.
• W4293864110 cites W2796614007 @default.
• W4293864110 cites W2800617744 @default.
• W4293864110 cites W2885725200 @default.
• W4293864110 cites W2914346278 @default.
• W4293864110 cites W2920279714 @default.
• W4293864110 cites W2945174113 @default.
• W4293864110 cites W2950976066 @default.
• W4293864110 cites W2952227234 @default.
• W4293864110 cites W2952995021 @default.
• W4293864110 cites W2953286293 @default.
• W4293864110 cites W2978022936 @default.
• W4293864110 cites W3001465629 @default.
• W4293864110 cites W3025085249 @default.
• W4293864110 cites W3044586123 @default.
• W4293864110 cites W3105012889 @default.
• W4293864110 cites W3106117005 @default.
• W4293864110 cites W3139189563 @default.
• W4293864110 cites W3158834932 @default.
• W4293864110 cites W3193909442 @default.
• W4293864110 cites W3197839114 @default.
• W4293864110 cites W3198714172 @default.

• next