FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294032014> ?p ?o ?g. }

• W4294032014 abstract "Hydrocephalus is a serious condition that affects patients of all ages, resulting from a multitude of causes. While the etiologies of hydrocephalus are numerous, many of the acute and chronic symptoms of the condition are shared. These symptoms include disorientation and pain (headaches), cognitive and developmental changes, vision and sleep disturbances, and gait abnormalities. This collective group of symptoms combined with the effectiveness of CSF diversion as a surgical intervention for many types of the condition suggest that the various etiologies may share common cellular and molecular dysfunctions. The incidence rate of pediatric hydrocephalus is approximately 0.1-0.6% of live births, making it as common as Down syndrome in infants. Diagnosis and treatment of various forms of adult hydrocephalus remain understudied and underreported. Surgical interventions to treat hydrocephalus, though lifesaving, have a high incidence of failure. Previously tested pharmacotherapies for the treatment of hydrocephalus have resulted in net zero or negative outcomes for patients potentially due to the lack of understanding of the cellular and molecular mechanisms that contribute to the development of hydrocephalus. Very few well-validated drug targets have been proposed for therapy; most of these have been within the last 5 years. Within the last 50 years, there have been only incremental improvements in surgical treatments for hydrocephalus, and there has been little progress made towards prevention or cure. This demonstrates the need to develop nonsurgical interventions for the treatment of hydrocephalus regardless of etiology. The development of new treatment paradigms relies heavily on investment in researching the common molecular mechanisms that contribute to all of the forms of hydrocephalus, and requires the concerted support of patient advocacy organizations, government- and private-funded research, biotechnology and pharmaceutical companies, the medical device industry, and the vast network of healthcare professionals." @default.
• W4294032014 created "2022-09-01" @default.
• W4294032014 creator A5011824995 @default.
• W4294032014 creator A5045052186 @default.
• W4294032014 creator A5055883107 @default.
• W4294032014 date "2022-09-01" @default.
• W4294032014 modified "2023-10-13" @default.
• W4294032014 title "Hydrocephalus: historical analysis and considerations for treatment" @default.
• W4294032014 cites W1106124941 @default.
• W4294032014 cites W128800582 @default.
• W4294032014 cites W1514024495 @default.
• W4294032014 cites W1520953497 @default.
• W4294032014 cites W1593887887 @default.
• W4294032014 cites W1669794305 @default.
• W4294032014 cites W1682891130 @default.
• W4294032014 cites W1705993777 @default.
• W4294032014 cites W1710099985 @default.
• W4294032014 cites W1965974931 @default.
• W4294032014 cites W1970941053 @default.
• W4294032014 cites W1973294015 @default.
• W4294032014 cites W1973613551 @default.
• W4294032014 cites W1974659683 @default.
• W4294032014 cites W1975008916 @default.
• W4294032014 cites W1982702233 @default.
• W4294032014 cites W1982719177 @default.
• W4294032014 cites W1991260533 @default.
• W4294032014 cites W1991522247 @default.
• W4294032014 cites W1992209211 @default.
• W4294032014 cites W1995453564 @default.
• W4294032014 cites W2000907119 @default.
• W4294032014 cites W2003860600 @default.
• W4294032014 cites W2009611399 @default.
• W4294032014 cites W2010490848 @default.
• W4294032014 cites W2011557706 @default.
• W4294032014 cites W2015115312 @default.
• W4294032014 cites W2016116736 @default.
• W4294032014 cites W2022311164 @default.
• W4294032014 cites W2026481572 @default.
• W4294032014 cites W2027596014 @default.
• W4294032014 cites W2036578652 @default.
• W4294032014 cites W2039146327 @default.
• W4294032014 cites W2042788569 @default.
• W4294032014 cites W2053359531 @default.
• W4294032014 cites W2053895560 @default.
• W4294032014 cites W2066230087 @default.
• W4294032014 cites W2068539824 @default.
• W4294032014 cites W2068838710 @default.
• W4294032014 cites W2080854317 @default.
• W4294032014 cites W2083648566 @default.
• W4294032014 cites W2088314252 @default.
• W4294032014 cites W2091048651 @default.
• W4294032014 cites W2092587768 @default.
• W4294032014 cites W2095094278 @default.
• W4294032014 cites W2096525076 @default.
• W4294032014 cites W2106702560 @default.
• W4294032014 cites W2115145148 @default.
• W4294032014 cites W2131774453 @default.
• W4294032014 cites W2132597772 @default.
• W4294032014 cites W2150802909 @default.
• W4294032014 cites W2151201474 @default.
• W4294032014 cites W2157256907 @default.
• W4294032014 cites W2160409715 @default.
• W4294032014 cites W2160939771 @default.
• W4294032014 cites W2167183660 @default.
• W4294032014 cites W2170435537 @default.
• W4294032014 cites W2185677488 @default.
• W4294032014 cites W2230911342 @default.
• W4294032014 cites W2263256000 @default.
• W4294032014 cites W2286581550 @default.
• W4294032014 cites W2336530667 @default.
• W4294032014 cites W2344367297 @default.
• W4294032014 cites W2409917264 @default.
• W4294032014 cites W2512214837 @default.
• W4294032014 cites W2522422641 @default.
• W4294032014 cites W2546554233 @default.
• W4294032014 cites W2599675750 @default.
• W4294032014 cites W2618444850 @default.
• W4294032014 cites W2735906238 @default.
• W4294032014 cites W2789376055 @default.
• W4294032014 cites W2805557898 @default.
• W4294032014 cites W2807474935 @default.
• W4294032014 cites W2820211840 @default.
• W4294032014 cites W2884506029 @default.
• W4294032014 cites W2888109284 @default.
• W4294032014 cites W2893025902 @default.
• W4294032014 cites W2898255378 @default.
• W4294032014 cites W2900579509 @default.
• W4294032014 cites W2901033224 @default.
• W4294032014 cites W2901166225 @default.
• W4294032014 cites W2908608189 @default.
• W4294032014 cites W2913511167 @default.
• W4294032014 cites W2938203832 @default.
• W4294032014 cites W2946268465 @default.
• W4294032014 cites W2977281925 @default.
• W4294032014 cites W2980037152 @default.
• W4294032014 cites W3000093244 @default.
• W4294032014 cites W3005603509 @default.
• W4294032014 cites W3006202991 @default.
• W4294032014 cites W3007240445 @default.
• W4294032014 cites W3010263513 @default.

• next