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- W4294018275 abstract "The nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling pathway is an effective mechanism involved in the treatment of hypertension. In our search for potential antihypertensive agents, a series of novel NO-donor derivatives of the 4-chromanone skeleton were designed and synthesized by coupling furoxans or nitrooxy NO-donor moieties. All derivatives showed enhanced nitric oxide releasing capacity and vasodilator activity with EC50 values ranging from 0.0215 μM to 1.46 μM, obviously superior to those of precursor 3. These biological evaluations indicated that all compounds displayed an important vasorelaxant effect, and several compounds (9c, 14b, 14c, 14d) presented good vasodilator activity, with 14c being the best. Furthermore, molecular modeling studies revealed that compound 14c occupied the pocket well with the phosphodiesterase 5 domain in a favorable conformation. In conclusion, we observed that these novel compounds can act as structural templates for the design and subsequent development of new vasodilators and antihypertensive drugs." @default.
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- W4294018275 date "2022-10-27" @default.
- W4294018275 modified "2023-10-14" @default.
- W4294018275 title "Design, synthesis, and biological evaluation of novel <scp>NO‐releasing</scp> 4‐chromanone derivatives as potential vasodilator agents" @default.
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- W4294018275 doi "https://doi.org/10.1111/cbdd.14140" @default.
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