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- W4294026024 abstract "Abstract Background The effect of genetic polymorphisms on fasting blood lipid levels have been widely studied but the effects of these within the context of a high-fat meal challenge remain less characterized. The current study aimed to investigate the association of SNPs in lipoprotein-related genes with blood lipid profiles in healthy adults in the U.S. Methods Subjects ( n = 393) between 18–66 years of age with BMIs ranging from 18.5–45 kg/m 2 were enrolled the cross-sectional Nutritional Phenotyping Study. Among them, 349 subjects (men: 48%; women: 52%) gave consent for genotyping. SNPs in APOA5 , APOB , APOC3 , APOE , and LDLR were assessed. The association between lipid markers and genotypes was tested separately for each SNP with analysis of variance (ANOVA), adjusted for sex, age, and BMI. We also examined two-factor interactions between SNPs and sex, age, or BMI. Results Women carrying the C allele of rs3135506 in APOA5 or men carrying the C allele of rs429358 in APOE had reduced HDL-cholesterol levels during fasting and postprandially. The C allele in APOE was also correlated to increased LDL-C levels. The TT genotype of rs2854116 in APOC3 was associated with elevated total cholesterol. Additive effect of the risk alleles of APOA5 and APOE or APOC3 and APOE was detected. Nevertheless, the tested SNPs had little impact on the postprandial triglyceride responses to the high-fat challenge meal. We found no significant effects of SNPs in APOB (rs1042034) or LDLR (rs2228671) on triglycerides, cholesterol, or free fatty acid levels. Conclusions In healthy adults, fasting and postprandial cholesterol levels are strongly correlated with the tested APOA5 , APOE , and APOC3 genotypes. Sex contributes to the genetic impact of the tested SNPs on lipid profiles. Trial registration ClinicalTrials.gov, NCT02367287. Registered February 20, 2015, https://clinicaltrials.gov/ct2/show/NCT02367287 ." @default.
- W4294026024 created "2022-09-01" @default.
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- W4294026024 date "2022-09-01" @default.
- W4294026024 modified "2023-10-17" @default.
- W4294026024 title "SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults" @default.
- W4294026024 cites W1920171370 @default.
- W4294026024 cites W1969830206 @default.
- W4294026024 cites W1993145512 @default.
- W4294026024 cites W1993718080 @default.
- W4294026024 cites W1995618009 @default.
- W4294026024 cites W2005933615 @default.
- W4294026024 cites W2006862294 @default.
- W4294026024 cites W2012194144 @default.
- W4294026024 cites W2016500417 @default.
- W4294026024 cites W2023466812 @default.
- W4294026024 cites W2025242285 @default.
- W4294026024 cites W2031404119 @default.
- W4294026024 cites W2034968148 @default.
- W4294026024 cites W2036362108 @default.
- W4294026024 cites W2038970022 @default.
- W4294026024 cites W2041917916 @default.
- W4294026024 cites W2050015311 @default.
- W4294026024 cites W2057394745 @default.
- W4294026024 cites W2077760013 @default.
- W4294026024 cites W2094317372 @default.
- W4294026024 cites W2096432979 @default.
- W4294026024 cites W2099126143 @default.
- W4294026024 cites W2099331111 @default.
- W4294026024 cites W2101125172 @default.
- W4294026024 cites W2105688337 @default.
- W4294026024 cites W2114245293 @default.
- W4294026024 cites W2121101037 @default.
- W4294026024 cites W2121525857 @default.
- W4294026024 cites W2124481954 @default.
- W4294026024 cites W2127037606 @default.
- W4294026024 cites W2127958304 @default.
- W4294026024 cites W2133025759 @default.
- W4294026024 cites W2133990668 @default.
- W4294026024 cites W2138841151 @default.
- W4294026024 cites W2139642496 @default.
- W4294026024 cites W2140566574 @default.
- W4294026024 cites W2141545294 @default.
- W4294026024 cites W2142315064 @default.
- W4294026024 cites W2144952623 @default.
- W4294026024 cites W2151580122 @default.
- W4294026024 cites W2151599123 @default.
- W4294026024 cites W2152688545 @default.
- W4294026024 cites W2153104686 @default.
- W4294026024 cites W2153350589 @default.
- W4294026024 cites W2163592337 @default.
- W4294026024 cites W2163710303 @default.
- W4294026024 cites W2164724187 @default.
- W4294026024 cites W2169934414 @default.
- W4294026024 cites W2190211817 @default.
- W4294026024 cites W2210383430 @default.
- W4294026024 cites W2344523856 @default.
- W4294026024 cites W2416854880 @default.
- W4294026024 cites W2435745310 @default.
- W4294026024 cites W2471143596 @default.
- W4294026024 cites W2508635189 @default.
- W4294026024 cites W2527660462 @default.
- W4294026024 cites W2560393860 @default.
- W4294026024 cites W2588919328 @default.
- W4294026024 cites W2652911668 @default.
- W4294026024 cites W2747965843 @default.
- W4294026024 cites W2750769016 @default.
- W4294026024 cites W2765240127 @default.
- W4294026024 cites W2776105884 @default.
- W4294026024 cites W2884718100 @default.
- W4294026024 cites W2899689685 @default.
- W4294026024 cites W2947315865 @default.
- W4294026024 cites W2996027807 @default.
- W4294026024 cites W2996599703 @default.
- W4294026024 cites W3047168153 @default.
- W4294026024 cites W3159559000 @default.
- W4294026024 cites W3186920348 @default.
- W4294026024 cites W4244668309 @default.
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- W4294026024 doi "https://doi.org/10.1186/s40795-022-00592-x" @default.
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- W4294026024 hasPublicationYear "2022" @default.
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